ID O76960_MANSE Unreviewed; 360 AA.
AC O76960;
DT 01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1998, sequence version 1.
DT 24-JAN-2024, entry version 79.
DE SubName: Full=Nicotinic acetylcholine receptor beta 1 subunit {ECO:0000313|EMBL:CAA07490.1};
DE Flags: Fragment;
OS Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Sphingidae; Sphinginae; Sphingini; Manduca.
OX NCBI_TaxID=7130 {ECO:0000313|EMBL:CAA07490.1};
RN [1] {ECO:0000313|EMBL:CAA07490.1}
RP NUCLEOTIDE SEQUENCE.
RA Eastlake J.L., Tearle A., Lunt G.G., Reynolds S.E., Wonnacott S.,
RA Wolstenholme A.J.;
RT "Nicotinic acetylcholine receptor subunits from Manduca sexta." 27th.
RT Annual Meeting Society for Neuroscience October 1997 Abstract 157.13.";
RL Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AJ007397; CAA07490.1; -; mRNA.
DR AlphaFoldDB; O76960; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 2.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR PANTHER; PTHR18945:SF784; ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 1; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:CAA07490.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 75..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..74
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 85..341
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAA07490.1"
SQ SEQUENCE 360 AA; 41234 MW; AF33FF0BEFFE91FE CRC64;
LDQQTCIMKF GSWTFNGDQV SLALYNNKNF VDLSDYWKSG TWDIIEVPAY LNIYEGNHPT
ETDITFYIII RRKTLFYTVN LILLTVVISF LCVLVFYLPA EAGEKVTLGI SILLALVVFL
LLVSKILPPT SLLLPLIAKY LLFTFIMNTV SILVTVIIIN WNFRGPRTHR MPLWIRSVFL
HYLPAALLMR RPRKTRLRWM MEMPGMVHRL TLQRRTIYQN ILVRLVQNKP KWRQWNCQTC
IIRTAKSNRA AGGEVGALGG LGALGGLGLG GERRESESSD SLLLSPEAAK ATEAVEFIAE
HLRNEDLYIQ TREDWKYVAM VIDRLQLYIF FIVTTAGTVG ILMDAPHLRV LIDQDRIIEL
//
