ID O69259_BORPT Unreviewed; 910 AA.
AC O69259;
DT 01-AUG-1998, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 2.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=P.69C protein {ECO:0000313|EMBL:CAA09475.1};
DE SubName: Full=Pertactin {ECO:0000313|EMBL:AAK92093.1, ECO:0000313|EMBL:CAA06898.2};
GN Name=prn {ECO:0000313|EMBL:CAA06898.2};
GN Synonyms=prn3 {ECO:0000313|EMBL:CAA09475.1}, prnA
GN {ECO:0000313|EMBL:AAK92093.1};
OS Bordetella pertussis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Bordetella.
OX NCBI_TaxID=520 {ECO:0000313|EMBL:CAA06898.2};
RN [1] {ECO:0000313|EMBL:CAA09475.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B343 {ECO:0000313|EMBL:CAA09475.1};
RX PubMed=9453625;
RA Mooi F.R., van Oirschot H., Heuvelman K., van der Heide H.G., Gaastra W.,
RA Willems R.J.;
RT "Polymorphism in the Bordetella pertussis virulence factors P.69/pertactin
RT and pertussis toxin in The Netherlands: temporal trends and evidence for
RT vaccine-driven evolution.";
RL Infect. Immun. 66:670-675(1998).
RN [2] {ECO:0000313|EMBL:CAA06898.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=287 {ECO:0000313|EMBL:CAA06898.2}, and Al1561
RC {ECO:0000313|EMBL:CAA07477.1};
RX PubMed=10418915; DOI=10.1016/S0264-410X(99)00038-9;
RA Boursaux-Eude C., Thiberge S., Carletti G., Guiso N.;
RT "Intranasal murine model of Bordetella pertussis infection: II. Sequence
RT variation and protection induced by a tricomponent acellular vaccine.";
RL Vaccine 17:2651-2660(1999).
RN [3] {ECO:0000313|EMBL:AAK92093.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=99K45 {ECO:0000313|EMBL:AAK92093.1};
RX PubMed=11500425; DOI=10.1128/IAI.69.9.5520-5528.2001;
RA Fry N.K., Neal S., Harrison T.G., Miller E., Matthews R., George R.C.;
RT "Genotypic variation in the Bordetella pertussis virulence factors
RT pertactin and pertussis toxin in historical and recent clinical isolates in
RT the United Kingdom.";
RL Infect. Immun. 69:5520-5528(2001).
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DR EMBL; AF348485; AAK92093.1; -; Genomic_DNA.
DR EMBL; AJ006156; CAA06898.2; -; Genomic_DNA.
DR EMBL; AJ007362; CAA07477.1; -; Genomic_DNA.
DR EMBL; AJ011093; CAA09475.1; -; Genomic_DNA.
DR RefSeq; WP_050837992.1; NZ_LS483255.1.
DR AlphaFoldDB; O69259; -.
DR PATRIC; fig|520.177.peg.1089; -.
DR GO; GO:0019867; C:outer membrane; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd01343; PL1_Passenger_AT; 1.
DR Gene3D; 2.160.20.20; -; 1.
DR Gene3D; 2.40.128.130; Autotransporter beta-domain; 1.
DR InterPro; IPR005546; Autotransporte_beta.
DR InterPro; IPR036709; Autotransporte_beta_dom_sf.
DR InterPro; IPR012332; Autotransporter_pectin_lyase_C.
DR InterPro; IPR006315; OM_autotransptr_brl_dom.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR InterPro; IPR003992; Pertactin.
DR InterPro; IPR004899; Pertactin_central.
DR InterPro; IPR003991; Pertactin_virulence_factor.
DR NCBIfam; TIGR01414; autotrans_barl; 1.
DR PANTHER; PTHR35037:SF7; AUTOTRANSPORTER PROTEIN-RELATED; 1.
DR PANTHER; PTHR35037; C-TERMINAL REGION OF AIDA-LIKE PROTEIN; 1.
DR Pfam; PF03797; Autotransporter; 1.
DR Pfam; PF03212; Pertactin; 1.
DR PRINTS; PR01482; PERTACTIN.
DR PRINTS; PR01484; PRTACTNFAMLY.
DR SMART; SM00869; Autotransporter; 1.
DR SUPFAM; SSF103515; Autotransporter; 1.
DR SUPFAM; SSF51126; Pectin lyase-like; 1.
DR PROSITE; PS51208; AUTOTRANSPORTER; 1.
PE 4: Predicted;
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..910
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007697113"
FT DOMAIN 642..910
FT /note="Autotransporter"
FT /evidence="ECO:0000259|PROSITE:PS51208"
FT REGION 565..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..600
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 910 AA; 93487 MW; 9035EE1F07A52BC8 CRC64;
MNMSLSRIVK AAPLRRTTLA MALGALGAAP AAHADWNNQS IVKTGERQHG IHIQGSDPGG
VRTASGTTIK VSGRQAQGIL LENPAAELQF RNGSVTSSGQ LSDDGIRRFL GTVTVKAGKL
VADHATLANV GDTWDDDGIA LYVAGEQAQA SIADSTLQGA GGVQIERGAN VTVQRSAIVD
GGLHIGALQS LQPEDLPPSR VVLRDTNVTA VPASGAPAAV SVLGASELTL DGGHITGGRA
AGVAAMQGAV VHLQRATIRR GDAPAGGAVP GGAVPGGFGP GGFGPGGFGP VLDGWYGVDV
SGSSVELAQS IVEAPELGAA IRVGRGARVT VSGGSLSAPH GNVIETGGAR RFAPQAAPLS
ITLQAGAHAQ GKALLYRVLP EPVKLTLTGG ADAQGDIVAT ELPSIPGTSI GPLDVALASQ
ARWTGATRAV DSLSIDNATW VMTDNSNVGA LRLASDGSVD FQQPAEAGRF KVLTVNTLAG
SGLFRMNVFA DLGLSDKLVV MQDASGQHRL WVRNSGSEPA SANTLLLVQT PLGSAATFTL
ANKDGKVDIG TYRYRLAANG NGQWSLVGAK APPAPKPAPQ PGPQPPQPPQ PQPEAPAPQP
PAGRELSAAA NAAVNTGGVG LASTLWYAES NALSKRLGEL RLNPDAGGAW GRGFAQRQQL
DNRAGRRFDQ KVAGFELGAD HAVAVAGGRW HLGGLAGYTR GDRGFTGDGG GHTDSVHVGG
YATYIADSGF YLDATLRASR LENDFKVAGS DGYAVKGKYR THGVGASLEA GRRFTHADGW
FLEPQAELAV FRAGGGAYRA ANGLRVRDEG GSSVLGRLGL EVGKRIELAG GRQVQPYIKA
SVLQEFDGAG TVHTNGIAHR TELRGTRAEL GLGMAAALGR GHSLYASYEY SKGPKLAMPW
TFHAGYRYSW
//
