ID P74846_SALTM Unreviewed; 591 AA.
AC P74846; F1SVF1; Q7DAP6;
DT 01-FEB-1997, integrated into UniProtKB/TrEMBL.
DT 01-FEB-1997, sequence version 1.
DT 27-MAR-2024, entry version 155.
DE RecName: Full=Mono(ADP-ribosyl)transferase SpvB {ECO:0000256|ARBA:ARBA00014142};
DE EC=2.4.2.31 {ECO:0000256|ARBA:ARBA00012031};
DE AltName: Full=NAD(+)--arginine ADP-ribosyltransferase {ECO:0000256|ARBA:ARBA00033021};
DE AltName: Full=Toxin SpvB {ECO:0000256|ARBA:ARBA00033427};
GN Name=spvB {ECO:0000313|EMBL:AOZ60928.1};
GN ORFNames=AVC05_20470 {ECO:0000313|EMBL:ECY5343584.1}, B1P38_23570
GN {ECO:0000313|EMBL:ECU8356494.1}, CE70_23715
GN {ECO:0000313|EMBL:ECE0298118.1}, DMO92_16890
GN {ECO:0000313|EMBL:EBU9273717.1}, DPS76_19090
GN {ECO:0000313|EMBL:EBW5464521.1}, DRM14_22010
GN {ECO:0000313|EMBL:MLP87941.1}, DU071_08760
GN {ECO:0000313|EMBL:EBY1702037.1}, EER35_14590
GN {ECO:0000313|EMBL:EBZ6922187.1}, F3R12_17110
GN {ECO:0000313|EMBL:ECW0641538.1}, GB466_19380
GN {ECO:0000313|EMBL:HAB0972705.1};
OS Salmonella typhimurium.
OG Plasmid pSTV-Mu1 {ECO:0000313|EMBL:AOZ60928.1}, and
OG Plasmid pYT1 {ECO:0000313|EMBL:BAJ15338.1}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90371 {ECO:0000313|EMBL:CAA77649.1};
RN [1] {ECO:0000313|EMBL:CAA77649.1}
RP NUCLEOTIDE SEQUENCE.
RA Gulig P.;
RL Submitted (DEC-1991) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAA77649.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=1322485; DOI=10.1111/j.1365-2958.1992.tb00860.x;
RA Gulig P.A., Caldwell A.L., Chiodo V.A.;
RT "Identification, genetic analysis and DNA sequence of a 7.8-kb virulence
RT region of the Salmonella typhimurium virulence plasmid.";
RL Mol. Microbiol. 6:1395-1411(1992).
RN [3] {ECO:0000313|EMBL:BAJ15338.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=pYT1 {ECO:0000313|EMBL:BAJ15338.1};
RX PubMed=24155970; DOI=10.1371/journal.pone.0077644;
RA Tamamura Y., Tanaka K., Akiba M., Kanno T., Hatama S., Ishihara R.,
RA Uchida I.;
RT "Complete Nucleotide Sequences of Virulence-Resistance Plasmids Carried by
RT Emerging Multidrug-Resistant Salmonella enterica Serovar Typhimurium
RT Isolated from Cattle in Hokkaido, Japan.";
RL PLoS ONE 8:e77644-e77644(2013).
RN [4] {ECO:0000313|EMBL:AOZ60928.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=pSTV-Mu1 {ECO:0000313|EMBL:AOZ60928.1};
RX PubMed=27767038; DOI=10.1038/srep35527;
RA Abraham S., O'Dea M., Trott D.J., Abraham R.J., Hughes D., Pang S.,
RA McKew G., Cheong E.Y., Merlino J., Saputra S., Malik R., Gottlieb T.;
RT "Isolation and plasmid characterization of carbapenemase (IMP-4) producing
RT Salmonella enterica Typhimurium from cats.";
RL Sci. Rep. 6:35527-35527(2016).
RN [5] {ECO:0000313|EMBL:HAB0972705.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Salmonella enterica {ECO:0000313|EMBL:HAB0972705.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [6] {ECO:0000313|EMBL:EBU9273717.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=356083 {ECO:0000313|EMBL:EBY1702037.1}, 422529
RC {ECO:0000313|EMBL:EBW5464521.1}, 425567 {ECO:0000313|EMBL:MLP87941.1},
RC 43916 {ECO:0000313|EMBL:ECY5343584.1}, 488670
RC {ECO:0000313|EMBL:EBU9273717.1}, and 632340
RC {ECO:0000313|EMBL:EBZ6922187.1};
RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:ECE0298118.1, ECO:0000313|Proteomes:UP000338496}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AUSMDU00020735 {ECO:0000313|EMBL:ECW0641538.1}, and
RC VA_WGS-00080 {ECO:0000313|EMBL:ECE0298118.1,
RC ECO:0000313|Proteomes:UP000338496};
RG GenomeTrakr network: Whole genome sequencing for foodborne pathogen traceback;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:ECU8356494.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PNUSAS008736 {ECO:0000313|EMBL:ECU8356494.1};
RG PulseNet: The National Subtyping Network for Foodborne Disease Surveillance;
RA Tarr C.L., Trees E., Katz L.S., Carleton-Romer H.A., Stroika S.,
RA Kucerova Z., Roache K.F., Sabol A.L., Besser J., Gerner-Smidt P.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:HAB0972705.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Salmonella enterica {ECO:0000313|EMBL:HAB0972705.1};
RG NCBI Pathogen Detection Project;
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-
CC ribosyl)-L-arginyl-[protein] + nicotinamide; Xref=Rhea:RHEA:19149,
CC Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:142554; EC=2.4.2.31;
CC Evidence={ECO:0000256|ARBA:ARBA00000858};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the SpvB family.
