ID OSGI1_HUMAN Reviewed; 477 AA.
AC Q9UJX0; Q52M33; Q86UQ1; Q96S88; Q9BZ70;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 03-JUL-2019, sequence version 4.
DT 24-JAN-2024, entry version 159.
DE RecName: Full=Oxidative stress-induced growth inhibitor 1 {ECO:0000305};
DE AltName: Full=Bone marrow stromal cell-derived growth inhibitor {ECO:0000303|PubMed:15569677};
DE Short=BMSC-derived growth inhibitor {ECO:0000303|PubMed:15569677};
DE AltName: Full=Ovary, kidney and liver protein 38;
DE Short=huOKL38;
DE AltName: Full=Pregnancy-induced growth inhibitor OKL38 {ECO:0000305|PubMed:15569677};
GN Name=OSGIN1 {ECO:0000312|HGNC:HGNC:30093};
GN Synonyms=BDGI {ECO:0000303|PubMed:15569677},
GN OKL38 {ECO:0000303|PubMed:14570898};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=14570898; DOI=10.1074/jbc.m308668200;
RA Ong C.K., Ng C.Y., Leong C., Ng C.P., Foo K.T., Tan P.H., Huynh H.T.;
RT "Genomic structure of human OKL38 gene and its differential expression in
RT kidney carcinogenesis.";
RL J. Biol. Chem. 279:743-754(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND FUNCTION.
RX PubMed=15569677; DOI=10.1074/jbc.m408708200;
RA Wang T., Xia D., Li N., Wang C., Chen T., Wan T., Chen G., Cao X.;
RT "Bone marrow stromal cell-derived growth inhibitor inhibits growth and
RT migration of breast cancer cells via induction of cell cycle arrest and
RT apoptosis.";
RL J. Biol. Chem. 280:4374-4382(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Leukocyte, and Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 62-477, FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Mammary gland, and Ovary;
RX PubMed=11459809; DOI=10.1210/endo.142.8.8297;
RA Huynh H.T., Ng C.Y., Ong C.K., Lim K.B., Chan T.W.M.;
RT "Cloning and characterization of a novel pregnancy-induced growth inhibitor
RT in mammary gland.";
RL Endocrinology 142:3607-3615(2001).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: Regulates the differentiation and proliferation through the
CC regulation of cell death. {ECO:0000269|PubMed:11459809,
CC ECO:0000269|PubMed:14570898, ECO:0000269|PubMed:15569677}.
CC -!- INTERACTION:
CC Q9UJX0; Q9HBZ2: ARNT2; NbExp=3; IntAct=EBI-9057006, EBI-765971;
CC Q9UJX0; O75815: BCAR3; NbExp=4; IntAct=EBI-9057006, EBI-702336;
CC Q9UJX0; Q8N7W2-2: BEND7; NbExp=3; IntAct=EBI-9057006, EBI-10181188;
CC Q9UJX0; Q9BX70: BTBD2; NbExp=3; IntAct=EBI-9057006, EBI-710091;
CC Q9UJX0; P20807: CAPN3; NbExp=4; IntAct=EBI-9057006, EBI-5655000;
CC Q9UJX0; Q96H22-3: CENPN; NbExp=3; IntAct=EBI-9057006, EBI-19948078;
CC Q9UJX0; O43186: CRX; NbExp=3; IntAct=EBI-9057006, EBI-748171;
CC Q9UJX0; Q9NUI1: DECR2; NbExp=3; IntAct=EBI-9057006, EBI-3937367;
CC Q9UJX0; Q96EY1-2: DNAJA3; NbExp=3; IntAct=EBI-9057006, EBI-3952284;
CC Q9UJX0; P48507: GCLM; NbExp=3; IntAct=EBI-9057006, EBI-1051387;
CC Q9UJX0; Q9Y6K9: IKBKG; NbExp=3; IntAct=EBI-9057006, EBI-81279;
CC Q9UJX0; Q9UKT9: IKZF3; NbExp=5; IntAct=EBI-9057006, EBI-747204;
CC Q9UJX0; Q0VD86: INCA1; NbExp=6; IntAct=EBI-9057006, EBI-6509505;
CC Q9UJX0; Q9H079: KATNBL1; NbExp=3; IntAct=EBI-9057006, EBI-715394;
CC Q9UJX0; O95678: KRT75; NbExp=3; IntAct=EBI-9057006, EBI-2949715;
CC Q9UJX0; Q8TBB1: LNX1; NbExp=6; IntAct=EBI-9057006, EBI-739832;
CC Q9UJX0; A8MW99: MEI4; NbExp=3; IntAct=EBI-9057006, EBI-19944212;
CC Q9UJX0; O14770: MEIS2; NbExp=4; IntAct=EBI-9057006, EBI-2804934;
