ID N8V707_9GAMM Unreviewed; 868 AA.
AC N8V707;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=F970_01596 {ECO:0000313|EMBL:ENU95661.1};
OS Acinetobacter sp. CIP 102082.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=1144663 {ECO:0000313|EMBL:ENU95661.1, ECO:0000313|Proteomes:UP000018448};
RN [1] {ECO:0000313|EMBL:ENU95661.1, ECO:0000313|Proteomes:UP000018448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIP 102082 {ECO:0000313|EMBL:ENU95661.1,
RC ECO:0000313|Proteomes:UP000018448};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cerqueira G., Feldgarden M., Courvalin P., Perichon B.,
RA Grillot-Courvalin C., Clermont D., Rocha E., Yoon E.-J., Nemec A.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Acinetobacter sp. CIP 102082.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENU95661.1}.
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DR EMBL; APPD01000049; ENU95661.1; -; Genomic_DNA.
DR AlphaFoldDB; N8V707; -.
DR PATRIC; fig|1144663.3.peg.1574; -.
DR HOGENOM; CLU_009503_0_0_6; -.
DR Proteomes; UP000018448; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR041635; Type_ISP_LLaBIII_C.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR Pfam; PF18135; Type_ISP_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 383..590
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 701..859
FT /note="Type ISP restriction-modification enzyme LLaBIII C-
FT terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF18135"
SQ SEQUENCE 868 AA; 99296 MW; 201025B545E3074B CRC64;
MSHFISTYID RINHRYRLGN ATEHTFRGDL AQLIESIVPD ITATNEPKRQ SCGAPDYILT
KKNIPIGFIE AKDIGDKDLD GLKKTGNKEQ FDRYKASLNN LIFTDYLNFH IYQDGVFITK
IAIAEVTGNH IRALPENFTV FENLIKNFCT HIGQTIKSPK KLAEMMAAKA RLLSDVIEKA
LTSDEDSFED STLKDQKQAF KQILIHDITP KGFADVYAQT IAYGMFAARL HDPTLPTFSR
QEAAELIPKT NPFLRKLFGY IAGPDIDDRI KWIVDSLVDV FLHCNVHEIL KNYGRSTKME
DPIIHFYETF LSEYDPKLRK ARGVWYTPAP VVNFIVRAVD DILKTEFGLA QGLADTSKTT
IEVEATGTAI TKGKAKGKRI TETKEVHKVQ ILDPATGTGT FLAEVVKHIH QKFAGQQGIW
SNYVESHLLP RLNGFELLMA SYAMAHLQLD LLLTDTGYKP KQAQRLRVYL TNSLEESHPD
TGTLFANWLS SEANEANHIK RDTPVMCVIG NPPYSVSSSN KSDWIQSLIA DYKKNLNERK
INLDDDYIKF IRYGQHFIDK NGEGILAYIS NNSFIDGITH RQMRHELLKS FDKIYIIDLH
GNSKKRETAP DGGIDQNVFD IMQGVSINLF VKTGNKKKDE LGKVFHYDLY GKREQKYDFL
KENDLSTIKL QKIPYDFQNY FFVPKDFAND EKYNTGFKID ELFKYSNSGL QTKNDSLTIH
FSQIGVENVL YDLKTLNSLE LRQKYNIQKD GRDWTIDLAK KDITESKGVF FEIQYKPFDF
RKSYYTGNSK GFIAYPRKEL TDHILKEDNL ALATMRQIAG TKQTCIVMLT KAVMTDRAMY
STNGTPYLFP LYLYQNQQLQ VDKSTSRA
//