ID O11979_9SECO Unreviewed; 3443 AA.
AC O11979;
DT 01-JUL-1997, integrated into UniProtKB/TrEMBL.
DT 01-JUL-1997, sequence version 1.
DT 27-MAR-2024, entry version 136.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
OS Maize chlorotic dwarf virus.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Secoviridae; Waikavirus; Waikavirus zeae.
OX NCBI_TaxID=51354 {ECO:0000313|EMBL:AAB58882.1};
RN [1] {ECO:0000313|EMBL:AAB58882.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tennessee {ECO:0000313|EMBL:AAB58882.1};
RX PubMed=9152437;
RA Reddick B.B., Habera L.F., Law M.D.;
RT "Nucleotide sequence and taxonomy of maize chlorotic dwarf virus within the
RT family Sequiviridae.";
RL J. Gen. Virol. 78:1165-1174(1997).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U67839; AAB58882.1; -; mRNA.
DR RefSeq; NP_619716.1; NC_003626.1.
DR MEROPS; C03.024; -.
DR GeneID; 940227; -.
DR KEGG; vg:940227; -.
DR Proteomes; UP000207690; Genome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23169; ps-ssRNAv-Picornavirales; 1.
DR CDD; cd00205; rhv_like; 1.
DR Gene3D; 1.20.960.20; -; 1.
DR Gene3D; 2.60.120.20; -; 3.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR044067; PCV_3C_PRO.
DR InterPro; IPR024387; Pept_C3G_Picornavir.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001676; Picornavirus_capsid.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR033703; Rhv-like.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR InterPro; IPR029053; Viral_coat.
DR InterPro; IPR024379; Waikavirus_capsid-1.
DR Pfam; PF12381; Peptidase_C3G; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00073; Rhv; 1.
DR Pfam; PF00910; RNA_helicase; 1.
DR Pfam; PF12264; Waikav_capsid_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51874; PCV_3C_PRO; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Covalent protein-RNA linkage {ECO:0000256|ARBA:ARBA00022520};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Virion {ECO:0000256|ARBA:ARBA00022561}.
FT TRANSMEM 1502..1520
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1532..1554
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1597..1617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2343..2364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1748..1916
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 2609..2823
FT /note="Peptidase C3"
FT /evidence="ECO:0000259|PROSITE:PS51874"
FT DOMAIN 3123..3254
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT REGION 658..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1350..1376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..679
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1358..1375
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3443 AA; 387662 MW; AF8A88897A7E136E CRC64;
MMSCEQSKNN NNQQSTALEN SEIRYPGGYY IPLGDGGIRV PVEAIYRPGE PQNWVPICGN
DFHLSQDDPC SECDAIEGSS ERAAIAISDS YVASDPHFTV DARSLSRRDH TCTHRGCFSI
CSSYRFCSFC LFLFNLDKFQ KNTKYFHSKR SLSRLVHCSA EQLISNAILF SSNRIIDAEV
VADNRVSCEY AKLLLSNARV GVQVTPPACD WVVCNNVEHL FECFGISDAQ RGHITGFNDE
NAYWNASCAK CGACCQGANA RSAIPIVLLL KFITIRKEQD IWLASHMHHD NDFVEINSIT
AQIIAKINNI PNVDEPAVGY MGSKLENWIS YRDTDFTEED WTLKHPCSGP LESEECDHDF
IIRNQYGFEL YLNHAMLLNF AALCLYHGRL YNSDKSVGIL VTFGGMIGVN IACNEAFMEF
HKRFYSGTLR ISPMNMYLRR ERCQAQSDFN DEEFQRLMAE EGDAEIQSVS NWVSEYLEIE
