ID O16992_CAEEL Unreviewed; 746 AA.
AC O16992;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1999, sequence version 2.
DT 27-MAR-2024, entry version 143.
DE SubName: Full=Choline/carnitine acyltransferase domain-containing protein {ECO:0000313|EMBL:CCD74278.1};
GN ORFNames=CELE_W03F9.4 {ECO:0000313|EMBL:CCD74278.1}, W03F9.4
GN {ECO:0000313|EMBL:CCD74278.1, ECO:0000313|WormBase:W03F9.4a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD74278.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD74278.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD74278.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232}.
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DR EMBL; BX284605; CCD74278.1; -; Genomic_DNA.
DR PIR; D88922; D88922.
DR RefSeq; NP_503145.1; NM_070744.3.
DR AlphaFoldDB; O16992; -.
DR SMR; O16992; -.
DR STRING; 6239.W03F9.4a.2; -.
DR EPD; O16992; -.
DR PaxDb; 6239-W03F9-4; -.
DR PeptideAtlas; O16992; -.
DR EnsemblMetazoa; W03F9.4a.1; W03F9.4a.1; WBGene00021002.
DR GeneID; 178543; -.
DR KEGG; cel:CELE_W03F9.4; -.
DR UCSC; W03F9.4; c. elegans.
DR AGR; WB:WBGene00021002; -.
DR WormBase; W03F9.4a; CE21255; WBGene00021002; -.
DR eggNOG; KOG3716; Eukaryota.
DR GeneTree; ENSGT01060000248595; -.
DR HOGENOM; CLU_013513_2_1_1; -.
DR InParanoid; O16992; -.
DR OMA; FWPAGGF; -.
DR OrthoDB; 2874530at2759; -.
DR PhylomeDB; O16992; -.
DR Reactome; R-CEL-200425; Carnitine metabolism.
DR Reactome; R-CEL-5362517; Signaling by Retinoic Acid.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00021002; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR ExpressionAtlas; O16992; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004095; F:carnitine O-palmitoyltransferase activity; IBA:GO_Central.
DR GO; GO:0009437; P:carnitine metabolic process; IBA:GO_Central.
DR GO; GO:0006631; P:fatty acid metabolic process; IBA:GO_Central.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589:SF104; CARN_ACYLTRANSF DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
PE 1: Evidence at protein level;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000313|EMBL:CCD74278.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:O16992};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 151..729
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 446
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 746 AA; 85925 MW; 95AB58718A92299D CRC64;
MSKTTRPISL NRIVQRNVRY CAKQLEYFLF PVLTREVVFF LTLWTVLDAL EMNFMNLAPK
SLEVMAFGII GTSLLAQTLV SLLIGTVTAL TVITVIRCSL IMMLYYNGWL FEEIGKKPSY
ATTAFFVILG FISKRATFFS YQGILPWLLP PKVEDTVAKY LQTMKPILGE KEFLELSEQA
EEFKSTIAGG LQNKLWMKWA VSKNYLSDWW KEVVYMRYRD SLIRTNVGCA DVIYQKTTSN
QAARAAYVTL NRQHFCNDIF KSEKMKPVSL GGIPLCAQQY AEYYRTLRIP HETSDKMIRL
PDAKHIAVYH KGCWYKIDIF HGKRMVKPSE LEKSFQEILD SNDHISQQGE KYLSALTIGP
RDLWARIRTE KFSKGGVNQE SLSFIENSLE IVFLDEEERF FDEDDSTKYG REYARALHGD
GYMLWCDKPS VYIFSKNGRF SSNAEHSPCD AMIYVQVREY IKYHEQFESP YGPDGHCVGS
IEHVPKAERL CWDMDKETLD AIDEAFIISK GVADDFSNAN VVFTEYGKDF MKKAKVSPDA
YIQMALQMAY FKDQGKFEQT YEPAVMRLFK EGRTETVRSC SIWSCDFVRT MLKKDVGAGK
KLEKLKEACD HHQDYYRTAM AGKGVDRHLF ALYVVARYLE IKTPFLENVF GRNWSLSTSQ
TPQHQMVEYA KALNKEPSLF WPAGGFACPD GSNYGVCYTI GTTGDRMSFH VTTWNSLENT
DSARFLKHIL ESLREIKDVV EEATRK
//
