ID   O93635_THESU            Unreviewed;       891 AA.
AC   O93635;
DT   01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT   01-MAY-1999, sequence version 1.
DT   27-MAR-2024, entry version 79.
DE   SubName: Full=Stetterlysin {ECO:0000313|EMBL:AAC68832.1};
DE   Flags: Fragment;
GN   Name=plsT {ECO:0000313|EMBL:AAC68832.1};
OS   Thermococcus stetteri.
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=49900 {ECO:0000313|EMBL:AAC68832.1};
RN   [1] {ECO:0000313|EMBL:AAC68832.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9415440; DOI=10.1093/protein/10.8.905;
RA   Voorhorst W.G., Warner A., de Vos W.M., Siezen R.J.;
RT   "Homology modelling of two subtilisin-like proteases from the
RT   hyperthermophilic archaea Pyrococcus furiosus and Thermococcus stetteri.";
RL   Protein Eng. 10:905-914(1997).
RN   [2] {ECO:0000313|EMBL:AAC68832.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9070434; DOI=10.1002/pro.5560060301;
RA   Siezen R.J., Leunissen J.A.;
RT   "Subtilases: the superfamily of subtilisin-like serine proteases.";
RL   Protein Sci. 6:501-523(1997).
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC       ECO:0000256|RuleBase:RU003355}.
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DR   EMBL; AF015225; AAC68832.1; -; Genomic_DNA.
DR   AlphaFoldDB; O93635; -.
DR   MEROPS; S08.106; -.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 2.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR   PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}.
FT   DOMAIN          180..637
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   ACT_SITE        189
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        391
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        587
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   NON_TER         891
FT                   /evidence="ECO:0000313|EMBL:AAC68832.1"
SQ   SEQUENCE   891 AA;  97754 MW;  BC50B70A489FA219 CRC64;
     MNRRVLSLLI VAVMLLSAIP AAVSVPAVTA TPVQPTDIPQ QVAVEKPSNF IPGEVLQKEI
     QKVLEISGKT VRLIISPEKD RAMEVYETLK RLGKIDPISK PDLQFIVVEM PVSNVEKLAE
     IPGILHVWKD EMVKLQEPVS PEAGMDGVTP AVQDPKLPDM FMSVYKIHAY DTWINYGVLG
     DNVTVAVLDT GIDVGHPFLQ VTLDGRPKIV DIYDASDEGI AQIYYATNVT ENGTITVNMT
     VPVYWGFYAM YYGHEQITDY TMGTYYVGGI NGSEYYLGLL PERYFDLNNL TSRPDDLMGD
     LNDVYPVLIV NQSGNFVAYI DFNLNNDFTD DQPIGLFTET GDYFQTPDTL VDIALAKVHI
     GDMSNPDNYL YTVPTEDGIG YAMFMWDAQG HGTHVSGTLA GVGLPTDPVF NGTYGVAPNA
     QLMEVKVLPG EFGFGATSWI INGMIYAASN GADVISMSLG GGGEINDGIE SPENFYVNLL
     TDWFGVTFAI AAGNEGPTTN TVHAPGDSDL VITVGAFRSS LRWQIFYGVD GVADTVASFS
     SRGPRMDGLL DPDVIAPGEM IFSSLPLWYT VTNNDSYNYY GIWDGTSMAT PHVSGAVALM
     ISYAKQHNLT YDPIMIKRAL ELSAKPVNGT LIDQGFGLIQ VDKAIEELEK LSQEPTTYIF
     AGTTYTSFKN PIEEPLIPIS PAYVDSNGYF QNVFGFPYLY RGVYIRNEYP GSVPIYFYPM
     KYVEDYGLNY TTSEKTYKIS TNVDWIIPNT NAVVAGNNTI GEFSINIDYS KLQKSGTYVG
     LVYIDDPDTS YIDGYIAVTV DIPVNFNGES HAALSDTALP GEAKHYFVKV PRGTKELRVT
     LRVPLDESGT PMGRTTLMIA RPEGAVVAEY VPGYGFVGPG LPEYTWVIED P
//