ID OMPA_RICCN Reviewed; 2021 AA.
AC Q52657; P95591; P95592; P95593; P95594; Q52667; Q52668; Q52669; Q52670;
AC Q52674;
DT 11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2001, sequence version 2.
DT 27-MAR-2024, entry version 130.
DE RecName: Full=Outer membrane protein A;
DE AltName: Full=190 kDa antigen;
DE AltName: Full=Cell surface antigen;
DE AltName: Full=rOmp A;
DE Short=rOmpA;
DE Contains:
DE RecName: Full=120 kDa surface-exposed protein;
DE AltName: Full=120 kDa outer membrane protein OmpA;
DE Contains:
DE RecName: Full=32 kDa beta peptide;
DE Flags: Precursor;
GN Name=ompA; OrderedLocusNames=RC1273;
OS Rickettsia conorii (strain ATCC VR-613 / Malish 7).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX NCBI_TaxID=272944;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC VR-613 / Malish 7;
RX PubMed=8125327; DOI=10.1016/0378-1119(94)90740-4;
RA Crocquet-Valdes P.A., Weiss K., Walker D.H.;
RT "Sequence analysis of the 190-kDa antigen-encoding gene of Rickettsia
RT conorii (Malish 7 strain).";
RL Gene 140:115-119(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-613 / Malish 7;
RX PubMed=11557893; DOI=10.1126/science.1061471;
RA Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.;
RT "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL Science 293:2093-2098(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-204.
RC STRAIN=ATCC VR-613 / Malish 7, Indian tick typhus, M1, and Moroccan;
RX PubMed=8862558; DOI=10.1128/jcm.34.9.2058-2065.1996;
RA Roux V., Fournier P.E., Raoult D.;
RT "Differentiation of spotted fever group rickettsiae by sequencing and
RT analysis of restriction fragment length polymorphism of PCR-amplified DNA
RT of the gene encoding the protein rOmpA.";
RL J. Clin. Microbiol. 34:2058-2065(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 953-2012.
RC STRAIN=ATCC VR-613 / Malish 7, Indian tick typhus, M1, and Moroccan;
RA Raoult D., Fournier P.E., Roux V.;
RT "Phylogenetic analysis of spotted fever group rickettsiae by study of the
RT outer surface protein rOmpA.";
RL Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Elicits protective immunity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [Outer membrane protein A]: Periplasm
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [120 kDa surface-exposed protein]: Secreted
CC {ECO:0000250}. Cell surface {ECO:0000250}. Note=Surface exposed. This
CC bacterium is covered by a S-layer with hexagonal symmetry.
CC -!- SUBCELLULAR LOCATION: [32 kDa beta peptide]: Cell outer membrane
CC {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=The
CC cleaved C-terminal fragment (autotransporter domain) is localized in
CC the outer membrane.
CC -!- PTM: Glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the rickettsiae OmpA/OmpB family. {ECO:0000305}.
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DR EMBL; U01028; AAA17405.1; -; Unassigned_DNA.
DR EMBL; AE006914; AAL03811.1; -; Genomic_DNA.
DR EMBL; U43794; AAB49549.1; -; Genomic_DNA.
DR EMBL; U43798; AAB49550.1; -; Genomic_DNA.
DR EMBL; U43806; AAB49551.1; -; Genomic_DNA.
DR EMBL; U45244; AAB49566.1; -; Genomic_DNA.
DR EMBL; U46918; AAA86663.1; -; Genomic_DNA.
DR EMBL; U83440; AAC35176.1; -; Genomic_DNA.
DR EMBL; U83443; AAC35179.1; -; Genomic_DNA.
DR EMBL; U83448; AAC35184.1; -; Genomic_DNA.
DR EMBL; U83453; AAC35189.1; -; Genomic_DNA.
DR PIR; A97859; A97859.
DR RefSeq; WP_010977835.1; NC_003103.1.
DR AlphaFoldDB; Q52657; -.
DR GeneID; 928425; -.
DR KEGG; rco:RC1273; -.
DR PATRIC; fig|272944.4.peg.1464; -.
DR HOGENOM; CLU_000413_0_0_5; -.
