ID O32625_HAEIF Unreviewed; 792 AA.
AC O32625;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 24-JAN-2024, entry version 83.
DE RecName: Full=Outer membrane protein assembly factor BamA {ECO:0000256|HAMAP-Rule:MF_01430};
DE Flags: Precursor;
GN Name=d15 {ECO:0000313|EMBL:AAB61969.1};
GN Synonyms=bamA {ECO:0000256|HAMAP-Rule:MF_01430,
GN ECO:0000313|EMBL:PRK67666.1};
GN ORFNames=BV163_00047 {ECO:0000313|EMBL:PRK67666.1};
OS Haemophilus influenzae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=727 {ECO:0000313|EMBL:AAB61969.1};
RN [1] {ECO:0000313|EMBL:AAB61969.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9284140;
RA Loosmore S.M., Yang Y.P., Coleman D.C., Shortreed J.M., England D.M.,
RA Klein M.H.;
RT "Outer membrane protein D15 is conserved among Haemophilus influenzae
RT species and may represent a universal protective antigen against invasive
RT disease.";
RL Infect. Immun. 65:3701-3707(1997).
RN [2] {ECO:0000313|EMBL:PRK67666.1, ECO:0000313|Proteomes:UP000237977}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=84P15H4 {ECO:0000313|EMBL:PRK67666.1,
RC ECO:0000313|Proteomes:UP000237977};
RA Murphy T.F., Kong Y., Nadendla S., Tettelin H., Pettigrew M.;
RT "Haemophilus influenzae in COPD genome sequencing project.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the outer membrane protein assembly complex, which is
CC involved in assembly and insertion of beta-barrel proteins into the
CC outer membrane. {ECO:0000256|HAMAP-Rule:MF_01430}.
CC -!- SUBUNIT: Part of the Bam complex. {ECO:0000256|HAMAP-Rule:MF_01430}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000256|HAMAP-
CC Rule:MF_01430}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the BamA family. {ECO:0000256|HAMAP-
CC Rule:MF_01430}.
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DR EMBL; U60831; AAB61969.1; -; Genomic_DNA.
DR EMBL; MZHU01000001; PRK67666.1; -; Genomic_DNA.
DR RefSeq; WP_005690570.1; NZ_QQKZ01000001.1.
DR AlphaFoldDB; O32625; -.
DR Proteomes; UP000237977; Unassembled WGS sequence.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProtKB-UniRule.
DR Gene3D; 3.10.20.310; membrane protein fhac; 5.
DR Gene3D; 2.40.160.50; membrane protein fhac: a member of the omp85/tpsb transporter family; 1.
DR HAMAP; MF_01430; OM_assembly_BamA; 1.
DR InterPro; IPR000184; Bac_surfAg_D15.
DR InterPro; IPR010827; BamA/TamA_POTRA.
DR InterPro; IPR039910; D15-like.
DR InterPro; IPR023707; OM_assembly_BamA.
DR InterPro; IPR034746; POTRA.
DR NCBIfam; TIGR03303; OM_YaeT; 1.
DR PANTHER; PTHR12815:SF23; OUTER MEMBRANE PROTEIN ASSEMBLY FACTOR BAMA; 1.
DR PANTHER; PTHR12815; SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF01103; Omp85; 1.
DR Pfam; PF07244; POTRA; 4.
DR PIRSF; PIRSF006076; OM_assembly_OMP85; 1.
DR PROSITE; PS51779; POTRA; 5.
PE 3: Inferred from homology;
KW Cell outer membrane {ECO:0000256|HAMAP-Rule:MF_01430};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01430};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|HAMAP-Rule:MF_01430};
KW Signal {ECO:0000256|HAMAP-Rule:MF_01430};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01430};
KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452,
KW ECO:0000256|HAMAP-Rule:MF_01430}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01430"
FT CHAIN 20..792
FT /note="Outer membrane protein assembly factor BamA"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01430"
FT /id="PRO_5034791279"
FT DOMAIN 22..89
FT /note="POTRA"
FT /evidence="ECO:0000259|PROSITE:PS51779"
FT DOMAIN 90..170
FT /note="POTRA"
FT /evidence="ECO:0000259|PROSITE:PS51779"
FT DOMAIN 173..259
FT /note="POTRA"
FT /evidence="ECO:0000259|PROSITE:PS51779"
FT DOMAIN 262..341
FT /note="POTRA"
FT /evidence="ECO:0000259|PROSITE:PS51779"
FT DOMAIN 344..418
FT /note="POTRA"
FT /evidence="ECO:0000259|PROSITE:PS51779"
SQ SEQUENCE 792 AA; 87379 MW; 84BECB2DC4814C7F CRC64;
MKKLLIASLL FGTTTTVFAA PFVAKDIRVD GVQGDLEQQI RASLPVRAGQ RVTDNDVANI
VRSLFVSGRF DDVKAHQEGD VLVVSVVAKS IISDVKIKGN SIIPTEALKQ NLDANGFKVG
DILIREKLNE FAKSVKEHYA SVGRYNATVE PIVNTLPNNR AEILIQINED DKAKLASLTF
KGNESVSSST LQEQMELQPD SWWKLWGNKF EGAQFEKDLQ AIRDYYLNNG YAKAQITKTD
VQLNDEKTKV NVTIDVNEGL QYDLRSARII GNLGGMSAEL EPLLSALHLN DTFRRSDIAD
VENAIKAKLG ERGYGNTTVN SVPDFDDANK TLAITFVVDA GRRLTVHQLR FEGNTVSADS
TLRQEMRQQE GTWYNSQLVE LGKIRLDRTG FFETVENRID PINGSNDEVD VVYKVKERNT
GSINFGIGYG TESGISYQAS VKQDNFLGTG AAVSIAGTKN DYGTSVNLGY TEPYFTKDGV
SLGGNVFFEN YDNSKSDTSS NYKRTTYGSN VTLGFPVNEN NSYYVGLGHT YNKISNFALE
YNRNLYIQSM KFKGNGIKTN DFDFSFGWNY NSLNRGYFPT KGVKASLGGR VTIPGSDNKY
YKLSADVQGF YPLDRDHLWV VSAKASAGYA NGFGNKRLPF YQTYTAGGIG SLRGFAYGSI
GPNAIYQGQN NKFNKISSDV IGGNAIATAS AELIVPTPFV SDKSQNTVRT SLFVDAASVW
NTKWKSDKNG LESNVLKDLP DYGKSSRIRA STGVGFQWQS PIGPLVFSYA KPIKKYENDD
VEQFQFSIGG SF
//
