ID O16988_CAEEL Unreviewed; 515 AA.
AC O16988;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 151.
DE SubName: Full=Glucuronosyltransferase {ECO:0000313|EMBL:CCD71811.1};
GN Name=ugt-53 {ECO:0000313|EMBL:CCD71811.1,
GN ECO:0000313|WormBase:T03D3.1};
GN ORFNames=CELE_T03D3.1 {ECO:0000313|EMBL:CCD71811.1}, T03D3.1
GN {ECO:0000313|WormBase:T03D3.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD71811.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD71811.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD71811.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000301};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; BX284605; CCD71811.1; -; Genomic_DNA.
DR PIR; T32217; T32217.
DR RefSeq; NP_503771.1; NM_071370.3.
DR AlphaFoldDB; O16988; -.
DR SMR; O16988; -.
DR STRING; 6239.T03D3.1.1; -.
DR CAZy; GT1; Glycosyltransferase Family 1.
DR EPD; O16988; -.
DR PaxDb; 6239-T03D3-1; -.
DR PeptideAtlas; O16988; -.
DR EnsemblMetazoa; T03D3.1.1; T03D3.1.1; WBGene00020182.
DR GeneID; 178744; -.
DR KEGG; cel:CELE_T03D3.1; -.
DR UCSC; T03D3.1; c. elegans.
DR AGR; WB:WBGene00020182; -.
DR WormBase; T03D3.1; CE13068; WBGene00020182; ugt-53.
DR eggNOG; KOG1192; Eukaryota.
DR HOGENOM; CLU_012949_1_3_1; -.
DR InParanoid; O16988; -.
DR OMA; HRLEWLP; -.
DR OrthoDB; 2880257at2759; -.
DR PhylomeDB; O16988; -.
DR Reactome; R-CEL-9753281; Paracetamol ADME.
DR Reactome; R-CEL-9757110; Prednisone ADME.
DR Reactome; R-CEL-9840309; Glycosphingolipid biosynthesis.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00020182; Expressed in embryo and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IBA:GO_Central.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR InterPro; IPR002213; UDP_glucos_trans.
DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR PANTHER; PTHR48043:SF41; GLUCURONOSYLTRANSFERASE; 1.
DR Pfam; PF00201; UDPGT; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 479..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 515 AA; 58768 MW; 4ED5B48236B7CD71 CRC64;
MRLLIFLTVL INFSSCLNIL FYYAVIGPSH IAYLRNTIGK LLARGHNVDV VFAVYNELAN
LDLFPDVRRI YYNRHADPDY WKKNANHFSN MFEKSPTPLG EFEIFHESGY QLCKIAINDL
KLIEFLKSGK YDIGFSSDYD PCGNILMTAA GIPSIGSLIA TPIFLPHIVS AGLPTVASVY
GTSLYPEHDS SLYDKIFNLI RLTYYHYAIS PDMDRKYNNL ITKRFGNNFP DVGTIERGID
IIFVNSHDFL EQQRPMSPKI KYIGGMAIRK AKQLPDEFEK ILSVPKSAYV LFSFGTQVPT
AKMPLPIRRN FVGAFKKFPN VTFLWKYDSL ELDADIFQGV ENIHRLEWLP QTELLHDNRV
KLFISHMGLN SYLETATAGV PVLSIPLFAD QQNNAQNTRD RGMGLLLDRD KLTTKNIESA
LHELLENPKY LSNARSISKM ILEKPDKAND TFIHWLEFTA RNPGLGRVLK LPGAELSPFY
YYCGDILLLV FCILFIILHT VLRTINLPSR KIKSE
//
