ID N9GA47_ACIHA Unreviewed; 446 AA.
AC N9GA47;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=HMA domain-containing protein {ECO:0000259|PROSITE:PS50846};
GN ORFNames=F927_02956 {ECO:0000313|EMBL:ENW16385.1};
OS Acinetobacter haemolyticus CIP 64.3 = MTCC 9819.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=1217659 {ECO:0000313|EMBL:ENW16385.1, ECO:0000313|Proteomes:UP000017667};
RN [1] {ECO:0000313|EMBL:ENW16385.1, ECO:0000313|Proteomes:UP000017667}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIP 64.3 {ECO:0000313|EMBL:ENW16385.1,
RC ECO:0000313|Proteomes:UP000017667};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cerqueira G., Feldgarden M., Courvalin P., Perichon B.,
RA Grillot-Courvalin C., Clermont D., Rocha E., Yoon E.-J., Nemec A.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Acinetobacter haemolyticus CIP 64.3.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENW16385.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; APQQ01000030; ENW16385.1; -; Genomic_DNA.
DR RefSeq; WP_005084002.1; NZ_KB849803.1.
DR AlphaFoldDB; N9GA47; -.
DR PATRIC; fig|1217659.3.peg.2905; -.
DR HOGENOM; CLU_679027_0_0_6; -.
DR Proteomes; UP000017667; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.100; -; 1.
DR Gene3D; 1.20.1510.10; Cation efflux protein transmembrane domain; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR PANTHER; PTHR11562; CATION EFFLUX PROTEIN/ ZINC TRANSPORTER; 1.
DR PANTHER; PTHR11562:SF17; LD05335P; 1.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF161111; Cation efflux protein transmembrane domain-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 2.
DR PROSITE; PS50846; HMA_2; 1.
PE 4: Predicted;
KW Ion transport {ECO:0000256|ARBA:ARBA00022906};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022906};
KW Zinc {ECO:0000256|ARBA:ARBA00022906};
KW Zinc transport {ECO:0000256|ARBA:ARBA00022906}.
FT TRANSMEM 274..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 185..248
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 446 AA; 47819 MW; 838634E37AEDFA58 CRC64;
MGTSMSGCGC NKESSCEDTK QNQNESEANS GNSKDLTTEE SKSSCCGNEE SKSSCCGNEE
VPQQSKPDEK DSCASTQLCS TQSNSCCGPN SISSPETVND NEGVATFISD YNIPKMDCSA
EEQMVRMTLS SLLNVKRLVF DLPNRNLKVM HNGESNEITA KLEALGFGAK LNKTEAYVNK
EHAKEISTFL IPKMDCSAEE QMVRMALSPV NEVKGLTFDL PNRKLKVFHN DGLNEITSKL
EALGFGAKLE STAASVGEMP EKADTSEQAK VLKILLAINA ALFVIEFISG LIAASTGLIA
DSLDMFADAA VYGIALYAVG KTAKYQVKAA HFAGWIQLFL AITVIVDVIR RFILGSEPES
LLMIVIGFFA LIANVACLYL ISGHKDGGAH MKASWIFSAN DVIVNLGVII AGFLVALTGS
AYPDLIIGII VSLFVLNGAR KILALK
//