CC {ECO:0000256|ARBA:ARBA00010847}.
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DR EMBL; KX777254; AOZ60928.1; -; Genomic_DNA.
DR EMBL; AB576781; BAJ15338.1; -; Genomic_DNA.
DR EMBL; Z11557; CAA77649.1; -; Genomic_DNA.
DR EMBL; AAHDPU010000016; EBU9273717.1; -; Genomic_DNA.
DR EMBL; AAHIPE010000024; EBW5464521.1; -; Genomic_DNA.
DR EMBL; AAHNIA010000013; EBY1702037.1; -; Genomic_DNA.
DR EMBL; AAHRYM010000017; EBZ6922187.1; -; Genomic_DNA.
DR EMBL; AAIGQE010000024; ECE0298118.1; -; Genomic_DNA.
DR EMBL; AAKRET010000036; ECU8356494.1; -; Genomic_DNA.
DR EMBL; AAKVET010000014; ECW0641538.1; -; Genomic_DNA.
DR EMBL; AALDNI010000056; ECY5343584.1; -; Genomic_DNA.
DR EMBL; DAAFPQ010000018; HAB0972705.1; -; Genomic_DNA.
DR EMBL; RVDJ01000030; MLP87941.1; -; Genomic_DNA.
DR PIR; S22664; S22664.
DR RefSeq; WP_001676648.1; NZ_WXYU01000026.1.
DR RefSeq; YP_003264392.1; NC_013437.1.
DR RefSeq; YP_003864189.1; NC_014476.2.
DR RefSeq; YP_006955266.1; NC_019108.1.
DR RefSeq; YP_006955406.1; NC_019109.1.
DR RefSeq; YP_006955575.1; NC_019001.1.
DR SMR; P74846; -.
DR KEGG; seni:CY43_24170; -.
DR PATRIC; fig|90371.1185.peg.5033; -.
DR OMA; RAPVNNI; -.
DR Proteomes; UP000338496; Unassembled WGS sequence.
DR Proteomes; UP000839616; Unassembled WGS sequence.
DR Proteomes; UP000839617; Unassembled WGS sequence.
DR Proteomes; UP000839905; Unassembled WGS sequence.
DR Proteomes; UP000839909; Unassembled WGS sequence.
DR Proteomes; UP000839911; Unassembled WGS sequence.
DR Proteomes; UP000839914; Unassembled WGS sequence.
DR Proteomes; UP000839915; Unassembled WGS sequence.
DR Proteomes; UP000885385; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0106274; F:NAD+-protein-arginine ADP-ribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR003540; ADP-ribosyltransferase.
DR InterPro; IPR003284; Sal_SpvB.
DR Pfam; PF03496; ADPrib_exo_Tox; 1.
DR Pfam; PF03534; SpvB; 1.
DR PRINTS; PR01341; SALSPVBPROT.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR PROSITE; PS51996; TR_MART; 1.
PE 3: Inferred from homology;
KW Plasmid {ECO:0000313|EMBL:AOZ60928.1};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Toxin {ECO:0000256|ARBA:ARBA00022656};
KW Transferase {ECO:0000313|EMBL:EBU9273717.1};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 391..555
FT /note="ADP ribosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF03496"
SQ SEQUENCE 591 AA; 65420 MW; A38F33E02915D5F4 CRC64;
MLILNGFSSA TLALITPPFL PKGGKALSQS GPDGLASITL PLPISAERGF APALALHYSS
GGGNGPFGVG WSCATMSIAR RTSHGVPQYN DSDEFLGPDG EVLVQTLSTG DAPNPVTCFA
YGDVSFPQSY TVTRYQPRTE SSFYRLEYWV GNSNGDDFWL LHDSNGILHL LGKTAAARLS
DPQAASHTAQ WLVEESVTPA GEHIYYSYLA ENGDNVDLNG NEAGRDRSAM RYLSKVQYGN
ATPAADLYLW TSATPAVQWL FTLVFDYGER GVDPQVPPAF TAQNSWLARQ DPFSLYNYGF
EIRLHRLCRQ VLMFHHFPDE LGEADTLVSR LLLEYDENPI LTQLCAARTL AYEGDGYRRA
PVNNMMPPPP PPPMMGGNSS RPKSKWAIVE ESKQIQALRY YSAQGYSVIN KYLRGDDYPE
TQAKETLLSR DYLSTNEPSD EEFKNAMSVY INDIAEGLSS LPETDHRVVY RGLKLDKPAL
SDVLKEYTTI GNIIIDKAFM STSPDKAWIN DTILNIYLEK GHKGRILGDV AHFKGEAEML
FPPNTKLKIE SIVNCGSQDF ASQLSKLRLS DDATADTNRI KRIINMRVLN S
//
