ID O45033_SCHJA Unreviewed; 760 AA.
AC O45033;
DT 01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JUN-1998, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Calpain {ECO:0000313|EMBL:AAC00514.1};
DE Flags: Fragment;
OS Schistosoma japonicum (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6182 {ECO:0000313|EMBL:AAC00514.1};
RN [1] {ECO:0000313|EMBL:AAC00514.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Philippine {ECO:0000313|EMBL:AAC00514.1};
RX PubMed=11227760; DOI=10.1016/S1383-5769(99)00021-5;
RA Scott J.C., McManus D.P.;
RT "Characterisation and expression of a cDNA encoding the 80-kDa large
RT subunit of Schistosoma japonicum calpain.";
RL Parasitol. Int. 48:205-214(2000).
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
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DR EMBL; AF044407; AAC00514.1; -; mRNA.
DR AlphaFoldDB; O45033; -.
DR MEROPS; C02.023; -.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00214; Calpain_III; 1.
DR CDD; cd00044; CysPc; 1.
DR CDD; cd16182; EFh_PEF_Group_II_CAPN_like; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR033883; C2_III.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF426; CALPAIN CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 2: Evidence at transcript level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU00239};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW ProRule:PRU00239}.
FT DOMAIN 101..399
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT DOMAIN 660..695
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT ACT_SITE 156
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 315
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 339
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAC00514.1"
SQ SEQUENCE 760 AA; 86834 MW; DC4C189F84561DB9 CRC64;
ITKGRIQIVY SPDANVSGRV NHPGKEVVDP RSGKVIKVKR QTPDDYLNVL KPVKGPKRLE
FNPYLPKTLT PKGYAKLKLM MSIASKQYET LVKNTKAEGI LWEDPDFPAN QDSIGNVQDI
GVQLEWKRPH EIISNAKFFS DGASRFDIKQ GALGDCWLLA VVASISGYPQ LFNQVVLKDQ
ELKGPNYVGV IRFRFWRFGQ WVEVLIDDRL PVRRGSNQLV FMHSSDPTEF WSALLEKAYA
KLNGCYAHLS GGTQSEAMED LTGGICLSIE LNQNERPQDL IEQLKIYAQR CCLMGCSIDS
TVIEQRLNDG LIAGHAYSLT GVYPVNYRGR TQWLMRLRNP WGDSHEWKGA WCDGAPQWRE
ISQKEKENIH LNFTEDGEFW MSFEDFVTCF SRVEVCHLGL ESLEFNQDFH GKRRLEEAIF
SGQWQRNVNA GGCINNRTTY WTNPQFLITV EDPDPDDNDN KCSILVALMQ KETRKKVGAD
FQPIGFMVYA VPDDQTTLMS RAQLLTKTPI AKSQFINTRE VVGQFRVPPG RYVIIPSTFD
PHIEANFILR VISQIPITEQ ELDEDNTNRG LPDDIIESLK LEDTLLDEDK EIEMRFMALR
DPKTLAIDAT KMGELLNNST LQDMPSFKGF NKELCRSMVA SVDNNLTGLV ELDEFMDLWI
QAKGWKHIFL KHDIDQSGYF DAYELREALN DAGFRVSNLL FNAIAHRYTD PGTDKISFED
FMLCMVRLKT AFETIEAHPK NLEGTSLFMK EDYLRFTVSI
//
