ID O51B6_HUMAN Reviewed; 312 AA.
AC Q9H340;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 24-JAN-2024, entry version 154.
DE RecName: Full=Olfactory receptor 51B6;
DE AltName: Full=Odorant receptor HOR5'beta6;
GN Name=OR51B6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS THR-5; SER-40; THR-90;
RP ILE-131; GLY-145; ALA-169; PHE-172; LEU-192 AND ARG-275.
RX PubMed=11121057; DOI=10.1073/pnas.97.26.14560;
RA Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M.,
RA Felsenfeld G., Groudine M., Hardison R.;
RT "Comparative structural and functional analysis of the olfactory receptor
RT genes flanking the human and mouse beta-globin gene clusters.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51B6";
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DR EMBL; AF137396; AAG41682.1; -; Genomic_DNA.
DR EMBL; AC104389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS31379.1; -.
DR RefSeq; NP_001004750.1; NM_001004750.1.
DR AlphaFoldDB; Q9H340; -.
DR SMR; Q9H340; -.
DR STRING; 9606.ENSP00000369568; -.
DR GlyCosmos; Q9H340; 1 site, No reported glycans.
DR GlyGen; Q9H340; 1 site.
DR iPTMnet; Q9H340; -.
DR PhosphoSitePlus; Q9H340; -.
DR BioMuta; OR51B6; -.
DR DMDM; 209572656; -.
DR PaxDb; 9606-ENSP00000369568; -.
DR PeptideAtlas; Q9H340; -.
DR Antibodypedia; 57755; 115 antibodies from 21 providers.
DR DNASU; 390058; -.
DR Ensembl; ENST00000380219.1; ENSP00000369568.1; ENSG00000176239.7.
DR GeneID; 390058; -.
DR KEGG; hsa:390058; -.
DR MANE-Select; ENST00000380219.1; ENSP00000369568.1; NM_001004750.1; NP_001004750.1.
DR UCSC; uc010qzb.2; human.
DR AGR; HGNC:19600; -.
DR CTD; 390058; -.
DR DisGeNET; 390058; -.
DR GeneCards; OR51B6; -.
DR HGNC; HGNC:19600; OR51B6.
DR HPA; ENSG00000176239; Not detected.
DR neXtProt; NX_Q9H340; -.
DR OpenTargets; ENSG00000176239; -.
DR PharmGKB; PA134989095; -.
DR VEuPathDB; HostDB:ENSG00000176239; -.
DR eggNOG; ENOG502RTZQ; Eukaryota.
DR GeneTree; ENSGT01100000263554; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q9H340; -.
DR OMA; NDHNLHE; -.
DR OrthoDB; 4578140at2759; -.
DR PhylomeDB; Q9H340; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q9H340; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q9H340; -.
DR BioGRID-ORCS; 390058; 9 hits in 739 CRISPR screens.
DR GeneWiki; OR51B6; -.
DR GenomeRNAi; 390058; -.
DR Pharos; Q9H340; Tdark.
DR PRO; PR:Q9H340; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9H340; Protein.
DR Bgee; ENSG00000176239; Expressed in sural nerve and 2 other cell types or tissues.
DR Genevisible; Q9H340; HS.
DR GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR CDD; cd15222; 7tmA_OR51-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR26450:SF22; OLFACTORY RECEPTOR 51B6; 1.
DR PANTHER; PTHR26450; OLFACTORY RECEPTOR 56B1-RELATED; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 51B6"
FT /id="PRO_0000150748"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 5
FT /note="K -> T (in dbSNP:rs4910755)"
FT /evidence="ECO:0000269|PubMed:11121057"
FT /id="VAR_053312"
FT VARIANT 40
FT /note="N -> S (in dbSNP:rs4910756)"
FT /evidence="ECO:0000269|PubMed:11121057"
FT /id="VAR_053313"
FT VARIANT 90
FT /note="I -> T (in dbSNP:rs7483122)"
FT /evidence="ECO:0000269|PubMed:11121057"
FT /id="VAR_053314"
FT VARIANT 123
FT /note="T -> A (in dbSNP:rs5006889)"
FT /id="VAR_053315"
FT VARIANT 125
FT /note="R -> H (in dbSNP:rs7479477)"
FT /id="VAR_060035"
FT VARIANT 126
FT /note="S -> N (in dbSNP:rs5006888)"
FT /id="VAR_060036"
FT VARIANT 131
FT /note="T -> I (in dbSNP:rs5006887)"
FT /evidence="ECO:0000269|PubMed:11121057"
FT /id="VAR_053316"
FT VARIANT 145
FT /note="R -> G (in dbSNP:rs5006886)"
FT /evidence="ECO:0000269|PubMed:11121057"
FT /id="VAR_053317"
FT VARIANT 169
FT /note="S -> A (in dbSNP:rs5006885)"
FT /evidence="ECO:0000269|PubMed:11121057"
FT /id="VAR_053318"
FT VARIANT 172
FT /note="L -> F (in dbSNP:rs5006884)"
FT /evidence="ECO:0000269|PubMed:11121057"
FT /id="VAR_053319"
FT VARIANT 192
FT /note="F -> L (in dbSNP:rs5006883)"
FT /evidence="ECO:0000269|PubMed:11121057"
FT /id="VAR_053320"
FT VARIANT 254
FT /note="V -> L (in dbSNP:rs7106330)"
FT /id="VAR_053321"
FT VARIANT 275
FT /note="S -> R (in dbSNP:rs5024042)"
FT /evidence="ECO:0000269|PubMed:11121057"
FT /id="VAR_053322"
FT CONFLICT 123..126
FT /note="TIRS -> AIHN (in Ref. 1; AAG41682)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 312 AA; 35269 MW; E7CCFDBD1FA50B45 CRC64;
MGLNKSASTF QLTGFPGMEK AHHWIFIPLL AAYISILLGN GTLLFLIRND HNLHEPMYYF
LAMLAATDLG VTLTTMPTVL GVLWLDHREI GHGACFSQAY FIHTLSVMES GVLLAMAYDC
FITIRSPLRY TSILTNTQVM KIGVRVLTRA GLSIMPIVVR LHWFPYCRSH VLSHAFCLHQ
DVIKLACADI TFNRLYPVVV LFAMVLLDFL IIFFSYILIL KTVMGIGSGG ERAKALNTCV
SHICCILVFY VTVVCLTFIH RFGKHVPHVV HITMSYIHFL FPPFMNPFIY SIKTKQIQSG
ILRLFSLPHS RA
//
