ID O83741_TREPA Unreviewed; 652 AA.
AC O83741;
DT 01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1998, sequence version 1.
DT 27-MAR-2024, entry version 125.
DE SubName: Full=Penicillin-binding protein (Pbp-3) {ECO:0000313|EMBL:AAC65726.1};
GN OrderedLocusNames=TP_0760 {ECO:0000313|EMBL:AAC65726.1};
OS Treponema pallidum (strain Nichols).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=243276 {ECO:0000313|EMBL:AAC65726.1, ECO:0000313|Proteomes:UP000000811};
RN [1] {ECO:0000313|EMBL:AAC65726.1, ECO:0000313|Proteomes:UP000000811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols {ECO:0000313|EMBL:AAC65726.1,
RC ECO:0000313|Proteomes:UP000000811};
RX PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.,
RA Gwinn M., Hickey E.K., Clayton R., Ketchum K.A., Sodergren E.,
RA Hardham J.M., McLeod M.P., Salzberg S., Peterson J., Khalak H.,
RA Richardson D., Howell J.K., Chidambaram M., Utterback T., McDonald L.,
RA Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S., Hatch B.,
RA Horst K., Roberts K., Watthey L., Weidman J., Smith H.O., Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL Science 281:375-388(1998).
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DR EMBL; AE000520; AAC65726.1; -; Genomic_DNA.
DR PIR; C71285; C71285.
DR RefSeq; WP_010882205.1; NC_021490.2.
DR AlphaFoldDB; O83741; -.
DR SMR; O83741; -.
DR IntAct; O83741; 2.
DR STRING; 243276.TP_0760; -.
DR EnsemblBacteria; AAC65726; AAC65726; TP_0760.
DR GeneID; 57879282; -.
DR KEGG; tpa:TP_0760; -.
DR PATRIC; fig|243276.9.peg.747; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_6_0_12; -.
DR OrthoDB; 9770103at2; -.
DR Proteomes; UP000000811; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR CDD; cd06575; PASTA_Pbp2x-like_2; 1.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03793; PASTA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SMART; SM00740; PASTA; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR SUPFAM; SSF54184; Penicillin-binding protein 2x (pbp-2x), c-terminal domain; 1.
DR PROSITE; PS51178; PASTA; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000811};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 39..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 592..652
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
SQ SEQUENCE 652 AA; 71518 MW; 2BD943389A7F78AE CRC64;
MSAPTSFRVH PWDASLPCTG VHPSWEEARP AVNITRSRVA VFISSLTAVL LLLTVQCARY
MLMRGNETKE LNTLTERGAI LDRNGRFLAV GTTVYNLSVN KNLVSDPRTA AHVLAQVLDL
SEQDIEEKFR TARAHFFYLK KKMSETEKNL VAHALKEHSL KGFRLEAVRN RIYPESSLAS
TVIGYVGDDG RGLSGIEYTL QDVLSPAPYH TGYTGKGHTV TLSIDRTIQY MMEKIADTTL
RRTQAEGLMF LAVEAKTGQI LSYVSKPSAN LSHFSQSTPA ERFDRPALFI YEPGSVFKIF
SIAALLELGV TYTHDTLHCD GSFSFTSPFL KPGQKGHLIR CLRPHGTISA EDIIRLSCND
GMAQIAERAD NHSFEQLLRA FGFGAKTEIE LPGETVGLFS PSERWSHRSK HTIAIGQEIG
VSALQVVAAA TALANEGVPL GLSLLHEVTT AEGTVVYRHK KKPKTRVISA VNAQKVLRYM
RTAAELGTGK KALVDGVPIA VKTGTAQMAH RNGRGYSDTD YLASCIGLFP AHDPEIILYI
AIIRPIGQAY GELIAAPVIS QAANEIIDYR GMVRANAPLI QHSGLIHTSE RTPPRLGTHM
PDLTGQPKRL LLDIAKRTDV HLVLTGEGYV YEQHPPAGTP LTKGMTIELK LK
//
