ID N9N071_9GAMM Unreviewed; 435 AA.
AC N9N071;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=fumarylacetoacetase {ECO:0000256|ARBA:ARBA00012094};
DE EC=3.7.1.2 {ECO:0000256|ARBA:ARBA00012094};
GN ORFNames=F903_02031 {ECO:0000313|EMBL:ENW96261.1};
OS Acinetobacter sp. NIPH 298.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=1217692 {ECO:0000313|EMBL:ENW96261.1, ECO:0000313|Proteomes:UP000018428};
RN [1] {ECO:0000313|EMBL:ENW96261.1, ECO:0000313|Proteomes:UP000018428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIPH 298 {ECO:0000313|EMBL:ENW96261.1,
RC ECO:0000313|Proteomes:UP000018428};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cerqueira G., Feldgarden M., Courvalin P., Perichon B.,
RA Grillot-Courvalin C., Clermont D., Rocha E., Yoon E.-J., Nemec A.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Acinetobacter sp. NIPH 298.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC acetoacetate and fumarate from L-phenylalanine: step 6/6.
CC {ECO:0000256|ARBA:ARBA00004782}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENW96261.1}.
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DR EMBL; APRM01000007; ENW96261.1; -; Genomic_DNA.
DR RefSeq; WP_005196754.1; NZ_KB850055.1.
DR AlphaFoldDB; N9N071; -.
DR STRING; 1217692.F903_02031; -.
DR PATRIC; fig|1217692.3.peg.1997; -.
DR HOGENOM; CLU_026207_2_0_6; -.
DR OrthoDB; 3766879at2; -.
DR UniPathway; UPA00139; UER00341.
DR Proteomes; UP000018428; Unassembled WGS sequence.
DR GO; GO:0004334; F:fumarylacetoacetase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.30.30.230; Fumarylacetoacetase, N-terminal domain; 1.
DR Gene3D; 3.90.850.10; Fumarylacetoacetase-like, C-terminal domain; 1.
DR InterPro; IPR005959; Fumarylacetoacetase.
DR InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR InterPro; IPR015377; Fumarylacetoacetase_N.
DR InterPro; IPR036462; Fumarylacetoacetase_N_sf.
DR NCBIfam; TIGR01266; fum_ac_acetase; 1.
DR PANTHER; PTHR43069; FUMARYLACETOACETASE; 1.
DR PANTHER; PTHR43069:SF2; FUMARYLACETOACETASE; 1.
DR Pfam; PF01557; FAA_hydrolase; 1.
DR Pfam; PF09298; FAA_hydrolase_N; 1.
DR SUPFAM; SSF56529; FAH; 1.
DR SUPFAM; SSF63433; Fumarylacetoacetate hydrolase, FAH, N-terminal domain; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phenylalanine catabolism {ECO:0000256|ARBA:ARBA00023232};
KW Tyrosine catabolism {ECO:0000256|ARBA:ARBA00022878}.
FT DOMAIN 20..122
FT /note="Fumarylacetoacetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF09298"
FT DOMAIN 129..416
FT /note="Fumarylacetoacetase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01557"
SQ SEQUENCE 435 AA; 48661 MW; 42CC92E0D6200F63 CRC64;
MTQHLTSFLE IDPQSDFTMH NLPYGIFSEI AQANKRVGVA IGDWVIDLAV LETHGLLQLD
GNQNYFNQPT LNTFIESGKQ NWQKVRQTLQ NLLSIDNPTL RDNAELRKLV LLQQNTVTLH
LPIHVPGYTD FYSSKEHATN VGTMFRDPKN ALLPNWSELP VGYNGRASSV IVSGTDIVRP
SGQIKLPNSE RPVFSATRKL DFELETAFIV GKATKLGQPI SIEDASDHIF GMVLLNDWSA
RDIQQWEYVP LGPFNAKTFA SAISPWVVTM EALEPFKVKG PTQQPQPLGY LQENIANSYD
IHLSVEVQTP QSQKSDVICQ TNFKYMYWSM AQQLTHHTIA GCNVQVGDLM GSGTISGPTE
DSYGSLLELT WNTTKPLILS NGETRGFLED GDRVVMKGYC EKDGIRVGFG QVENTILAAH
KFEFNQTEEE SYETV
//