ID O18009_CAEEL Unreviewed; 535 AA.
AC O18009;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 143.
DE RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
GN Name=ugt-30 {ECO:0000313|EMBL:CAB03266.1,
GN ECO:0000313|WormBase:T01G5.2};
GN ORFNames=CELE_T01G5.2 {ECO:0000313|EMBL:CAB03266.1}, T01G5.2
GN {ECO:0000313|WormBase:T01G5.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB03266.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAB03266.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB03266.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000301,
CC ECO:0000256|RuleBase:RU362059};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167,
CC ECO:0000256|RuleBase:RU362059}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167, ECO:0000256|RuleBase:RU362059}.
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR EMBL; BX284605; CAB03266.1; -; Genomic_DNA.
DR PIR; T24309; T24309.
DR RefSeq; NP_506729.1; NM_074328.1.
DR AlphaFoldDB; O18009; -.
DR SMR; O18009; -.
DR CAZy; GT1; Glycosyltransferase Family 1.
DR PaxDb; 6239-T01G5-2; -.
DR PeptideAtlas; O18009; -.
DR EnsemblMetazoa; T01G5.2.1; T01G5.2.1; WBGene00011340.
DR GeneID; 187955; -.
DR KEGG; cel:CELE_T01G5.2; -.
DR UCSC; T01G5.2; c. elegans.
DR AGR; WB:WBGene00011340; -.
DR WormBase; T01G5.2; CE12976; WBGene00011340; ugt-30.
DR eggNOG; KOG1192; Eukaryota.
DR GeneTree; ENSGT00940000170294; -.
DR HOGENOM; CLU_012949_1_4_1; -.
DR InParanoid; O18009; -.
DR OMA; EILDVWW; -.
DR OrthoDB; 382054at2759; -.
DR PhylomeDB; O18009; -.
DR Reactome; R-CEL-9753281; Paracetamol ADME.
DR Reactome; R-CEL-9757110; Prednisone ADME.
DR Reactome; R-CEL-9840309; Glycosphingolipid biosynthesis.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00011340; Expressed in adult organism and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IBA:GO_Central.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR PANTHER; PTHR48043:SF14; GLUCURONOSYLTRANSFERASE-RELATED; 1.
DR Pfam; PF00201; UDPGT; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS00375; UDPGT; 1.
PE 1: Evidence at protein level;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU003718}; Membrane {ECO:0000256|RuleBase:RU362059};
KW Proteomics identification {ECO:0007829|EPD:O18009};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU362059};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718};
KW Transmembrane {ECO:0000256|RuleBase:RU362059};
KW Transmembrane helix {ECO:0000256|RuleBase:RU362059}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|RuleBase:RU362059"
FT CHAIN 19..535
FT /note="UDP-glucuronosyltransferase"
FT /evidence="ECO:0000256|RuleBase:RU362059"
FT /id="PRO_5005142208"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362059"
SQ SEQUENCE 535 AA; 60811 MW; F338B62BA63B5548 CRC64;
MLYLQSIIFF CLLLYSNCLN ILVYAPAFAA SHSKFLGKLA DTLTERGHNV TYLMPVVNIA
KRDECKGVKI TKDVVIVEAG EKMLSQKQAD TPNDEILDVW WTVQMDSSNS REIFQFFCSD
MKIACENFLS RRDIFEDMKA RNFDLAILEP VSACGLGFVK ALGIEKTILA SSSVFYDVIL
PYIGEPLDYS YVPSGYSVTG QELSLGEKFE NWMVSREISI ALEGLFDGEM EIYRRLLGHN
LTNWRHLFPS ASIFFVNSNP FFDFPRPVLE KTVPIGGISV NMGVRKEDML TEEWEKVLNQ
RPHTMLVSFG TLVMSTHMPK KWRSGLLEAF KSFPNVTFIW KYESDDHSFA NGIDNIYFSK
WVPQNELLND NRLTAFLSHG GLGSIMELAF SGKPALIIPV FADQTRNANT LARHRGAICL
HKSQMKNTEV LKKAFKSVLF DASFKNNSLK LAATLRNQPN KPKDTLIKYT EFVGEFGPFP
QMDPYGRHLN VFQKSFIDIY TLIIVVSSIF VALIFNVIAK LIQYFIKSKS SEKND
//