CC Q9UJX0; P50221: MEOX1; NbExp=3; IntAct=EBI-9057006, EBI-2864512;
CC Q9UJX0; P50222: MEOX2; NbExp=3; IntAct=EBI-9057006, EBI-748397;
CC Q9UJX0; Q7Z6M4: MTERF4; NbExp=5; IntAct=EBI-9057006, EBI-948435;
CC Q9UJX0; Q02548: PAX5; NbExp=3; IntAct=EBI-9057006, EBI-296331;
CC Q9UJX0; P27815-4: PDE4A; NbExp=3; IntAct=EBI-9057006, EBI-12080840;
CC Q9UJX0; Q08493-2: PDE4C; NbExp=3; IntAct=EBI-9057006, EBI-12169289;
CC Q9UJX0; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-9057006, EBI-79165;
CC Q9UJX0; Q8WUT1: POLDIP3; NbExp=3; IntAct=EBI-9057006, EBI-10276663;
CC Q9UJX0; P62487: POLR2G; NbExp=3; IntAct=EBI-9057006, EBI-347928;
CC Q9UJX0; Q04864: REL; NbExp=3; IntAct=EBI-9057006, EBI-307352;
CC Q9UJX0; Q04864-2: REL; NbExp=3; IntAct=EBI-9057006, EBI-10829018;
CC Q9UJX0; Q8IYX7: SAXO1; NbExp=3; IntAct=EBI-9057006, EBI-3957636;
CC Q9UJX0; O60504: SORBS3; NbExp=3; IntAct=EBI-9057006, EBI-741237;
CC Q9UJX0; Q99081: TCF12; NbExp=4; IntAct=EBI-9057006, EBI-722877;
CC Q9UJX0; P15884: TCF4; NbExp=4; IntAct=EBI-9057006, EBI-533224;
CC Q9UJX0; Q08117: TLE5; NbExp=3; IntAct=EBI-9057006, EBI-717810;
CC Q9UJX0; Q08117-2: TLE5; NbExp=3; IntAct=EBI-9057006, EBI-11741437;
CC Q9UJX0; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-9057006, EBI-2130429;
CC Q9UJX0; B2RXF5: ZBTB42; NbExp=3; IntAct=EBI-9057006, EBI-12287587;
CC Q9UJX0; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-9057006, EBI-14104088;
CC Q9UJX0; Q969J2: ZKSCAN4; NbExp=3; IntAct=EBI-9057006, EBI-2818641;
CC -!- TISSUE SPECIFICITY: Ubiquitous. Highest expression in the ovary,
CC testis, kidney, skeletal muscle and liver (PubMed:11459809,
CC PubMed:14570898, PubMed:15569677). Weakly expressed in spleen, heart,
CC kidney, and pancreas (PubMed:15569677). Highly expressed in tumor cells
CC (at protein level) (PubMed:15569677). {ECO:0000269|PubMed:11459809,
CC ECO:0000269|PubMed:14570898, ECO:0000269|PubMed:15569677}.
CC -!- INDUCTION: By pregnancy.
CC -!- MISCELLANEOUS: Loss of OSGIN1 protein disturbs the balance between cell
CC growth, differentiation, and cell death in normal tissue, resulting in
CC uncontrolled growth and formation of tumors.
CC -!- SIMILARITY: Belongs to the OKL38 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF06662.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAF06662.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAK01722.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAP14662.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
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DR EMBL; AF334780; AAK01722.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AY258066; AAP14662.1; ALT_SEQ; mRNA.
DR EMBL; AY258067; AAP14663.1; -; mRNA.
DR EMBL; AY258068; AAP14664.1; -; mRNA.
DR EMBL; AY037158; AAK67637.1; -; mRNA.
DR EMBL; AK290383; BAF83072.1; -; mRNA.
DR EMBL; AC040169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471114; EAW95511.1; -; Genomic_DNA.
DR EMBL; BC093687; AAH93687.2; -; mRNA.
DR EMBL; BC113417; AAI13418.2; -; mRNA.
DR EMBL; BC032476; AAH32476.1; -; mRNA.
DR EMBL; AF191740; AAF06662.1; ALT_SEQ; mRNA.
DR CCDS; CCDS10939.1; -.
DR RefSeq; NP_892026.1; NM_182981.2.
DR AlphaFoldDB; Q9UJX0; -.
DR BioGRID; 118985; 59.
DR IntAct; Q9UJX0; 47.
DR MINT; Q9UJX0; -.
DR STRING; 9606.ENSP00000355374; -.
DR iPTMnet; Q9UJX0; -.
DR PhosphoSitePlus; Q9UJX0; -.
