ID O18710_9TRYP Unreviewed; 422 AA.
AC O18710;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00012418};
DE EC=2.7.7.6 {ECO:0000256|ARBA:ARBA00012418};
DE Flags: Fragment;
OS Leishmania adleri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC lizard Leishmania.
OX NCBI_TaxID=5674 {ECO:0000313|EMBL:AAC47782.1};
RN [1] {ECO:0000313|EMBL:AAC47782.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RLIZ/KE/XX/LV30 {ECO:0000313|EMBL:AAC47782.1};
RX PubMed=9364962; DOI=10.1016/S0166-6851(97)00111-4;
RA Croan D.G., Morrison D.A., Ellis J.T.;
RT "Evolution of the genus Leishmania revealed by comparison of DNA and RNA
RT polymerase gene sequences.";
RL Mol. Biochem. Parasitol. 89:149-159(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550};
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DR EMBL; AF009153; AAC47782.1; -; Genomic_DNA.
DR AlphaFoldDB; O18710; -.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.30.1360.140; -; 1.
DR Gene3D; 6.20.50.80; -; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR007075; RNA_pol_Rpb1_6.
DR InterPro; IPR007073; RNA_pol_Rpb1_7.
DR InterPro; IPR038593; RNA_pol_Rpb1_7_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF37; DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR Pfam; PF04992; RNA_pol_Rpb1_6; 1.
DR Pfam; PF04990; RNA_pol_Rpb1_7; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 4: Predicted;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..327
FT /note="RNA polymerase Rpb1"
FT /evidence="ECO:0000259|Pfam:PF04998"
FT DOMAIN 43..244
FT /note="RNA polymerase Rpb1"
FT /evidence="ECO:0000259|Pfam:PF04992"
FT DOMAIN 328..408
FT /note="RNA polymerase Rpb1"
FT /evidence="ECO:0000259|Pfam:PF04990"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAC47782.1"
FT NON_TER 422
FT /evidence="ECO:0000313|EMBL:AAC47782.1"
SQ SEQUENCE 422 AA; 48398 MW; 99882AE373627F34 CRC64;
TSDTGYLQRK RVKALEDVHA SYDGTVRNAN EELIQLVYGE DGLDGARIEG NQAFPIPHMT
NSEMADKYRY EYNDEGSFSE NMGGHYMDPF VRDSLLRDPQ SVLKLQEEYD QLVKDRAMSR
LVIDMEDKNK LKMNLPVNVA RLIQNARTTM GKRSQVSNLN PITVINRVRE LQEDLVQLFP
SYHKDYNGRF LNVLSQQRVE RAVMLFGIHL RQILGSKRVL KEYKLNDKAF EYLLKEIRTK
YQQSLITPGE VIGAIAAQSC GEPATQMTLN TFHNAGISSK NVTLGVPRLL ELLNVSKNQR
NASVAVCLIR EYQKRNKAQE AQQFIEYCTL ANITTTVQII YDPDLRNTVV AEDEEMIRWE
QAVMNEEDEE LDAEQPPSPF IARLILDNDL FNDKRLNMKD VKSAIRQVDS SYMVQANMEN
DG
//