DR Proteomes; UP000000816; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR Gene3D; 2.40.128.130; Autotransporter beta-domain; 1.
DR InterPro; IPR005546; Autotransporte_beta.
DR InterPro; IPR036709; Autotransporte_beta_dom_sf.
DR InterPro; IPR006315; OM_autotransptr_brl_dom.
DR NCBIfam; TIGR01414; autotrans_barl; 1.
DR Pfam; PF03797; Autotransporter; 1.
DR SMART; SM00869; Autotransporter; 1.
DR SUPFAM; SSF103515; Autotransporter; 1.
DR PROSITE; PS51208; AUTOTRANSPORTER; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Glycoprotein; Membrane; Periplasm; Repeat; Secreted;
KW Signal; Transmembrane; Transmembrane beta strand.
FT SIGNAL 1..38
FT /evidence="ECO:0000255"
FT CHAIN 39..2021
FT /note="Outer membrane protein A"
FT /id="PRO_0000032646"
FT CHAIN 39..?
FT /note="120 kDa surface-exposed protein"
FT /id="PRO_0000387575"
FT CHAIN ?..2021
FT /note="32 kDa beta peptide"
FT /id="PRO_0000387576"
FT DOMAIN 1734..2021
FT /note="Autotransporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00556"
FT VARIANT 60
FT /note="N -> NN (in strain: Indian tick typhus)"
FT VARIANT 76
FT /note="R -> H (in strain: Indian tick typhus)"
FT VARIANT 86..137
FT /note="Missing (in strain: M1)"
FT VARIANT 126..133
FT /note="Missing (in strain: Moroccan)"
FT VARIANT 953..954
FT /note="VT -> II (in strain: Indian tick typhus)"
FT VARIANT 1245
FT /note="D -> A (in strain: Indian tick typhus, M1 and
FT Moroccan)"
FT VARIANT 1308
FT /note="N -> H (in strain: Moroccan)"
FT VARIANT 1877
FT /note="M -> I (in strain: Indian tick typhus)"
FT CONFLICT 10
FT /note="Q -> K (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 92
FT /note="I -> V (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 126
FT /note="V -> I (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 137
FT /note="T -> N (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 157
FT /note="G -> D (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 368..369
FT /note="IS -> VN (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 374..388
FT /note="KATLGGAIIKATTTK -> LLQVQGGVVKANTIN (in Ref. 1;
FT AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 640
FT /note="N -> D (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 669
FT /note="V -> I (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 793
FT /note="N -> D (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 803..804
FT /note="VN -> IS (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 809..823
FT /note="LLRVQGGVVKSNTIN -> KATLGGAIIKATTTK (in Ref. 1;
FT AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 898
FT /note="D -> Y (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 908
FT /note="P -> N (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 985
FT /note="N -> K (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 1009
FT /note="L -> S (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 1013
FT /note="Y -> S (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 1182
FT /note="K -> Q (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 1314
FT /note="N -> Y (in Ref. 4; AAC35189)"