DR BioMuta; OSGIN1; -.
DR DMDM; 334302887; -.
DR CPTAC; CPTAC-1212; -.
DR MassIVE; Q9UJX0; -.
DR MaxQB; Q9UJX0; -.
DR PaxDb; 9606-ENSP00000355374; -.
DR PeptideAtlas; Q9UJX0; -.
DR Pumba; Q9UJX0; -.
DR Antibodypedia; 16990; 157 antibodies from 23 providers.
DR DNASU; 29948; -.
DR Ensembl; ENST00000361711.7; ENSP00000355374.3; ENSG00000140961.14.
DR Ensembl; ENST00000393306.6; ENSP00000376983.1; ENSG00000140961.14.
DR GeneID; 29948; -.
DR KEGG; hsa:29948; -.
DR MANE-Select; ENST00000393306.6; ENSP00000376983.1; NM_182981.3; NP_892026.1.
DR UCSC; uc002fha.4; human.
DR AGR; HGNC:30093; -.
DR CTD; 29948; -.
DR DisGeNET; 29948; -.
DR GeneCards; OSGIN1; -.
DR HGNC; HGNC:30093; OSGIN1.
DR HPA; ENSG00000140961; Tissue enriched (liver).
DR MIM; 607975; gene.
DR neXtProt; NX_Q9UJX0; -.
DR OpenTargets; ENSG00000140961; -.
DR PharmGKB; PA162398489; -.
DR VEuPathDB; HostDB:ENSG00000140961; -.
DR eggNOG; ENOG502QRUQ; Eukaryota.
DR GeneTree; ENSGT00390000006658; -.
DR HOGENOM; CLU_019308_2_0_1; -.
DR InParanoid; Q9UJX0; -.
DR OMA; ASWDIQT; -.
DR OrthoDB; 2896801at2759; -.
DR PhylomeDB; Q9UJX0; -.
DR TreeFam; TF313502; -.
DR PathwayCommons; Q9UJX0; -.
DR SignaLink; Q9UJX0; -.
DR BioGRID-ORCS; 29948; 22 hits in 1150 CRISPR screens.
DR ChiTaRS; OSGIN1; human.
DR GenomeRNAi; 29948; -.
DR Pharos; Q9UJX0; Tbio.
DR PRO; PR:Q9UJX0; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q9UJX0; Protein.
DR Bgee; ENSG00000140961; Expressed in right lobe of liver and 145 other cell types or tissues.
DR ExpressionAtlas; Q9UJX0; baseline and differential.
DR Genevisible; Q9UJX0; HS.
DR GO; GO:0008083; F:growth factor activity; IDA:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
DR GO; GO:0042981; P:regulation of apoptotic process; IMP:UniProtKB.
DR GO; GO:0030334; P:regulation of cell migration; IMP:UniProtKB.
DR GO; GO:0042127; P:regulation of cell population proliferation; IMP:UniProtKB.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR029731; OKL38_fam.
DR PANTHER; PTHR15192:SF15; OXIDATIVE STRESS-INDUCED GROWTH INHIBITOR 1; 1.
DR PANTHER; PTHR15192; PROTEIN CBG05349; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; Growth regulation; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..477
FT /note="Oxidative stress-induced growth inhibitor 1"
FT /id="PRO_0000165371"
FT MOD_RES 12
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT VARIANT 356
FT /note="E -> D (in dbSNP:rs35145453)"
FT /id="VAR_056575"
SQ SEQUENCE 477 AA; 51992 MW; 29E936C20B23E7C0 CRC64;
MSSSRKDHLG ASSSEPLPVI IVGNGPSGIC LSYLLSGYTP YTKPDAIHPH PLLQRKLTEA
PGVSILDQDL DYLSEGLEGR SQSPVALLFD ALLRPDTDFG GNMKSVLTWK HRKEHAIPHV
VLGRNLPGGA WHSIEGSMVI LSQGQWMGLP DLEVKDWMQK KRRGLRNSRA TAGDIAHYYR
DYVVKKGLGH NFVSGAVVTA VEWGTPDPSS CGAQDSSPLF QVSGFLTRNQ AQQPFSLWAR
NVVLATGTFD SPARLGIPGE ALPFIHHELS ALEAATRVGA VTPASDPVLI IGAGLSAADA
VLYARHYNIP VIHAFRRAVD DPGLVFNQLP KMLYPEYHKV HQMMREQSIL SPSPYEGYRS
LPRHQLLCFK EDCQAVFQDL EGVEKVFGVS LVLVLIGSHP DLSFLPGAGA DFAVDPDQPL
SAKRNPIDVD PFTYQSTRQE GLYAMGPLAG DNFVRFVQGG ALAVASSLLR KETRKPP
//