DVIDIVDEAE SKKTRGLGLN QVLGGLLKGV SHCVDSLHKV FDWPIDLAID AAKGTADWLE
GNKSSVDDSK ICAGCPEIQK DMQDFQKETK MGIEILRDSI KKLSEGIDKI TRMNQTNFER
IVDRIRPIES KLKELEKIKP DAGGSKDSEA MRQLVQAIKD IKLIKQAMME LNDRIKDLED
SKQHQEDSKP DDDTAGEQKP IPKINKIRVK AKRVEKQSGT NIVNNEIEQA FQDEEKRTVD
PNISDMYNAI KSEYLVKSFS WKVSDGQDKV LSNINIPEDL WNTNSRLNDI MSYFQYYKAT
GLTFRISTTC IPMHGGTLFA AWDACGCATR QGIATAVQLT GLPGIMIEAH SSSLTTFSVE
DPLTQSTVCL SGSEHSFGRI GILKICCLNV LNAPQAATQS VSVNVWVKFD GVKFHFYSLK
KQPVVSQMLV DKLTNLGEMG CVVATGTWST TSSLNLLQLN VHPTACFISD GLVTQTPLSV
IAHAFARWRG SLKFTITFGA SMFTRGRVLV AAIPVAKRKE TLTIEEISGY HNVMCLLNGE
RTSFELEVPY HSVGEDSYVC RDALFDVSSY AQNFMITRLH MVVIDTLVMS SNASNTISYC
VMMGPGKDLE LRYLNGVHAQ RNVRELKAQV SLGFSLQSGR NIGVGFSDLL KRWAHLLTLH
FDENNEKSEE KVGSYIVTVA PSYRAFPQHN TLLSWFSQLF VQWQGSLCYR LHVDSQERRY
GGYLRIWHDP NGSLDEGVEF AMSTNLEPPP GAFVKYWNYN EQSEFEFVVP YTARTPRLFV
PKAMIPTDSK SWILNYNGTL NFDYRGVDDF NVTVDISAGD NFEFSVRTVA PKAGKVNESF
TKLSYSNELV DIKKPLTAAG RLKGPFNLNT LKTAVPKETP KESSDDKDKS NQKRKGAMDS
LLNAVAQMET INSDANGCFS LGGLKSTAKM LDSRKTCEKF ADIMDFTHDT LGVKDGPAAQ
RLAAAVAQIA PIIESVSRTT ESVESKLTCL DKYKDGILGI LQSLCKETIP GLAIVDFKKG
KYMWATLLTL IAGAALFWAC KSQKSFLKRF SVVVMIIWSP FLAGKVWSLG QWIVQKWCHL
WPKSDSCRQH SLAGLFESAK TKVRGFPDWF RSGGMNIVTQ VCSVLLTIVS LITLGTIPSA
KKSKSLADRF IEFGNMNRAA TSIAAGYKSI SELCSKFTHF VATHFLGATV DDNVFKDLVT
FNVKDWVEQV KVASLEENKF KSFGSPEQLT RVRHMYDKSL EITNKLLDRN KVPVAMLPVI
RDTCKKCEEL LNDSYSYKGM KTPRIDPFYI CLTGPPGVGK STVASIIIND LLDYMGEPKT
DRIYTRCCAD SYWSNYHHEP VIIYDDLGAI SKVASLSDYA EIMGIKSNRP YSLPMAAVEE
KGRHCLSKYL VACTNLTHLD DTGDVKTKEA YYRRINLPVT VERDLAMPMS PEDPASGLLF
TIGDIHENGR NVSVVESRLL NGRVPFRAGD LRNMSYNYFM EFVRIYATIY MENQQQLVAK
LSGDDYESSS SSFPENEELE FDFLAQAHNG VYLTIEEVVA KFESMKFSGK QLNAEIEKFE
RIGVDGWRTN KALSFNDLVK RFCGCCLGDD CNFDFHYRTL FKVLIENKQI PAYKCMVLHK
VNPDRMKTQI KMVNGYTLET MFKTLNPLTI FLYLVFVLKC GISADNVCLS YQLFAMNDAE
QVEFEIEDSL RLDEQVQIGQ YSCYVWPSVG KFYPEILAKR GCIAVNDGTT FYIFVSSSQI
DKIHPEAAWS DMLQGVGRRG VDILSIAGPT KTKFLIKHVE SCYETLKSPE DWKAKCKEYY
ESISLYEYIL LLMAVGSRAG IETQRMSKYQ ARKNKIRMPE VLEKYIEVEK ATIGKLSKPA
KTCLAIGAGV AIFGVLAGLG VGLYKLITHF SKTDSEDNDI EIDDLVPEMS GAHASDENVT
TYAVRRQVPK VRLAKQFKVR SSPSPSDNEQ PKVDILVPEM TGCHASDEHL TKHFTKRRVT
MKRVGAVKES HIVTYDENTP HVRLIRNLRR TRLARAIKQM AQLGELPDTL SEIQVWQQYV
VDKGIRPAEH TTDFRLFSAI ADQEQEDPEE INMASGETMK FDENKYNEIV QVVKGISPTK
SDIVTMTTKG AHHTAIKQVR IGYKSLDKDP NMVSILSNQL TKISCVILNV TPGRTAYLNV
MRLCGTFVVC PAHYLEALEE DDTIYFISFS VCIKLRFQPD RVTLVNTHQD LVVWDLGNSV
PPAIDVLSMI PTVADWDKFQ DGPGAFGVTK YNARYPTNYI NTLDMIERIR ADTQNPTGIY
KMLNSDHTIT TGLRYQMYSL EGFCGGLILR ACTRMVRKIV GLHVAASANH AMGYAECLVQ
EDLKHAINKL SPDARSLIIG HLNPKVETAT KQCGIVRSLG SLGCHGKVTS EDVAMTATKT
TIRKSRIYGL VGDIKTEPSI LHAHDPRLPE DQIGKWDPVF EAALKYGTRI EPFPIEEILE
VEDHLSIILK GMDNTLKKRN VNNLEVGING IDQSDYWLQI ETNTSPGWPY TKRKPKGAEG
KKWLFKEVGN YPSGKPILEM EDSGLIESYN KMLRDAKQGV APIVVTVECP KDERRKLSKI
YEQPATRTFT ILPPEINILF RQYFGDFAAM IMTNRSKLFC QVGINPENME WSDLMHEFLH
KSTHGFAGDY SKFDGIGDPQ IYHSITQVVN NWYDDGEENA RTRHALISSI IHREGIVKEY
LFQYCQGMPS GFAMTVIFNS FVNYYYLAMA WMNLISHSPL SPQSTVRDFD NYCKVVVYGD
DNIVSVDLNF LEYYNLRTVA AYLSQFGVTY TDDAKNPIEK SVPFVEITSV SFLKRRWVPL
GGRLSTIYKA PLDKTSIEER LHWIRECDND IEALNQNIES ALYEASIHGK IYFGDLLQRI
RIACDAVMIP VPSVTFKDCH KRWWASMTGG ALDPASLSRL YLAAENQLVD TRKVWKDRFL
GEDRSLIDML KSARAVPLAA YHV
//
