ID O83116_TREPA Unreviewed; 538 AA.
AC O83116;
DT 01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1998, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=Capsular polysaccharide biosynthesis protein (Cap5D) {ECO:0000313|EMBL:AAC65072.1};
GN OrderedLocusNames=TP_0077 {ECO:0000313|EMBL:AAC65072.1};
OS Treponema pallidum (strain Nichols).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=243276 {ECO:0000313|EMBL:AAC65072.1, ECO:0000313|Proteomes:UP000000811};
RN [1] {ECO:0000313|EMBL:AAC65072.1, ECO:0000313|Proteomes:UP000000811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols {ECO:0000313|EMBL:AAC65072.1,
RC ECO:0000313|Proteomes:UP000000811};
RX PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.,
RA Gwinn M., Hickey E.K., Clayton R., Ketchum K.A., Sodergren E.,
RA Hardham J.M., McLeod M.P., Salzberg S., Peterson J., Khalak H.,
RA Richardson D., Howell J.K., Chidambaram M., Utterback T., McDonald L.,
RA Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S., Hatch B.,
RA Horst K., Roberts K., Watthey L., Weidman J., Smith H.O., Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL Science 281:375-388(1998).
CC -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC {ECO:0000256|ARBA:ARBA00007430}.
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DR EMBL; AE000520; AAC65072.1; -; Genomic_DNA.
DR PIR; D71369; D71369.
DR RefSeq; WP_010881526.1; NC_021490.2.
DR AlphaFoldDB; O83116; -.
DR IntAct; O83116; 3.
DR STRING; 243276.TP_0077; -.
DR EnsemblBacteria; AAC65072; AAC65072; TP_0077.
DR GeneID; 57878617; -.
DR KEGG; tpa:TP_0077; -.
DR PATRIC; fig|243276.9.peg.77; -.
DR eggNOG; COG1086; Bacteria.
DR HOGENOM; CLU_013560_5_2_12; -.
DR OrthoDB; 9803111at2; -.
DR Proteomes; UP000000811; Chromosome.
DR CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003869; Polysac_CapD-like.
DR PANTHER; PTHR43318:SF1; POLYSACCHARIDE BIOSYNTHESIS PROTEIN EPSC-RELATED; 1.
DR PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR Pfam; PF02719; Polysacc_synt_2; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000811}.
FT DOMAIN 188..480
FT /note="Polysaccharide biosynthesis protein CapD-like"
FT /evidence="ECO:0000259|Pfam:PF02719"
SQ SEQUENCE 538 AA; 59305 MW; 650BC5A87D8DEB00 CRC64;
MCGASLGDCV GSCARVNALY VGRDGVGAEN VWGCGRSAVR ESAHRDGIYI VGAGFAGSVL
AREIQTKKVL GTVIAFLDDD PCKIGSNLHG VPVLGPIFEV ARIVRITPHD HALIAIPSIS
IERLRDIYLT LRAAGFTVIK LLPALAQIID GTAHLVQTRE IDPQDLLTRT PVTINLKKSL
AYLCGKRVLV TGAGGSIGSE LACQLLSGDV ERLYLFGHGE NSIYQIDKKI RRLQEEGVGS
RTVIVPVIGD LKDAAYVRYL IEQLRCDAVF HAAAYKHVPM MELNPVSVIE NNVFGTKFLL
DACIACRVKR FVLLSTDKAV DPVSIYGVSK MLNEKNVLYA AERVRDFGHD AAYMFVRFGN
VLGSRGSIMP LFIEQIKKGG PVTVTDPAMT RFFMTIPEAC SLVLQVGGVG VNGASYLLDM
GEPVSIMETA QQLIRYFGYE PDRDIPIHVV GLRPGERLSE PLVSKDERIE PTVYPKVLRL
REREPLDFAH LERLWDQLYP YCFPSGEKVR YRHKEGLVRV LCDSCATLKQ RYMPNSEA
//
