ID P79271_PIG Unreviewed; 1128 AA.
AC P79271;
DT 01-MAY-1997, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1997, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=Ryanodine receptor 1 {ECO:0000256|ARBA:ARBA00014291};
DE AltName: Full=Skeletal muscle calcium release channel {ECO:0000256|ARBA:ARBA00032969};
DE AltName: Full=Skeletal muscle ryanodine receptor {ECO:0000256|ARBA:ARBA00031197};
DE AltName: Full=Skeletal muscle-type ryanodine receptor {ECO:0000256|ARBA:ARBA00033030};
DE AltName: Full=Type 1 ryanodine receptor {ECO:0000256|ARBA:ARBA00032832};
DE Flags: Fragment;
GN Name=CRC1 {ECO:0000313|EMBL:CAA89860.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:CAA89860.1};
RN [1] {ECO:0000313|EMBL:CAA89860.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=1312025; DOI=10.1016/0014-5793(92)80076-S;
RA Brenig B., Brem G.;
RT "Genomic organization and analysis of the 5' end of the porcine ryanodine
RT receptor gene (ryr1).";
RL FEBS Lett. 298:277-279(1992).
RN [2] {ECO:0000313|EMBL:CAA89860.1}
RP NUCLEOTIDE SEQUENCE.
RA Schmoelzl S., Leeb T., Brem G., Brenig B.;
RT "Sequence analysis of the 5' regulatory region and partial genomic
RT structure of the porcine skeletal muscle ryanodine receptor (RYR1) gene.";
RL Mol. Biol. 12:1-11(1993).
RN [3] {ECO:0000313|EMBL:CAA89860.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=8930069;
RA Wen G., Leeb T., Reinhart B., Schmoelzl S., Brenig B.;
RT "The porcine skeletal muscle ryanodine receptor gene structure coding
RT region 1 to 10614 harbouring 71 exons.";
RL Anim. Genet. 27:297-304(1996).
RN [4] {ECO:0000313|EMBL:CAA89860.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=8617743; DOI=10.1074/jbc.271.9.4763;
RA Schmoelzl S., Leeb T., Brinkmeier H., Brem G., Brenig B.;
RT "Regulation of tissue-specific expression of the skeletal muscle ryanodine
RT receptor gene.";
RL J. Biol. Chem. 271:4763-4769(1996).
CC -!- SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004326}.
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DR EMBL; Z49778; CAA89860.1; -; Genomic_DNA.
DR AlphaFoldDB; P79271; -.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR Gene3D; 1.10.490.160; -; 1.
DR Gene3D; 2.60.120.920; -; 2.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF10; RYANODINE RECEPTOR 1; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF01365; RYDR_ITPR; 1.
DR Pfam; PF02026; RyR; 2.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 4.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50919; MIR; 4.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000313|EMBL:CAA89860.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-nitrosylation {ECO:0000256|ARBA:ARBA00022799};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}.
FT DOMAIN 98..153
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 160..205
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 211..265
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 271..334
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 582..798
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT NON_TER 1128
FT /evidence="ECO:0000313|EMBL:CAA89860.1"
SQ SEQUENCE 1128 AA; 125948 MW; 92AC3AA896618B09 CRC64;
MGDGGEGEDE VQFLRTDDEV VLQCNATVLK EQLKLCLAAE GFGNRLCFLE PTSNAQNVPP
DLAICCFVLE QSLSVRALQE MLANTVEAGV ESSQGGGHRT LLYGHAILLR HAHSGMYLSC
LTTSRSMTDK LAFDVGLQED ATGEACWWTT HPASKQRSEG EKVRVGDDLI LVSVSSERYL
HLSTASGELQ VDASFMQTLW NMNPICSGCE EGYVTGGHVL RLFHGHMDEC LTISPADSDD
QRRLVYYEGG SVCTHARSLW RLEPLRISWS GSHLRWGQPL RIRHVTTGRY LALIEDQGLV
VVDASKAHTK ATSFCFRISK EKLDTAPKRD VEGMGPPEIK YGESLCFVQH VASGLWLTYA
APDPKALRLG VLKKKAILHQ EGHMDDALSL TRCQQEESQA ARMIYSTAGL YNHFIKGLDS
FSGKPRGSGA PAGTALPLEG VILSLQDLIG YFEPPSEELQ HEEKQSKLRS LRNRQSLFQE
EGMLSLVLNC IDRLNVYTTA AHFAEFAGEE AAESWKEIVN LLYEILASLI RGNRANCALF
SNNLDWLVSK LDRLEASSGI LEVLYCVLIE SPEVLNIIQE NHIKSIISLL DKHGRNHKVL
DVLCSLCVCN GVAVRSNQDL ITENLLPGRE LLLQTNLINY VTSIRPNIFV GRAEGTTQYS
KWYFEVMVDE VVPFLTAQAT HLRVGWALTE GYSPYPGGGE GWGGNGVGDD LYSYGFDGLH
LWTGHVPRLV TSPGQHLLAP EDVVSCCLDL SVPSISFRIN GCPVQGVFEA FNLNGLFFPV
VSFSAGVKVR FLLGGRHGEF KFLPPPGYAP CHEAVLPRER LRLEPIKEYR REGPRGPHLV
GPSRCLSHTD FVPCPVDTVQ IVLPPHLERI REKLAENIHE LWALTRIEQG WTYGPVRDDN
KRLHPCLVDF HSLPEPERNY NLQMSGETLK TLLALGCHVG MADEKAEDNL RKTKLPKTYM
MSNGYKPAPL DLSHVRLTPA QTTLVDRLAE NGHNVWARDR VAQGWSYSAV QDIPARRNPR
LVPYRLLDEA TKRSNRDSLC QAVRTLLGYG YNIEPPDQEP SQVESQSRWD RVRIFRAEKS
YAVQSGRWYF EFEAVTTGEM RVGWARPDLR PDVELGADEL AYVFNGHR
//
