ID APTE_DROME Reviewed; 469 AA.
AC P29673; Q8T9D4; Q9V9H5;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 24-JAN-2024, entry version 201.
DE RecName: Full=Protein apterous;
GN Name=ap; ORFNames=CG8376;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A).
RX PubMed=1349545; DOI=10.1101/gad.6.5.715;
RA Cohen B., McGuffin M.E., Pfeifle C., Segal D., Cohen S.M.;
RT "Apterous, a gene required for imaginal disc development in Drosophila
RT encodes a member of the LIM family of developmental regulatory proteins.";
RL Genes Dev. 6:715-729(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
RX PubMed=1524829; DOI=10.1016/0896-6273(92)90192-g;
RA Bourgouin C., Lundgren S.E., Thomas J.B.;
RT "Apterous is a Drosophila LIM domain gene required for the development of a
RT subset of embryonic muscles.";
RL Neuron 9:549-561(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Head;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the normal development of the wing and halter
CC imaginal disks.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A;
CC IsoId=P29673-1; Sequence=Displayed;
CC Name=B;
CC IsoId=P29673-2; Sequence=VSP_010293;
CC -!- TISSUE SPECIFICITY: Expressed in PNS and CNS.
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DR EMBL; X65158; CAA46276.1; -; Genomic_DNA.
DR EMBL; M92841; AAA28673.1; -; mRNA.
DR EMBL; AE013599; AAF57314.1; -; Genomic_DNA.
DR EMBL; AE013599; AAM68357.2; -; Genomic_DNA.
DR EMBL; AY069815; AAL39960.1; -; mRNA.
DR EMBL; BT005201; AAO61758.1; -; mRNA.
DR PIR; JH0718; JH0718.
DR RefSeq; NP_001163058.1; NM_001169587.2.
DR RefSeq; NP_001163059.1; NM_001169588.2. [P29673-2]
DR RefSeq; NP_523621.2; NM_078897.4. [P29673-2]
DR RefSeq; NP_724428.1; NM_165445.4. [P29673-1]
DR AlphaFoldDB; P29673; -.
DR SMR; P29673; -.
DR BioGRID; 61416; 36.
DR DIP; DIP-23617N; -.
DR IntAct; P29673; 1.
DR STRING; 7227.FBpp0085394; -.
DR PaxDb; 7227-FBpp0085394; -.
DR DNASU; 35509; -.
DR EnsemblMetazoa; FBtr0086058; FBpp0085394; FBgn0267978. [P29673-1]
DR EnsemblMetazoa; FBtr0086059; FBpp0085395; FBgn0267978. [P29673-2]
DR EnsemblMetazoa; FBtr0335274; FBpp0307253; FBgn0267978. [P29673-2]
DR GeneID; 35509; -.
DR KEGG; dme:Dmel_CG8376; -.
DR UCSC; CG8376-RA; d. melanogaster. [P29673-1]
DR AGR; FB:FBgn0267978; -.
DR CTD; 11763; -.
DR FlyBase; FBgn0267978; ap.
DR VEuPathDB; VectorBase:FBgn0267978; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000165771; -.
DR HOGENOM; CLU_027802_2_2_1; -.
DR InParanoid; P29673; -.
DR OMA; VCNTPLN; -.
DR OrthoDB; 932158at2759; -.
DR PhylomeDB; P29673; -.
DR SignaLink; P29673; -.
DR BioGRID-ORCS; 35509; 1 hit in 3 CRISPR screens.
DR GenomeRNAi; 35509; -.
DR PRO; PR:P29673; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0267978; Expressed in wing disc and 48 other cell types or tissues.
DR ExpressionAtlas; P29673; baseline and differential.
DR Genevisible; P29673; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0060033; P:anatomical structure regression; IMP:FlyBase.
DR GO; GO:0007411; P:axon guidance; IMP:FlyBase.
DR GO; GO:0045165; P:cell fate commitment; NAS:FlyBase.
DR GO; GO:0007451; P:dorsal/ventral lineage restriction, imaginal disc; TAS:FlyBase.
DR GO; GO:0007450; P:dorsal/ventral pattern formation, imaginal disc; TAS:FlyBase.
DR GO; GO:0048735; P:haltere morphogenesis; IMP:FlyBase.
DR GO; GO:0036011; P:imaginal disc-derived leg segmentation; IMP:FlyBase.
DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
DR GO; GO:0007526; P:larval somatic muscle development; IMP:FlyBase.
DR GO; GO:0035218; P:leg disc development; IMP:FlyBase.
DR GO; GO:0007479; P:leg disc proximal/distal pattern formation; IMP:FlyBase.
DR GO; GO:0007517; P:muscle organ development; IMP:FlyBase.
DR GO; GO:0007399; P:nervous system development; IMP:FlyBase.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007419; P:ventral cord development; HMP:FlyBase.
DR GO; GO:0048190; P:wing disc dorsal/ventral pattern formation; IMP:FlyBase.
DR CDD; cd00086; homeodomain; 1.
DR CDD; cd09369; LIM1_Lhx2_Lhx9; 1.
DR CDD; cd09377; LIM2_Lhx2_Lhx9; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24208; LIM/HOMEOBOX PROTEIN LHX; 1.
DR PANTHER; PTHR24208:SF168; PROTEIN APTEROUS; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; DNA-binding; Homeobox;
KW LIM domain; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc.
FT CHAIN 1..469
FT /note="Protein apterous"
FT /id="PRO_0000075704"
FT DOMAIN 148..200
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 210..263
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DNA_BIND 367..426
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 21..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..223
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_010293"
FT CONFLICT 14
FT /note="Missing (in Ref. 5; AAL39960)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 469 AA; 52053 MW; FA9B43B8C7B9B22D CRC64;
MGVCTEERPV MHWQQSARFL GPGAREKSPT PPVAHQGSNQ CGSAAGANNN HPLFRACSSS
SCPDICDHST KPFGNAYGTE SFRSYETADR ATFEDSAAKF SISRSRTDCT EVSDETTSGI
SFKTEPFGPP SSPESTSDSK ITRNLDDCSG CGRQIQDRFY LSAVEKRWHA SCLQCYACRQ
PLERESSCYS RDGNIYCKND YYSFFGTRRC SRCLASISSN ELVMRARNLV FHVNCFCCTV
CHTPLTKGDQ YGIIDALIYC RTHYSIAREG DTASSSMSAT YPYSAQFGSP HNDSSSPHSD
PSRSIVPTGI FVPASHVING LPQPARQKGR PRKRKPKDIE AFTANIDLNT EYVDFGRGSH
LSSSSRTKRM RTSFKHHQLR TMKSYFAINH NPDAKDLKQL SQKTGLPKRV LQVWFQNARA
KWRRMMMKQD GSGLLEKGEG ALDLDSISVH SPTSFILGGP NSTPPLNLD
//
