ID OMPA_RICRI Reviewed; 2249 AA.
AC P15921;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 13-SEP-2023, entry version 99.
DE RecName: Full=Outer membrane protein A;
DE AltName: Full=190 kDa antigen;
DE AltName: Full=Cell surface antigen;
DE AltName: Full=rOmp A;
DE Short=rOmpA;
DE Contains:
DE RecName: Full=120 kDa surface-exposed protein;
DE AltName: Full=120 kDa outer membrane protein OmpA;
DE Contains:
DE RecName: Full=32 kDa beta peptide;
DE Flags: Precursor;
GN Name=ompA;
OS Rickettsia rickettsii.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX NCBI_TaxID=783;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=R;
RX PubMed=2117568; DOI=10.1128/iai.58.9.2760-2769.1990;
RA Anderson B.E., McDonald G.A., Jones D.C., Regnery R.L.;
RT "A protective protein antigen of Rickettsia rickettsii has tandemly
RT repeated, near-identical sequences.";
RL Infect. Immun. 58:2760-2769(1990).
CC -!- FUNCTION: Elicits protective immunity.
CC -!- SUBCELLULAR LOCATION: [Outer membrane protein A]: Periplasm
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [120 kDa surface-exposed protein]: Secreted
CC {ECO:0000250}. Cell surface {ECO:0000250}. Note=Surface exposed. This
CC bacterium is covered by a S-layer with hexagonal symmetry.
CC -!- SUBCELLULAR LOCATION: [32 kDa beta peptide]: Cell outer membrane
CC {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=The
CC cleaved C-terminal fragment (autotransporter domain) is localized in
CC the outer membrane.
CC -!- PTM: Glycosylated. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the rickettsiae OmpA/OmpB family. {ECO:0000305}.
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DR EMBL; M31227; AAA26380.1; -; Genomic_DNA.
DR PIR; A41477; A41477.
DR AlphaFoldDB; P15921; -.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR Gene3D; 2.40.128.130; Autotransporter beta-domain; 1.
DR InterPro; IPR005546; Autotransporte_beta.
DR InterPro; IPR036709; Autotransporte_beta_dom_sf.
DR InterPro; IPR006315; OM_autotransptr_brl_dom.
DR NCBIfam; TIGR01414; autotrans_barl; 1.
DR Pfam; PF03797; Autotransporter; 1.
DR SMART; SM00869; Autotransporter; 1.
DR SUPFAM; SSF103515; Autotransporter; 1.
DR PROSITE; PS51208; AUTOTRANSPORTER; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Glycoprotein; Membrane; Periplasm; Repeat; Secreted;
KW Signal; Transmembrane; Transmembrane beta strand.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..2249
FT /note="Outer membrane protein A"
FT /id="PRO_0000032647"
FT CHAIN 29..?
FT /note="120 kDa surface-exposed protein"
FT /id="PRO_0000387577"
FT CHAIN ?..2249
FT /note="32 kDa beta peptide"
FT /id="PRO_0000387578"
FT REPEAT 212..286
FT /note="Type I 1"
FT REPEAT 287..358
FT /note="Type II 1"
FT REPEAT 359..430
FT /note="Type II 2"
FT REPEAT 431..505
FT /note="Type I 2"
FT REPEAT 506..577
FT /note="Type II 3"
FT REPEAT 578..652
FT /note="Type I 3"
FT REPEAT 653..724
FT /note="Type II 4"
FT REPEAT 725..799
FT /note="Type I 4"
