ID O16518_CAEEL Unreviewed; 493 AA.
AC O16518;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 2.
DT 27-MAR-2024, entry version 151.
DE RecName: Full=Aldehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036492};
GN Name=alh-4 {ECO:0000313|EMBL:CCD72037.1,
GN ECO:0000313|WormBase:T05H4.13a};
GN ORFNames=CELE_T05H4.13 {ECO:0000313|EMBL:CCD72037.1}, T05H4.13
GN {ECO:0000313|WormBase:T05H4.13a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD72037.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD72037.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD72037.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|PIRNR:PIRNR036492}.
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DR EMBL; BX284605; CCD72037.1; -; Genomic_DNA.
DR PIR; T31905; T31905.
DR RefSeq; NP_741553.1; NM_171471.5.
DR AlphaFoldDB; O16518; -.
DR SMR; O16518; -.
DR EPD; O16518; -.
DR PeptideAtlas; O16518; -.
DR EnsemblMetazoa; T05H4.13a.1; T05H4.13a.1; WBGene00000110.
DR GeneID; 179026; -.
DR KEGG; cel:CELE_T05H4.13; -.
DR UCSC; T05H4.13a; c. elegans.
DR AGR; WB:WBGene00000110; -.
DR WormBase; T05H4.13a; CE27441; WBGene00000110; alh-4.
DR HOGENOM; CLU_005391_3_1_1; -.
DR OrthoDB; 606537at2759; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00000110; Expressed in larva and 4 other cell types or tissues.
DR ExpressionAtlas; O16518; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR GO; GO:0006081; P:cellular aldehyde metabolic process; IBA:GO_Central.
DR CDD; cd07087; ALDH_F3-13-14_CALDH-like; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR012394; Aldehyde_DH_NAD(P).
DR PANTHER; PTHR43570; ALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43570:SF16; ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q; 1.
DR Pfam; PF00171; Aldedh; 1.
DR PIRSF; PIRSF036492; ALDH; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|PIRNR:PIRNR036492};
KW Proteomics identification {ECO:0007829|EPD:O16518,
KW ECO:0007829|PeptideAtlas:O16518};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 462..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..428
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 209
FT /evidence="ECO:0000256|PIRSR:PIRSR036492-1"
FT ACT_SITE 243
FT /evidence="ECO:0000256|PIRSR:PIRSR036492-1"
SQ SEQUENCE 493 AA; 55567 MW; 99B25D2DA5881015 CRC64;
MAFTELVETQ RKYFRTGETK PVKFRKQQLL KLKKFIEENR EALSEAVWKD LRRRHESTEI
LEIGMTIQEI DYFLKNIDDW VKPTHVEKTF TTALDKPVIE KDPKGVVLII SPWNYPVSMI
LLPMVPAIAA GNTVVIKPSE LSENVAATFE KLIPKYFESK YVTVVNGGIP ETTDLLKERF
DHILYTGCPP VAKIIMTAAA KHLTPVTLEL GGKCPVVVED DADIDISAKR IAWGKWLNCG
QTCLAPDYIL VNSTVKPKLV AAIRKYVNEF YGEDVKASKD YARMINQRHF DRISGLLDKT
QGAVLIGGER DRADLYIPPT VLDVEKSDPF MHDEIFGPVL PIITVQSFSE SLEYIADGEK
PLAAYIFTRN EAKVKRLLNE TSSGGVTVND VLMHITVDTL PFGGVGVSGM GRYRGKYGFD
TFTHEKSVLH RGFFGESLLA ARYPPLSQQK LDQMRRLTGK RISLNLMNVA TLPIVMASFV
FGMLFQKYAR NLH
//
