ID OMPA_CITFR Reviewed; 238 AA.
AC P24016;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-1992, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE RecName: Full=Outer membrane protein A {ECO:0000250|UniProtKB:P0A910};
DE AltName: Full=Outer membrane porin A {ECO:0000250|UniProtKB:P0A910};
DE AltName: Full=Outer membrane protein 3A {ECO:0000303|PubMed:1955870};
DE Flags: Fragment;
GN Name=ompA {ECO:0000250|UniProtKB:P0A910};
OS Citrobacter freundii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Citrobacter; Citrobacter freundii complex.
OX NCBI_TaxID=546;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=OS60;
RX PubMed=1955870; DOI=10.1099/00221287-137-8-1911;
RA Lawrence J.G., Ochman H., Hartl D.L.;
RT "Molecular and evolutionary relationships among enteric bacteria.";
RL J. Gen. Microbiol. 137:1911-1921(1991).
CC -!- FUNCTION: With TolR probably plays a role in maintaining the position
CC of the peptidoglycan cell wall in the periplasm. Acts as a porin with
CC low permeability that allows slow penetration of small solutes; an
CC internal gate slows down solute passage.
CC {ECO:0000250|UniProtKB:P0A910}.
CC -!- SUBUNIT: Monomer and homodimer. {ECO:0000250|UniProtKB:P0A910}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000250|UniProtKB:P0A910}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P0A910}.
CC -!- DOMAIN: The extracellular loops are most variable in sequence, and in
CC some bacteria confer sensitivity to phage and/or colicins.
CC {ECO:0000250|UniProtKB:P0A910}.
CC -!- SIMILARITY: Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
CC OmpA family. {ECO:0000305}.
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DR EMBL; M63354; AAA23095.1; -; Genomic_DNA.
DR PIR; I40703; I40703.
DR AlphaFoldDB; P24016; -.
DR SMR; P24016; -.
DR STRING; 1333848.CFNIH1_14820; -.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR CDD; cd07185; OmpA_C-like; 1.
DR Gene3D; 2.40.160.20; -; 1.
DR Gene3D; 3.30.1330.60; OmpA-like domain; 1.
DR InterPro; IPR011250; OMP/PagP_b-brl.
DR InterPro; IPR006664; OMP_bac.
DR InterPro; IPR002368; OmpA.
DR InterPro; IPR006665; OmpA-like.
DR InterPro; IPR006690; OMPA-like_CS.
DR InterPro; IPR036737; OmpA-like_sf.
DR InterPro; IPR000498; OmpA-like_TM_dom.
DR PANTHER; PTHR30329:SF23; LIPOPROTEIN YIAD-RELATED; 1.
DR PANTHER; PTHR30329; STATOR ELEMENT OF FLAGELLAR MOTOR COMPLEX; 1.
DR Pfam; PF00691; OmpA; 1.
DR Pfam; PF01389; OmpA_membrane; 1.
DR PRINTS; PR01021; OMPADOMAIN.
DR PRINTS; PR01022; OUTRMMBRANEA.
DR SUPFAM; SSF56925; OMPA-like; 1.
DR SUPFAM; SSF103088; OmpA-like; 1.
DR PROSITE; PS01068; OMPA_1; 1.
DR PROSITE; PS51123; OMPA_2; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Disulfide bond; Ion transport; Membrane; Porin;
KW Repeat; Transmembrane; Transmembrane beta strand; Transport.
FT CHAIN <1..>238
FT /note="Outer membrane protein A"
FT /id="PRO_0000196252"
FT TRANSMEM <1..8
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0A910"
FT TRANSMEM 13..21
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0A910"
FT TRANSMEM 43..52
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0A910"
FT TRANSMEM 57..64
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0A910"
FT TRANSMEM 83..91
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0A910"
FT REPEAT 104..105
FT /note="1"
FT REPEAT 106..107
FT /note="2"
FT REPEAT 108..109
FT /note="3"
FT DOMAIN 111..>238
FT /note="OmpA-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00473"
FT REGION 104..109
FT /note="3 X 2 AA tandem repeats of A-P"
FT SITE 60
FT /note="Part of salt bridge gating mechanism"
FT /evidence="ECO:0000250|UniProtKB:P0A910"
FT DISULFID 212..224
FT /evidence="ECO:0000250|UniProtKB:P0A910"
FT NON_TER 1
FT NON_TER 238
SQ SEQUENCE 238 AA; 25664 MW; 66EA136D73A3F286 CRC64;
LTAKLGYPIT DDLDIYTRLG GMVWRADAKN NEGFKDHDTG VSPVFAGGVE YAITPEIATR
LEYQWTNNIG DANTVGGRPD NGLLSVGVSY RFGQQEEAAP VVVAPAPAPE VQTKHFTLKS
DVLFNFNKAT LKPEGQQALD QMYSQLSNLD PKDGSVVVLG FTDRIGSDAY NQGLSEKRAQ
SVVDYLISKG IPSDKISARG MGESNPVTGN TCDNVKARAA LIDCLAPDRR VEIEVKGI
//
