ID   O14729_HUMAN            Unreviewed;       588 AA.
AC   O14729;
DT   01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT   01-JAN-1998, sequence version 1.
DT   27-MAR-2024, entry version 82.
DE   SubName: Full=Smooth muscle myosin heavy chain SM2 {ECO:0000313|EMBL:AAB69326.1};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAB69326.1};
RN   [1] {ECO:0000313|EMBL:AAB69326.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Prostate {ECO:0000313|EMBL:AAB69326.1};
RX   PubMed=10906735;
RX   DOI=10.1002/1097-0045(20000801)44:3<193::AID-PROS3>3.0.CO;2-A;
RA   Lin V.K., Wang D., Lee I.L., Vasquez D., Fagelson J.E., McConnell J.D.;
RT   "Myosin heavy chain gene expression in normal and hyperplastic human
RT   prostate tissue.";
RL   Prostate 44:193-203(2000).
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DR   EMBL; AF013570; AAB69326.1; -; mRNA.
DR   AlphaFoldDB; O14729; -.
DR   PeptideAtlas; O14729; -.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0016459; C:myosin complex; IEA:InterPro.
DR   Gene3D; 1.20.5.340; -; 2.
DR   Gene3D; 6.10.250.2420; -; 1.
DR   InterPro; IPR002928; Myosin_tail.
DR   PANTHER; PTHR46349; CINGULIN-LIKE PROTEIN 1-RELATED; 1.
DR   PANTHER; PTHR46349:SF7; MYOSIN_TAIL_1 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01576; Myosin_tail_1; 1.
DR   SUPFAM; SSF90257; Myosin rod fragments; 3.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054}.
FT   DOMAIN          1..578
FT                   /note="Myosin tail"
FT                   /evidence="ECO:0000259|Pfam:PF01576"
FT   REGION          394..450
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          516..588
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        411..437
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        516..565
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAB69326.1"
SQ   SEQUENCE   588 AA;  68244 MW;  0B033C7CE10E6790 CRC64;
     QLNEEMEAKQ NLERHISTLN IQLSDSKKKL QDFASTVEAL EEGKKRFQKE IENLTQQYEE
     KAAAYDKLEK TKNRLQQELD DLVVDLDNQR QLVSNLEKKQ RKFDQLLAEE KNISSKYADE
     RDRAEAEARE KETKALSLAR ALEEALEAKE ELERTNKMLK AEMEDLVSSK DDVGKNVHEL
     EKSKRALETQ MEEMKTQLEE LEDELQATED AKLRLEVNMQ ALKGQFERDL QARDEQNEEK
     RRQLQRQLHE YETELEDERK QRALAAAAKK KLEGDLKDLE LQADSAIKGR EEAIKHVRKL
     QAQMKDFQRE LEDARASRDE IFATAKENEK KAKSLEADLM QLQEDLAAAE RARKQADLEK
     EELAEELASS LSGRNALQDE KRRLEARIAQ LEEELEEEQG NMEAMSDRVR KATQQAEQLS
     NELATERSTA QKNESARQQL ERQNKELRSK LHEMEGAVKS KFKSTIAALE AKIAQLEEQV
     EQEAREKQAA TKSLKQKDKK LKEILLQVED ERKMAEQYKE QAEKGNARVK QLKRQLEEAE
     EESQRINANR RKLQRELDEA TESNEAMGRE VNALKSKLRG PPPQETSQ
//