ID OPCM_PANTR Reviewed; 345 AA.
AC Q5IS61;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE RecName: Full=Opioid-binding protein/cell adhesion molecule;
DE Short=OBCAM;
DE Short=OPCML;
DE Short=Opioid-binding cell adhesion molecule;
DE Flags: Precursor;
GN Name=OPCML; Synonyms=OBCAM;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15620360; DOI=10.1016/j.cell.2004.11.040;
RA Dorus S., Vallender E.J., Evans P.D., Anderson J.R., Gilbert S.L.,
RA Mahowald M., Wyckoff G.J., Malcom C.M., Lahn B.T.;
RT "Accelerated evolution of nervous system genes in the origin of Homo
RT sapiens.";
RL Cell 119:1027-1040(2004).
CC -!- FUNCTION: Binds opioids in the presence of acidic lipids; probably
CC involved in cell contact. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC anchor {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. IgLON family.
CC {ECO:0000305}.
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DR EMBL; AY665267; AAV74305.1; -; mRNA.
DR RefSeq; NP_001012438.1; NM_001012436.1.
DR AlphaFoldDB; Q5IS61; -.
DR SMR; Q5IS61; -.
DR STRING; 9598.ENSPTRP00000007679; -.
DR GlyCosmos; Q5IS61; 6 sites, No reported glycans.
DR PaxDb; 9598-ENSPTRP00000007679; -.
DR Ensembl; ENSPTRT00000008316.4; ENSPTRP00000007679.3; ENSPTRG00000004489.5.
DR GeneID; 466855; -.
DR KEGG; ptr:466855; -.
DR CTD; 4978; -.
DR eggNOG; KOG3510; Eukaryota.
DR GeneTree; ENSGT00940000160304; -.
DR HOGENOM; CLU_027228_2_2_1; -.
DR InParanoid; Q5IS61; -.
DR OMA; WRHQSAR; -.
DR OrthoDB; 5394513at2759; -.
DR TreeFam; TF325565; -.
DR Proteomes; UP000002277; Chromosome 11.
DR Bgee; ENSPTRG00000004489; Expressed in temporal lobe and 11 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR42757; IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED; 1.
DR PANTHER; PTHR42757:SF9; NEUROTRIMIN; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 2: Evidence at transcript level;
KW Cell adhesion; Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor;
KW Immunoglobulin domain; Lipoprotein; Membrane; Reference proteome; Repeat;
KW Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000250"
FT CHAIN 28..322
FT /note="Opioid-binding protein/cell adhesion molecule"
FT /id="PRO_0000015120"
FT PROPEP 323..345
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000015121"
FT DOMAIN 39..126
FT /note="Ig-like C2-type 1"
FT DOMAIN 136..219
FT /note="Ig-like C2-type 2"
FT DOMAIN 223..310
FT /note="Ig-like C2-type 3"
FT LIPID 322
FT /note="GPI-anchor amidated asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 70
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 140
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 285
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 293
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 306
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 57..115
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 157..202
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 244..296
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 345 AA; 38008 MW; E7AD17BEA1AA3FF4 CRC64;
MGVCGYLFLP WKCLVVVSLR LLFLVPTGVP VRSGDATFPK AMDNVTVRQG ESATLRCTID
DRVTRVAWLN RSTILYAGND KWSIDPRVII LVNTPTQYSI MIQNVDVYDE GPYTCSVQTD
NHPKTSRVHL IVQVPPQIMN ISSDITVNEG SSVTLLCLAI GRPEPTVTWR HLSVKEGQGF
VSEDEYLEIS DIKRDQSGEY ECSALNDVAA PDVRKVKITV NYPPYISKAK NTGVSVGQKG
ILSCEASAVP MAEFQWFKEE TRLATGLDGM RIENKGRMST LTFFNVSEKD YGNYTCVATN
KLGNTNASIT LYGPGAVIDG VNSASRALAC LWLSGTLLAH FFIKF
//
