ID NTPI_ENTHA Reviewed; 664 AA.
AC P43439; I6TB87;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2013, sequence version 2.
DT 24-JAN-2024, entry version 110.
DE RecName: Full=V-type sodium ATPase subunit I;
DE AltName: Full=Na(+)-translocating ATPase subunit I;
DE AltName: Full=V-type sodium pump subunit I;
GN Name=ntpI; Synonyms=ntpM; OrderedLocusNames=EHR_08235;
OS Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 /
OS NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=768486;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459
RC / NCDO 1258 / NCTC 12367 / WDCM 00089 / R;
RX PubMed=8157629; DOI=10.1016/s0021-9258(19)78088-0;
RA Takase K., Kakinuma S., Yamato I., Konishi K., Igarashi K., Kakinuma Y.;
RT "Sequencing and characterization of the ntp gene cluster for vacuolar-type
RT Na(+)-translocating ATPase of Enterococcus hirae.";
RL J. Biol. Chem. 269:11037-11044(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459
RC / NCDO 1258 / NCTC 12367 / WDCM 00089 / R;
RX PubMed=8144530; DOI=10.1016/s0021-9258(17)36902-8;
RA Solioz M., Davies K.;
RT "Operon of vacuolar-type Na(+)-ATPase of Enterococcus hirae.";
RL J. Biol. Chem. 269:9453-9459(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459
RC / NCDO 1258 / NCTC 12367 / WDCM 00089 / R;
RX PubMed=22933757; DOI=10.1128/jb.01075-12;
RA Gaechter T., Wunderlin C., Schmidheini T., Solioz M.;
RT "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790,
RT a model organism for the study of ion transport, bioenergetics, and copper
RT homeostasis.";
RL J. Bacteriol. 194:5126-5127(2012).
CC -!- FUNCTION: Involved in ATP-driven sodium extrusion.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000305}.
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DR EMBL; D17462; BAA04270.1; -; Genomic_DNA.
DR EMBL; X76913; CAA54236.1; -; Genomic_DNA.
DR EMBL; CP003504; AFM70574.1; -; Genomic_DNA.
DR PIR; B53610; B53610.
DR RefSeq; WP_010738016.1; NZ_KB946231.1.
DR AlphaFoldDB; P43439; -.
DR SMR; P43439; -.
DR TCDB; 3.A.2.2.2; the h+- or na+-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.
DR KEGG; ehr:EHR_08235; -.
DR eggNOG; COG1269; Bacteria.
DR HOGENOM; CLU_025558_1_0_9; -.
DR OrthoDB; 9803814at2; -.
DR BioCyc; MetaCyc:MONOMER-14154; -.
DR Proteomes; UP000002895; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
PE 3: Inferred from homology;
KW Cell membrane; Ion transport; Membrane; Reference proteome; Sodium;
KW Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..664
FT /note="V-type sodium ATPase subunit I"
FT /id="PRO_0000119244"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 496..516
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 522..542
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 574..594
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 601..621
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 501
FT /note="G -> W (in Ref. 1; BAA04270)"
FT /evidence="ECO:0000305"
FT CONFLICT 515
FT /note="I -> T (in Ref. 1; BAA04270)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 664 AA; 75504 MW; A914002F489C70B6 CRC64;
MAVTKMEKVT LISDKKNREI LLQAVQGLHA VEIRDLFQES ENNQWVETFF PEPEMIDKDK
ELAKLSYKLT DIRTAIQFIE HHGEKSQKKQ HLKRRELSLD TLEKNYSEEA FSKKLEEVLL
LKEQWEQLVD ERQQLEDQEN WLLNWQNLDL APKAFDSQMT KLVIGTVNAK NAESFKAEVA
EINEAYLEEI NSSPTTTYFA YIVLRADESR MEEIASRYGF VKEDYLYEGT PQQQLVAAKQ
SLQEIKDQQK KLSSAIGACS GYIKDFEWTE EIFLARSERE AIKDRIIHTP YLILIQGWVD
HEEKQELIHM LQNILASEEV YLTFDEPTDN EIAEEVPTKL KNHPIVAPFE MLTEMYSLPK
YEEVDPTPWM MPFYLVFFGM MVADIGYGLL MFLGAFLLQK LVVLPRGMQR FAKFFEILAI
PSIIWGFIYS SFFGAALPKE IFGIHLPFPI LSTTDDVNTI LILSVIFGLI QILVGLFIAA
KEHIKRKAYV DAVNDGFAWQ GILLGIILIL LGTMILKNNA FVYLGGALAV LSAVCILIIP
VFQSSSKAKG IAKGAYNLYG LTGYIGDLVS YTRLMALGIS GGSIAAAFNM LVAFMPPAAR
FSVGILLIIV LQALNMFLTL LSAYVHGARL QYVEFFGKFY TGGGRSFKPL KTVEKYVNIN
HKKK
//
