ID OR4P4_HUMAN Reviewed; 312 AA.
AC Q8NGL7;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 24-JAN-2024, entry version 156.
DE RecName: Full=Olfactory receptor 4P4;
DE AltName: Full=Olfactory receptor 4P3;
GN Name=OR4P4; Synonyms=OR4P3P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4P4";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065775; BAC05995.1; -; Genomic_DNA.
DR CCDS; CCDS31504.1; -.
DR RefSeq; NP_001004124.1; NM_001004124.2.
DR AlphaFoldDB; Q8NGL7; -.
DR SMR; Q8NGL7; -.
DR STRING; 9606.ENSP00000493384; -.
DR GlyCosmos; Q8NGL7; 2 sites, No reported glycans.
DR GlyGen; Q8NGL7; 2 sites.
DR BioMuta; OR4P4; -.
DR DMDM; 38372725; -.
DR PaxDb; 9606-ENSP00000324831; -.
DR PeptideAtlas; Q8NGL7; -.
DR ProteomicsDB; 73550; -.
DR Antibodypedia; 58936; 108 antibodies from 23 providers.
DR DNASU; 81300; -.
DR Ensembl; ENST00000641760.1; ENSP00000493384.1; ENSG00000181927.4.
DR GeneID; 81300; -.
DR KEGG; hsa:81300; -.
DR MANE-Select; ENST00000641760.1; ENSP00000493384.1; NM_001405919.1; NP_001392848.1.
DR UCSC; uc010rij.2; human.
DR AGR; HGNC:15180; -.
DR CTD; 81300; -.
DR GeneCards; OR4P4; -.
DR HGNC; HGNC:15180; OR4P4.
DR HPA; ENSG00000181927; Not detected.
DR neXtProt; NX_Q8NGL7; -.
DR OpenTargets; ENSG00000181927; -.
DR PharmGKB; PA32337; -.
DR VEuPathDB; HostDB:ENSG00000181927; -.
DR eggNOG; ENOG502SIGU; Eukaryota.
DR GeneTree; ENSGT00940000162616; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGL7; -.
DR OMA; IMISIMC; -.
DR OrthoDB; 4052270at2759; -.
DR PhylomeDB; Q8NGL7; -.
DR TreeFam; TF337350; -.
DR PathwayCommons; Q8NGL7; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 81300; 11 hits in 697 CRISPR screens.
DR GeneWiki; OR4P4; -.
DR GenomeRNAi; 81300; -.
DR Pharos; Q8NGL7; Tdark.
DR PRO; PR:Q8NGL7; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGL7; Protein.
DR Bgee; ENSG00000181927; Expressed in ventricular zone.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR CDD; cd15939; 7tmA_OR4A-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR48002; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR48002:SF101; OLFACTORY RECEPTOR 4P4; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 4P4"
FT /id="PRO_0000150566"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..287
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 312 AA; 35795 MW; A12C645BB7159731 CRC64;
MEKSNNSTLF ILLGFSQNKN IEVLCFVLFL FCYIAIWMGN LLIMISITCT QLIHQPMYFF
LNYLSLSDLC YTSTVTPKLM VDLLAERKTI SYNNCMIQLF TTHFFGGIEI FILTGMAYDR
YVAICKPLHY TIIMSRQKCN TIIIVCCTGG FIHSASQFLL TIFVPFCGPN EIDHYFCDVY
PLLKLACSNI HMIGLLVIAN SGLIALVTFV VLLLSYVFIL YTIRAYSAER RSKALATCSS
HVIVVVLFFA PALFIYIRPV TTFSEDKVFA LFYTIIAPMF NPLIYTLRNT EMKNAMRKVW
CCQILLKRNQ LF
//
