ID P74137_SYNY3 Unreviewed; 674 AA.
AC P74137;
DT 01-FEB-1997, integrated into UniProtKB/TrEMBL.
DT 01-FEB-1997, sequence version 1.
DT 27-MAR-2024, entry version 161.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=sll1871 {ECO:0000313|EMBL:BAA18223.1};
OS Synechocystis sp. (strain PCC 6803 / Kazusa).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Merismopediaceae;
OC Synechocystis.
OX NCBI_TaxID=1111708 {ECO:0000313|EMBL:BAA18223.1, ECO:0000313|Proteomes:UP000001425};
RN [1] {ECO:0000313|EMBL:BAA18223.1, ECO:0000313|Proteomes:UP000001425}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 6803 / Kazusa {ECO:0000313|Proteomes:UP000001425};
RX PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT genome and assignment of potential protein-coding regions.";
RL DNA Res. 3:109-136(1996).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; BA000022; BAA18223.1; -; Genomic_DNA.
DR PIR; S75662; S75662.
DR AlphaFoldDB; P74137; -.
DR IntAct; P74137; 1.
DR STRING; 1148.gene:10499096; -.
DR PaxDb; 1148-1653308; -.
DR EnsemblBacteria; BAA18223; BAA18223; BAA18223.
DR KEGG; syn:sll1871; -.
DR eggNOG; COG2205; Bacteria.
DR InParanoid; P74137; -.
DR PhylomeDB; P74137; -.
DR Proteomes; UP000001425; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd18773; PDC1_HK_sensor; 1.
DR CDD; cd18774; PDC2_HK_sensor; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.10.8.500; HAMP domain in histidine kinase; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR43047:SF72; OSMOSENSING HISTIDINE PROTEIN KINASE SLN1; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:BAA18223.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001425};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 331..383
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 444..666
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 375..434
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 674 AA; 74935 MW; 1322B0AACAA7D420 CRC64;
MVSIIKSVRR SLLLKFVLSY FCLSSVVVAS IFLVANYRAV KGIESQTFNR LNISNNLKEY
QLEQWMEGQK DTLFLLSDIN SIQANTELLK NTSVSDPQYK IIQKRLIEEL REIDLFLPHI
EAINILNTGG IVVASNNLDE IGVYKGIGNQ TTYFANINSN FKTVPNFYFS KVYNRPSMTF
ATNIKHDITR ERLGYLSIDI NLNAVDDLIR KRTGLGDTGE TFLVGEINNQ VSFIASDENK
KLTANGSKPN FNSLGINSVM AGNSGQGSYV NYAGTPVLGV YQWIEKYNLA LITEISEVEA
LELARRFTRM LVLVGLVSTA LLLIAVYLLS IKITKPILLI TKAAIDISSG DREARAPVLG
EDELGILAKS FNLMTNELRE SNSSLEKKNQ ELELAQKQLA VANSCLEEKV QQRTEELENT
VKALELASSE AEAANATKSI FLANMSHELR TPLNAIIGYS EMLIEEAEDL DSEELVPDLD
KILRSGKSLL ALINDLLDIS KIEAGKMELY LETFNLKELI AGILDTISPL LKNNNNKLEV
EISLESEEVY GDLIKLRQGI LNLLSNASKF TKDGIISFIV EEFKVDEKDW LSFQVKDTGI
GLTEEQMSKL FQPFTQADSS TTRKYGGTGL GLAITRKFCQ MMGGDIYLTS EIGVGSSFTI
KLPKYAQLNS AKND
//
