ID O11H2_HUMAN Reviewed; 326 AA.
AC Q8NH07;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 24-JAN-2024, entry version 147.
DE RecName: Full=Olfactory receptor 11H2;
DE AltName: Full=Olfactory receptor OR14-1;
GN Name=OR11H2; Synonyms=C14orf15, OR11H2P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-12 is the initiator.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR11H2";
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DR EMBL; AB065607; BAC05834.1; -; Genomic_DNA.
DR EMBL; BK004489; DAA04887.1; -; Genomic_DNA.
DR RefSeq; NP_001184216.1; NM_001197287.1.
DR AlphaFoldDB; Q8NH07; -.
DR SMR; Q8NH07; -.
DR STRING; 9606.ENSP00000492923; -.
DR GlyCosmos; Q8NH07; 3 sites, No reported glycans.
DR GlyGen; Q8NH07; 3 sites.
DR BioMuta; OR11H2; -.
DR DMDM; 74760292; -.
DR PaxDb; 9606-ENSP00000485150; -.
DR DNASU; 79334; -.
DR GeneID; 79334; -.
DR KEGG; hsa:79334; -.
DR UCSC; uc058yqs.1; human.
DR AGR; HGNC:14716; -.
DR CTD; 79334; -.
DR GeneCards; OR11H2; -.
DR HGNC; HGNC:14716; OR11H2.
DR HPA; ENSG00000258453; Not detected.
DR neXtProt; NX_Q8NH07; -.
DR VEuPathDB; HostDB:ENSG00000258453; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NH07; -.
DR OMA; NMNISEP; -.
DR OrthoDB; 3040813at2759; -.
DR PhylomeDB; Q8NH07; -.
DR PathwayCommons; Q8NH07; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 79334; 10 hits in 196 CRISPR screens.
DR GenomeRNAi; 79334; -.
DR Pharos; Q8NH07; Tdark.
DR PRO; PR:Q8NH07; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NH07; Protein.
DR Bgee; ENSG00000258453; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR CDD; cd15913; 7tmA_OR11G-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR24242; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24242:SF201; OLFACTORY RECEPTOR 11H1-RELATED; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..326
FT /note="Olfactory receptor 11H2"
FT /id="PRO_0000332963"
FT TOPO_DOM 1..44
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..112
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..158
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..216
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..259
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..287
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..326
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 13
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 106
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 112..194
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 326 AA; 36531 MW; DC3B61F0F1A088D2 CRC64;
MCPLTLHVTG LMNVSEPNSS FAFVNEFILQ GFSCEWTIQI FLFSLFTTIY ALTITGNGAI
AFVLWCDRRL HTPMYMFLGN FSFLEIWYVS STVPKMLVNF LSEKKNISFA GCFLQFYFFF
SLGTSECLLL TVMAFDQYLA ICRPLLYPNI MTGHLYAKLV ILCWVCGFLW FLIPIVLISQ
KPFCGPNIID HVVCDPGPLF ALDCVSAPRI QLFCYTLSSL VIFGNFLFII GSYTLVLKAV
LGMPSSTGRH KAFSTCGSHL AVVSLCYSPL MVMYVSPGLG HSTGMQKIET LFYAMVTPLF
NPLIYSLQNK EIKAALRKVL GSSNII
//
