ID O45003_CAEEL Unreviewed; 430 AA.
AC O45003;
DT 01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2004, sequence version 2.
DT 27-MAR-2024, entry version 161.
DE SubName: Full=BAAT/acyl-CoA thioester hydrolase protein {ECO:0000313|EMBL:CCD73381.1};
GN ORFNames=CELE_W03D8.8 {ECO:0000313|EMBL:CCD73381.1}, W03D8.8
GN {ECO:0000313|EMBL:CCD73381.1, ECO:0000313|WormBase:W03D8.8};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD73381.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD73381.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD73381.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the C/M/P thioester hydrolase family.
CC {ECO:0000256|ARBA:ARBA00006538}.
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DR EMBL; BX284601; CCD73381.1; -; Genomic_DNA.
DR PIR; T32937; T32937.
DR RefSeq; NP_491047.2; NM_058646.2.
DR AlphaFoldDB; O45003; -.
DR SMR; O45003; -.
DR DIP; DIP-24780N; -.
DR IntAct; O45003; 7.
DR STRING; 6239.W03D8.8.1; -.
DR ESTHER; caeel-W03D8.8; Acyl-CoA_Thioesterase.
DR MEROPS; S09.B10; -.
DR EPD; O45003; -.
DR PaxDb; 6239-W03D8-8; -.
DR PeptideAtlas; O45003; -.
DR EnsemblMetazoa; W03D8.8.1; W03D8.8.1; WBGene00020989.
DR GeneID; 189157; -.
DR KEGG; cel:CELE_W03D8.8; -.
DR UCSC; W03D8.8; c. elegans.
DR AGR; WB:WBGene00020989; -.
DR WormBase; W03D8.8; CE36212; WBGene00020989; -.
DR eggNOG; ENOG502QQ8Z; Eukaryota.
DR GeneTree; ENSGT01010000222336; -.
DR HOGENOM; CLU_029849_4_0_1; -.
DR InParanoid; O45003; -.
DR OMA; RPFLWGG; -.
DR OrthoDB; 5356064at2759; -.
DR PhylomeDB; O45003; -.
DR Reactome; R-CEL-159418; Recycling of bile acids and salts.
DR Reactome; R-CEL-193368; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
DR Reactome; R-CEL-390247; Beta-oxidation of very long chain fatty acids.
DR Reactome; R-CEL-77289; Mitochondrial Fatty Acid Beta-Oxidation.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00020989; Expressed in larva and 1 other cell type or tissue.
DR GO; GO:0047617; F:acyl-CoA hydrolase activity; IBA:GO_Central.
DR GO; GO:0006637; P:acyl-CoA metabolic process; IBA:GO_Central.
DR GO; GO:0006631; P:fatty acid metabolic process; IBA:GO_Central.
DR Gene3D; 2.60.40.2240; Acyl-CoA thioester hydrolase/BAAT N-terminal domain; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR016662; Acyl-CoA_thioEstase_long-chain.
DR InterPro; IPR014940; BAAT_C.
DR InterPro; IPR006862; Thio_Ohase/aa_AcTrfase.
DR InterPro; IPR042490; Thio_Ohase/BAAT_N.
DR PANTHER; PTHR10824; ACYL-COENZYME A THIOESTERASE-RELATED; 1.
DR PANTHER; PTHR10824:SF10; PROTEIN CBG04103; 1.
DR Pfam; PF08840; BAAT_C; 1.
DR Pfam; PF04775; Bile_Hydr_Trans; 1.
DR PIRSF; PIRSF016521; Acyl-CoA_hydro; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 1: Evidence at protein level;
KW Hydrolase {ECO:0000313|EMBL:CCD73381.1};
KW Proteomics identification {ECO:0007829|EPD:O45003,
KW ECO:0007829|PeptideAtlas:O45003};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 14..135
FT /note="Acyl-CoA thioester hydrolase/bile acid-CoA amino
FT acid N-acetyltransferase"
FT /evidence="ECO:0000259|Pfam:PF04775"
FT DOMAIN 196..407
FT /note="BAAT/Acyl-CoA thioester hydrolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08840"
FT ACT_SITE 224
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR016521-1"
FT ACT_SITE 324
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR016521-1"
FT ACT_SITE 356
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR016521-1"
SQ SEQUENCE 430 AA; 48793 MW; C0F5717A4A6B44ED CRC64;
MPIHVDKPDT MQNELIDIVA DGLRSNQIYT FRMILKHDYG THKSEATFQA DPAGRIDLKY
AKPLRGSYYD ADPMGLFLGM KPCEDFAYGG YLRCTPPVPF YYLLELFDSS GTLIDSTYIK
KHWMHPKLIR TELEEDFCAT LFKPPGDGPF PVVLDISGTG GGIHEHKGAM LASEGFVVLC
LAFFQFKYLP QKMEDVDMEY FAKAINYLID LPFTKNVIGI QGVSFGATIV DLLTTRHGDK
IKALVSINGP QVVSDYLFMQ ENGAPIPHLS HGQVTLEHCQ FINGVMCSHR NFQIMTEKLT
PETEIPWERI PSDVKIRVIG SVDDLCQPSV HATYYRQRRL KETGHDVEVE LVNGGHIMEP
PYFPHHELVY AKYQGFYCGY GGEVVLHAKS QEKTWSNTIK FFQKALGNTK KIQDWDRLTV
VVPPRKKSKL
//
