ID O03849_SOLLC Unreviewed; 456 AA.
AC O03849;
DT 01-JUL-1997, integrated into UniProtKB/TrEMBL.
DT 01-JUL-1997, sequence version 1.
DT 22-FEB-2023, entry version 94.
DE SubName: Full=Branched chain alpha-keto acid dehydrogenase E1-alpha subunit {ECO:0000313|EMBL:CAB08111.1};
DE EC=1.2.4.4 {ECO:0000313|EMBL:CAB08111.1};
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081 {ECO:0000313|EMBL:CAB08111.1};
RN [1] {ECO:0000313|EMBL:CAB08111.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Roots {ECO:0000313|EMBL:CAB08111.1};
RA Giritch A., Baumlein H.;
RT "A molecular cloning and characterization of cDNA coding for the branched
RT chain alpha-keto acid dehydrogenase E1-alpha subunit of tomato.";
RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; Z94180; CAB08111.1; -; mRNA.
DR PIR; T06589; T06589.
DR RefSeq; NP_001234066.2; NM_001247137.2.
DR AlphaFoldDB; O03849; -.
DR GeneID; 778303; -.
DR KEGG; sly:778303; -.
DR OrthoDB; 952at2759; -.
DR ExpressionAtlas; O03849; baseline and differential.
DR GO; GO:0003863; F:3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity; IEA:UniProtKB-EC.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR43380:SF12; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA 1, MITOCHONDRIAL-LIKE; 1.
DR PANTHER; PTHR43380; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 2: Evidence at transcript level;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:CAB08111.1}.
FT DOMAIN 119..415
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 456 AA; 51324 MW; 965F479FFBDC536C CRC64;
MATWFLRRLN NHGVMQKLSM AFSGKSTTAI GRRYFVSMEV GQKLDPYSCD DDYRENIDHQ
NQDLDFPGGK IPLTSQMKFI SEASEKRLPC YRVLNDDGSL ISNSIHDQLG EEVAVNMYSA
MVTLKTMDTY LYEAQRQGRI SFYMTTFGEE AINIASAAAL SPHDFVLPQY REAGVLLWRG
FTVQECTNQC FGNKDDKGKG RQMPVHYGSN KHNVITISSP LATQISQAAG VAYSLKMDKT
GACAVAYTGE GATSEGDFHA GLNFAAVLEA PVIFLCRNNG WAISTPVHEQ FRSDGIVSKG
LGYGIRSIRV DGNDVIAVYN AVRAARTMAI SEERPILVEA MTYRVGHHST SDDSTKYRPT
NEIEYWKTAR CPINLFRKHI QRNGWWSDVQ ESELYTHVKN QVLEAIKTAE GMEKPALTEL
FSDVYEKMTP NLQEQERCIR DAIHKYPKDY PTDFQA
//