FT /evidence="ECO:0000305"
FT CONFLICT 1451
FT /note="H -> N (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 1624
FT /note="G -> D (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 1628
FT /note="E -> G (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 1872
FT /note="A -> V (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 1875
FT /note="T -> P (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 1878..1879
FT /note="MS -> LP (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 1936
FT /note="E -> A (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 1965..1970
FT /note="MTAPLP -> ITPPLS (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
FT CONFLICT 1997
FT /note="G -> R (in Ref. 1; AAA17405)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2021 AA; 203330 MW; 327FC42D7CB24668 CRC64;
MANISPKLFQ KAIQQGLKAA LFTTSTAAIM LSSSGALGIA VSGVIATNNN AAFSDNVGNN
WNEITAAGVA NGTPARGPQN NWAFTYGGDY TITADVADHI ITAINVADTT PIGLNIAQNT
VVGSIVTGGN LLPVTITAGK SLTLNGNNAD AANHGFGAPA DNYTGLGNIA LGGANAALII
QSAAPAKITL AGNINGGGII TVKTDAAING TIGNTNALAT VNVGAGIATL EGAIIKATTT
KLTNAASVLT LTNVNAVLTG AIDNTTGVDN VGVLNLNGAL SQVTGNIGNT NALATISVGA
GKATLGGAVI KATTTKLTDN ASAVTFTNPV VVTGAIDNTG NANNGIVTFT GDSTVTGNIG
NTNALATISV GAGKATLGGA IIKATTTKLT DNASAVTFTN PVVVTGAIDN TGNANNGIVT
FTGDSTVTGN IGNTNALATI SVGAGKATLG GAIIKATTTK LTDNASAVTF TNPVVVTGAI
DNTGNANNGI VTFTGDSTVT GNIGNTNALA TISVGAGKAT LGGAIIKATT TKLTDNASAV
TFTNPVVVTG AIDNTGNANN GIVTFTGDST VTGNIGNTNA LATISVGAGK ATLGGAIIKA
TTTKLTDNAS AVTFTNPVVV TGAIDNTGNA NNGIVTFTGN STVTGNIGNT NALATVNVGA
GIATLEGAVI KATTTKLTNA ASVLTLTNVN AVLTGAIDNT TGVDNVGVLN LNGALSQVTG
NIGNTNALAT ISVGAGKATL GGAVIKATTT KLTDNASAVT FTNPVVVTGA IDNTGNANNG
IATFTGDSTV TGNIGNTNAL ATVNVGAGLL RVQGGVVKSN TINLTDNASA VTFTNPVVVT
GAIDNTGNAN NGIVTFTGDS TVTGNIGNTN ALATISVGAG KATLGGAIIK ATTTKLTDNA
SAVTFTNPVV VTGAIDNTGN ANNGIVTFTG DSTVTGNIGN TNALATVNVG AGVTLQAGGS
LDANNIDFGA RSTLEFNGPL DGGGNAIPYY FKGAIANGNN AILNVNTKLL TAYHLTIGTV
AEINIGAGNL FAIDASAGDV TILNAQDIHF RALDSALVLS NLTGVGVNNI LLAADLVAPG
VDEGTVVFDG GVNGLNIGSN VAGAARNIGD VGGNKFNTLL IYNAVTITDD VNLEGIQNVL
INNNADFTSS TAFNAGTIQI NDATYTIDAN NGNLNIPAGN IKFAHADAQL ILQNSSGNDR
TITLGANIDP DNDDEGIVIL NSVTAGKKLT IAGGKTFGGA HKLQDIVFKG EGDFGTAGTT
FNTTNIVLDI TGQLELGATT ANVVLFKDAV QLTQTGNIGG FLDFNAKNGT VTLNNNVNVA
GTVKNTGGTN NGTLIVLGAS NLNRVNGIAM LKVGAGNVTI AKGGNVKIGE IQGTGTNTLT
LPAHFKLTGS INKTGGQALK LNFMNGGSVS GVVGTAANSV GDITTAGATS FASSVNAKGT
ATLGGTTSFA HTFTNTGAVT LAKGSITSFA KNVTATSFVA NSATINFGNS LAFNSNITGS
GTTLTLGANQ VTYTGTGSFT DTLTLNTTFD GAAKSGGNIL IKSGSTLDLS GVSNLALVVT
ATNFDMNNIS PDTKYTVISA ETAGGLKPTP KENVKITINN DNRFVDFTFD ASTLTLFAED
IAAGVIDEDF APGGPLANIP NAANIKKSLE LMEDAPNGSD ARQAFNNFGL MTPLQEADAT
THLMQDVVKP SDTIAAVNNQ VVASNISSNI TALNARMDKV QAGNKGPVSS GDEDMDAKFG
AWISPFVGNA TQKMCNSISG YKSDTTGGTI GFDGFVSDDL VLGLAYTRAD TDIKLKNNKT
GDKNKVESNI YSLYGLYSVP YENLFVEAIA SYSDNKIRSK SRRVIATTLE TVGYQTANGK
YKSESYTGQL MAGYTYMMSE NINLTPLAGL RYSTIKDKSY KETGTTYQNL TVKGKNYNTF
DGLLGAKVSS NINVNEIVLT PELYAMVDYA FKNKVSAIDA RLQGMTAPLP TNSFKQSKTS
FDVGVGVTAK HKMMEYGINY DTNIGSKYFA QQGSVKVRVN F
//
