ID O45891_CAEEL Unreviewed; 444 AA.
AC O45891;
DT 01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JUN-1998, sequence version 1.
DT 27-MAR-2024, entry version 157.
DE SubName: Full=Potassium channel domain-containing protein {ECO:0000313|EMBL:CAB04923.1};
GN Name=twk-42 {ECO:0000313|EMBL:CAB04923.1,
GN ECO:0000313|WormBase:W06D12.2};
GN ORFNames=CELE_W06D12.2 {ECO:0000313|EMBL:CAB04923.1}, W06D12.2
GN {ECO:0000313|WormBase:W06D12.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB04923.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAB04923.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB04923.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR EMBL; BX284605; CAB04923.1; -; Genomic_DNA.
DR PIR; T26229; T26229.
DR RefSeq; NP_507483.1; NM_075082.5.
DR AlphaFoldDB; O45891; -.
DR EPD; O45891; -.
DR PaxDb; 6239-W06D12-2; -.
DR EnsemblMetazoa; W06D12.2.1; W06D12.2.1; WBGene00006692.
DR EnsemblMetazoa; W06D12.2.2; W06D12.2.2; WBGene00006692.
DR EnsemblMetazoa; W06D12.2.3; W06D12.2.3; WBGene00006692.
DR GeneID; 180163; -.
DR KEGG; cel:CELE_W06D12.2; -.
DR UCSC; W06D12.2; c. elegans.
DR AGR; WB:WBGene00006692; -.
DR WormBase; W06D12.2; CE16550; WBGene00006692; twk-42.
DR eggNOG; KOG1418; Eukaryota.
DR HOGENOM; CLU_754860_0_0_1; -.
DR InParanoid; O45891; -.
DR OMA; INILNDW; -.
DR OrthoDB; 2877338at2759; -.
DR PhylomeDB; O45891; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00006692; Expressed in larva and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR PANTHER; PTHR11003:SF324; TWIK FAMILY OF POTASSIUM CHANNELS; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 1: Evidence at protein level;
KW Ion channel {ECO:0000256|RuleBase:RU003857, ECO:0000313|EMBL:CAB04923.1};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:O45891};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 105..165
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 231..303
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 393..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 444 AA; 51190 MW; 9129B55209428D9A CRC64;
MFWNLVAVNY ERYHLHHLVK IGVLIVYSFL GAGLFVLCEA ENEKSLKHED NMRVLRTSIA
AKQVFVQRLQ NMYSGNGSSS EFSETKLRRV LSEYDAAMGI SIDSKMKTRW DIWGGLYYAG
TIYTTIGYGD LAAETIWGRI CTMLYAMIGI PIVINILNDW GNMLFYFVDH FWQNIGRQWI
QSLRQKLRRR KVQSLEEGSI DKTPLMETSS TPPSPQNPNG TRPIPLLLVL IVLFFWMIQC
VAYFAYFENW TLFESVYFFF ISMTTIGFGD FTPSHTVAVG GIVFILGGLS VVSMCINVIQ
MQLEFIFNQI VQRIENDFKN TLSVAAEESR KKSIGVSEFG SIDPSKKKTM RTDGNVAEKY
SENMEMGNKL LMRFMSNHQK KMLNEKFDER AKMRNSGTQT TSQIKVASVQ TAERYEQTWD
EDPEEEQPKS RINTRRLYIY NTGE
//
