ID   NAHR_PSEPU              Reviewed;         300 AA.
AC   P10183;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 2.
DT   03-MAY-2023, entry version 94.
DE   RecName: Full=HTH-type transcriptional activator NahR;
GN   Name=nahR;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OG   Plasmid NAH7.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2703465; DOI=10.1128/jb.171.4.1952-1959.1989;
RA   Schell M.A., Sukordhaman M.;
RT   "Evidence that the transcription activator encoded by the Pseudomonas
RT   putida nahR gene is evolutionarily related to the transcription activators
RT   encoded by the Rhizobium nodD genes.";
RL   J. Bacteriol. 171:1952-1959(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2848005; DOI=10.1128/jb.170.12.5409-5415.1988;
RA   You I.-S., Ghosal D., Gunsalus I.C.;
RT   "Nucleotide sequence of plasmid NAH7 gene nahR and DNA binding of the nahR
RT   product.";
RL   J. Bacteriol. 170:5409-5415(1988).
CC   -!- FUNCTION: Regulates the expression of the naphthalene (nahA-F) and
CC       salicylate (nahG-M) metabolism genes.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA98184.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; J04233; AAA25445.1; -; Genomic_DNA.
DR   EMBL; M22723; AAA98184.1; ALT_FRAME; Genomic_DNA.
DR   PIR; A31382; A31382.
DR   PIR; A32837; A32837.
DR   AlphaFoldDB; P10183; -.
DR   SMR; P10183; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd08459; PBP2_DntR_NahR_LinR_like; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30118; HTH-TYPE TRANSCRIPTIONAL REGULATOR LEUO-RELATED; 1.
DR   PANTHER; PTHR30118:SF15; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Aromatic hydrocarbons catabolism; Cytoplasm; DNA-binding;
KW   Plasmid; Transcription; Transcription regulation.
FT   CHAIN           1..300
FT                   /note="HTH-type transcriptional activator NahR"
FT                   /id="PRO_0000105688"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   300 AA;  33932 MW;  853E0D2A38F62FF0 CRC64;
     MELRDLDLNL LVVFNQLLVD RRVSITAENL GLTQPAVSNA LKRLRTSLQD PLFVRTHQGM
     EPTPYAAHLA EPVTSAMHAL RNALQHHESF DPLTSERTFT LAMTDIGEIY FMPRLMDVLA
     HQAPNCVIST VRDSSMSLMQ ALQNGTVDLA VGLLPNLQTG FFQRRLLQNH YVCLCRKDHP
     VTREPLTLER FCSYGHVRVI AAGTGHGEVD TYMTRVGIRR DIRLEVPHFA AVGHILQRTD
     LLATVPIRLA DCCVEPFGLS ALPHPVVLPE IAINMFWHAK YHKDLANIWL RQLMFDLFTD
//