ID N9Q5Z7_9GAMM Unreviewed; 434 AA.
AC N9Q5Z7;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=fumarylacetoacetase {ECO:0000256|ARBA:ARBA00012094};
DE EC=3.7.1.2 {ECO:0000256|ARBA:ARBA00012094};
GN ORFNames=F887_01585 {ECO:0000313|EMBL:ENX41189.1};
OS Acinetobacter sp. NIPH 2100.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=1217708 {ECO:0000313|EMBL:ENX41189.1, ECO:0000313|Proteomes:UP000013196};
RN [1] {ECO:0000313|EMBL:ENX41189.1, ECO:0000313|Proteomes:UP000013196}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIPH 2100 {ECO:0000313|EMBL:ENX41189.1,
RC ECO:0000313|Proteomes:UP000013196};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cerqueira G., Feldgarden M., Courvalin P., Perichon B.,
RA Grillot-Courvalin C., Clermont D., Rocha E., Yoon E.-J., Nemec A.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Acinetobacter sp. NIPH 2100.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC acetoacetate and fumarate from L-phenylalanine: step 6/6.
CC {ECO:0000256|ARBA:ARBA00004782}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENX41189.1}.
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DR EMBL; APSB01000010; ENX41189.1; -; Genomic_DNA.
DR RefSeq; WP_005293583.1; NZ_KB850224.1.
DR AlphaFoldDB; N9Q5Z7; -.
DR STRING; 1217708.F887_01585; -.
DR PATRIC; fig|1217708.3.peg.1532; -.
DR eggNOG; COG0179; Bacteria.
DR HOGENOM; CLU_026207_2_0_6; -.
DR OrthoDB; 3766879at2; -.
DR UniPathway; UPA00139; UER00341.
DR Proteomes; UP000013196; Unassembled WGS sequence.
DR GO; GO:0004334; F:fumarylacetoacetase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.30.30.230; Fumarylacetoacetase, N-terminal domain; 1.
DR Gene3D; 3.90.850.10; Fumarylacetoacetase-like, C-terminal domain; 1.
DR InterPro; IPR005959; Fumarylacetoacetase.
DR InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR InterPro; IPR015377; Fumarylacetoacetase_N.
DR InterPro; IPR036462; Fumarylacetoacetase_N_sf.
DR NCBIfam; TIGR01266; fum_ac_acetase; 1.
DR PANTHER; PTHR43069; FUMARYLACETOACETASE; 1.
DR PANTHER; PTHR43069:SF2; FUMARYLACETOACETASE; 1.
DR Pfam; PF01557; FAA_hydrolase; 1.
DR Pfam; PF09298; FAA_hydrolase_N; 1.
DR SUPFAM; SSF56529; FAH; 1.
DR SUPFAM; SSF63433; Fumarylacetoacetate hydrolase, FAH, N-terminal domain; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phenylalanine catabolism {ECO:0000256|ARBA:ARBA00023232};
KW Tyrosine catabolism {ECO:0000256|ARBA:ARBA00022878}.
FT DOMAIN 20..121
FT /note="Fumarylacetoacetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF09298"
FT DOMAIN 128..415
FT /note="Fumarylacetoacetase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01557"
SQ SEQUENCE 434 AA; 48624 MW; 1C8FD64B8470ECDE CRC64;
MAHHLTSFLE IDAQSDFTIH NLPYGIFSET TQGDKRVGVA IGDWVLDLAA LEQKGLLQLT
TSNCFNQPTL NKFIETGKQN WHTVRNTLQS LLSTENPTLR DHADLRQQVL FKQQDVVLHL
PIQVPGYTDF YSSKEHATNV GTMFRDPKNA LLPNWSELPV GYNGRASSVI VSGKDIVRPS
GQIKLPNEER PVFSATRKLD FELETAFVVG KATELGEPIA IENAWNHIFG MVLLNDWSAR
DIQQWEYVPL GPFNAKTFAS AISPWVVTME ALEPFRVTGP EQQPQPLGYL QENTANSYDI
HLSVEVQTPQ SPQADVICQT NFKYMYWSMA QQLTHHTIAG CNVQVGDLMG SGTISGSTED
SYGSLLELTW NTTKPLHLSN GETRGFLEDG DRVVMKGYCE KDGIRVGFGE VANTILPARH
FSFNEQKDER YETV
//