FT REPEAT 800..874
FT /note="Type I 5"
FT REPEAT 875..949
FT /note="Type I 6"
FT REPEAT 950..1021
FT /note="Type II 5"
FT REPEAT 1022..1093
FT /note="Type II 6"
FT REPEAT 1094..1165
FT /note="Type II 7"
FT REPEAT 1166..1180
FT /note="Type I 7; truncated"
FT DOMAIN 1962..2249
FT /note="Autotransporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00556"
FT REGION 212..1180
FT /note="14 X approximate tandem repeats"
SQ SEQUENCE 2249 AA; 224333 MW; A9D6646C089DF087 CRC64;
MANISPKLFK KAIQQGLKAA LFTTSTAAIM LSSSGALGVA TGVIATNNNA AFSNNVGNNN
WNEITAAGVA NGTPAGGPQN NWAFTYGGDY TVTADAADRI IKAINVAGTT PVGLNITQNT
VVGSIITKGN LLPVTLNAGK SLTLNGNNAV AANHGFDAPA DNYTGLGNIA LGGANAALII
QSAAPSKITL AGNIDGGGII TVKTDAAING TIGNTNALAT VNVGAGTATL GGAVIKATTT
KLTNAASVLT LTNANAVLTG AIDNTTGGDN VGVLNLNGAL SQVTGDIGNT NSLATISVGA
GTATLGGAVI KATTTKLTDA ASAVKFTNPV VVTGAIDNTG NANNGIVTFT GNSTVTGNVG
NTNALATVNV GAGLLQVQGG VVKANTINLT DNASAVTFTN PVVVTGAIDN TGNANNGIVT
FTGNSTVTGD IGNTNALATV NVGAGTATLG GAVIKATTTK LTNAASVLTL TNANAVLTGA
IDNTTGGDNV GVLNLNGALS QVTGNIGNTN SLATISVGAG TATLGGAVIK ATTTKLTDAA
SAVKFTNPVV VTGAIDNTGN ANNGIVTFTG NSTVTGDIGN TNSLATISVG AGTATLGGAV
IKATTTKLTN AASVLTLTNA NAVLTGAIDN TTGGDNVGVL NLNGALSQVT GDIGNTNSLA
TISVGAGTAT LGGAVIKATT TKITNAVSAV KFTNPVVVTG AIDSTGNANN GIVTFTGNST
VTGDIGNTNA LATVNVGAGT ATLGGAVIKA TTTKLTNAAS VLTLTNANAV LTGAIDNTTG
GDNVGVLNLN GALSQVTGDI GNTNSLATIS VGAGTATLGG AVIKATTTKL TNAASVLTLT
NANAVLTGAV DNTTGGDNVG VLNLNGALSQ VTGDIGNTNS LATISVGAGT ATLGGAVIKA
TTTKLTNAAS VLTLTNANAV LTGAIDNTTG GDNVGVLNLN GALSQVTGDI GNTNSLATIS
VGAGTATLGG AVIKATTTKL TDAASAVKFT NPVVVTGAID NTGNANNGIV TFTGNSTVTG
NVGNTNALAT VNVGAGLLQV QGGVVKANTI NLTDNASAVT FTNPVVVTGA IDNTGNANNG
IVTFTGNSTV TGNVGNTNAL ATVNVGAGLL QVQGGVVKAN TINLTDNASA VTFTNPVVVT
GAIDNTGNAN NGIVTFTGNS TVTGDIGNTN ALATVNVGAG ITLQAGGSLA ANNIDFGARS
TLEFNGPLDG GGKAIPYYFK GAIANGNNAI LNVNTKLLTA SHLTIGTVAE INIGAGNLFT
IDASVGDVTI LNAQNINFRA RDSVLVLSNL TGVGVNNILL AADLVAPGAD EGTVVFNGGV
NGLNVGSNVA GTARNIGDGG GNKFNTLLIY NAVTITDDVN LEGIQNVLIN KNADFTSSTA
FNAGAIQIND ATYTIDANNG NLNIPAGNIQ FAHADAQLVL QNSSGNDRTI TLGANIDPDN
DDEGIVILNS VTAGKKLTIA GGKTFGGAHK LQTILFKGAG DCSTAGTTFN TTNIVLDITG
QLELGATTAN VVLFNDAVQL TQTGNIGGFL DFNAKNGMVT LNNNVNVAGA VQNTGGTNNG
TLIVLGASNL NRVNGIAMLK VGAGNVTIAK GGKVKIGEIQ GTGTNTLTLP AHFNLTGSIN
KTGGQALKLN FMNGGSVSGV VGTAANSVGD ITTAGATSFA SSVNAKGTAT LGGTTSFANT
FTNTGAVTLA KGSITSFAKN VTATSFVANS ATINFSNSLA FNSNITGGGT TLTLGANQVT
YTGTGSFTDT LTLNTTFDGA AKSGGNILIK SGSTLDLSGV STLALVVTAT NFDMNNISPD
TKYTVISAET AGGLKPTSKE NVKITINNDN RFVDFTFDAS TLTLFAEDIA ADVIDGDFAP
GGPLANIPNA ANIKKSLELM EDAPNGSDAR QAFNNFGLMT PLQEADATTH LIQDVVKPSD
TIAAVNNQVV ASNISSNITA LNARMDKVQS GNKGPVSSGD EDMDAKFGAW ISPFVGNATQ
KMCNSISGYK SDTTGGTIGF DGFVSDDLAL GLAYTRADTD IKLKNNKTGD KNKVESNIYS
LYGLYNVPYE NLFVEAIASY SDNKIRSKSR RVIATTLETV GYQTANGKYK SESYTGQLMA
GYTYMMPENI NLTPLAGLRY STIKDKGYKE TGTTYQNLTV KGKNYNTFDG LLGAKVSSNI
NVNEIVLTPE LYAMVDYAFK NKVSAIDARL QGMTAPLPTN SFKQSKTSFD VGVGVTAKHK
MMEYRINYDT NIGSKYFAQQ GSVKVRVNF
//
