ID TEGU_SCHMA Reviewed; 190 AA.
AC P14202; Q4TTW6;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 24-JAN-2024, entry version 123.
DE RecName: Full=Tegument antigen {ECO:0000303|PubMed:2429181};
DE AltName: Full=Antigen SmA22.6 {ECO:0000303|PubMed:2429181};
DE AltName: Full=I(H)A {ECO:0000303|PubMed:2429181};
DE AltName: Full=Sm22.6 {ECO:0000303|PubMed:1852171};
DE AltName: Full=Tegumental-allergen-like protein-1 {ECO:0000303|PubMed:22509417};
DE Short=SmTAL1 {ECO:0000303|PubMed:22509417};
DE Short=TAL1 {ECO:0000303|PubMed:22509417};
GN Name=A12 {ECO:0000303|PubMed:1852171};
GN ORFNames=Smp_045200 {ECO:0000303|PubMed:22253936};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Puerto Rican;
RX PubMed=2429181; DOI=10.1016/0166-6851(86)90106-4;
RA Stein L.D., David J.R.;
RT "Cloning of a developmentally regulated tegument antigen of Schistosoma
RT mansoni.";
RL Mol. Biochem. Parasitol. 20:253-264(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1852171; DOI=10.1016/0166-6851(91)90209-o;
RA Jeffs S.A., Hagan P., Allen R., Correa-Oliveira R., Smithers S.R.,
RA Simpson A.J.G.;
RT "Molecular cloning and characterisation of the 22-kilodalton adult
RT Schistosoma mansoni antigen recognised by antibodies from mice protectively
RT vaccinated with isolated tegumental surface membranes.";
RL Mol. Biochem. Parasitol. 46:159-168(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=NMRI;
RX PubMed=16446174; DOI=10.1016/j.imbio.2005.06.004;
RA Pacifico L.G., Fonseca C.T., Chiari L., Oliveira S.C.;
RT "Immunization with Schistosoma mansoni 22.6 kDa antigen induces partial
RT protection against experimental infection in a recombinant protein form but
RT not as DNA vaccine.";
RL Immunobiology 211:97-104(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Puerto Rican;
RA Protasio A.V., Tsai J.I., Babbage A., Nichol S., Hunt M., de Silva N.,
RA Anderson T.J.C., Clark R.C., Davidson C., Dillon G.P., Holroyd N.,
RA LoVerde P.T., Lloyd C., McQuillan J., Oliveira G., Otto T.D.,
RA Parker-Manuel S.J., Quail M.A., Wilson A., Zerlotini A., Dunne D.W.,
RA Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican;
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [6]
RP NOMENCLATURE.
RX PubMed=22509417; DOI=10.1371/journal.pntd.0001593;
RA Fitzsimmons C.M., Jones F.M., Stearn A., Chalmers I.W., Hoffmann K.F.,
RA Wawrzyniak J., Wilson S., Kabatereine N.B., Dunne D.W.;
RT "The Schistosoma mansoni tegumental-allergen-like (TAL) protein family:
RT influence of developmental expression on human IgE responses.";
RL PLoS Negl. Trop. Dis. 6:1593-1593(2012).
CC -!- TISSUE SPECIFICITY: Adult and schistosomula tegument.
CC -!- DEVELOPMENTAL STAGE: This antigen occurs in adults and sporocysts but
CC not in cercariae, eggs or newly transformed schistosomula. It is a
CC developmentally regulated protein.
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DR EMBL; M29837; AAA29856.1; -; mRNA.
DR EMBL; M37003; AAA29922.1; -; mRNA.
DR EMBL; DQ059818; AAY57921.1; -; mRNA.
DR EMBL; HE601631; CCD81561.1; -; Genomic_DNA.
DR PIR; A45601; A45601.
DR PIR; A54518; A54518.
DR RefSeq; XP_018654157.1; XM_018788634.1.
DR AlphaFoldDB; P14202; -.
DR SMR; P14202; -.
DR STRING; 6183.P14202; -.
DR EnsemblMetazoa; Smp_045200.1; Smp_045200.1; Smp_045200.
DR EnsemblMetazoa; Smp_045200.2; Smp_045200.2; Smp_045200.
DR GeneID; 8350544; -.
DR KEGG; smm:Smp_045200; -.
DR WBParaSite; Smp_045200.1; Smp_045200.1; Smp_045200.
DR CTD; 8350544; -.
DR HOGENOM; CLU_1557207_0_0_1; -.
DR InParanoid; P14202; -.
DR OrthoDB; 2995295at2759; -.
DR PhylomeDB; P14202; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR CDD; cd21454; DLC-like_TAL; 1.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.740.10; Protein Inhibitor Of Neuronal Nitric Oxide Synthase; 1.
DR InterPro; IPR037177; DLC_sf.
DR InterPro; IPR001372; Dynein_light_chain_typ-1/2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR Pfam; PF01221; Dynein_light; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM01375; Dynein_light; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF54648; DLC; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 2: Evidence at transcript level;
KW Calcium; Metal-binding; Reference proteome; Repeat.
FT CHAIN 1..190
FT /note="Tegument antigen"
FT /id="PRO_0000073858"
FT DOMAIN 8..43
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 51..77
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 55
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 57
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 59
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 61
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 66
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 190 AA; 22578 MW; F265EFA29AA7ACDB CRC64;
MATETKLSQM EEFIRAFLEI DADSNEMIDK QELIKYCQKY RLDMKLIDPW IARFDTDKDN
KISIEEFCRG FGLKVSEIRR EKDELKKERD GKFPKLPPNI EIIAATMSKT KQYEICCQFK
EYVDNTSRTG NDMREVANKM KSLLDNTYGR VWQVVLLTGS YWMNFSHEPF LSIQFKYNNY
VCLAWRTPSQ
//
