ID O86304_STRAM Unreviewed; 417 AA.
AC O86304;
DT 01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1998, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Macrolide glycosyl transferase {ECO:0000313|EMBL:CAA11707.1};
GN Name=mgtA {ECO:0000313|EMBL:CAA11707.1};
OS Streptomyces ambofaciens.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1889 {ECO:0000313|EMBL:CAA11707.1};
RN [1] {ECO:0000313|EMBL:CAA11707.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC23877 {ECO:0000313|EMBL:CAA11707.1};
RA Pernodet J.L., Gourmelen A., Blondelet-Rouault M.H., Cundliffe E.;
RT "Dispensable ribosomal resistance tp spiramycin conferred by srmA in the
RT spiramycin producer Streptomyces ambofaciens.";
RL Microbiology 145:2355-2364(1999).
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000256|ARBA:ARBA00009995}.
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DR EMBL; AJ223970; CAA11707.1; -; Genomic_DNA.
DR AlphaFoldDB; O86304; -.
DR CAZy; GT1; Glycosyltransferase Family 1.
DR KEGG; ag:CAA11707; -.
DR OMA; MFSIAAH; -.
DR GO; GO:0016758; F:hexosyltransferase activity; IEA:InterPro.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR010610; EryCIII-like_C.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR InterPro; IPR006326; UDPGT_MGT-like.
DR NCBIfam; TIGR01426; MGT; 1.
DR PANTHER; PTHR48050; STEROL 3-BETA-GLUCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR48050:SF13; UDP-GLUCURONOSYLTRANSFERASE; 1.
DR Pfam; PF06722; EryCIII-like_C; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS00375; UDPGT; 1.
PE 3: Inferred from homology;
KW Transferase {ECO:0000313|EMBL:CAA11707.1}.
FT DOMAIN 280..396
FT /note="Erythromycin biosynthesis protein CIII-like C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF06722"
SQ SEQUENCE 417 AA; 45427 MW; B693EF18F6FCA5FD CRC64;
MRRGDLHETY RLDYAPHMHD PAHIAMFSIA AHGHVNPSLE VIRELVARGH RVTYAIPPLF
AEKVAETGAE PKLWNSTLPG PDADPDAWGT TPLDNVEPFL DDAIQALPQL IAAYEGDEPD
LVLHDITSYP ARVLAHRWGV PAVSLSPNLV AWEGYEEEVG RPTWEEPLKT ERGRAYDARF
RGWLKENGIT EDPDPFVGRP DRSLVLIPKA LQPHADRVDE KTHTFVGACQ GDRAAEGDWR
RPEGAEKVVL VSLGSSFTKR PAFYRACVEA FGALPGWHVV LQVGRHVDPA ELGDVPENVE
VRSWVPQLAI LKQADLFVTH AGAGGSQEGL ATATPIVAVP QAVDQFGNAD MLQGLGVGRH
LPTEEATAEA LRAAGLALVE DPEVARRLKE IQAGMAREGG TRRAADLIEA ELAAART
//
