ID   TNNC2_PRODO             Reviewed;          52 AA.
AC   P81074;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   27-MAR-2024, entry version 76.
DE   RecName: Full=Troponin C, skeletal muscle;
DE   Flags: Fragment;
OS   Protopterus dolloi (Slender lungfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Dipnomorpha; Ceratodontiformes; Lepidosirenoidei; Protopteridae;
OC   Protopterus.
OX   NCBI_TaxID=27779;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=9297801; DOI=10.1016/s0305-0491(97)00006-0;
RA   Francois J.M., Altintas A., Gerday C.;
RT   "Characterization of the single tyrosine containing troponin C from
RT   lungfish white muscle. Comparison with several fast skeletal muscle
RT   troponin C's from fish species.";
RL   Comp. Biochem. Physiol. 117B:589-598(1997).
CC   -!- FUNCTION: Troponin is the central regulatory protein of striated muscle
CC       contraction. Tn consists of three components: Tn-I which is the
CC       inhibitor of actomyosin ATPase, Tn-T which contains the binding site
CC       for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the
CC       inhibitory action of Tn on actin filaments.
CC   -!- MISCELLANEOUS: Skeletal muscle troponin C binds four calcium ions.
CC   -!- SIMILARITY: Belongs to the troponin C family. {ECO:0000305}.
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DR   AlphaFoldDB; P81074; -.
DR   SMR; P81074; -.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   PANTHER; PTHR23048; MYOSIN LIGHT CHAIN 1, 3; 1.
DR   PANTHER; PTHR23048:SF46; TROPONIN C2, FAST SKELETAL TYPE; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   SMART; SM00054; EFh; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   1: Evidence at protein level;
KW   Calcium; Direct protein sequencing; Metal-binding; Muscle protein; Repeat.
FT   CHAIN           <1..>52
FT                   /note="Troponin C, skeletal muscle"
FT                   /id="PRO_0000073711"
FT   DOMAIN          2..37
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          38..>52
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         15
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         17
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         19
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         21
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         26
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   NON_TER         1
FT   NON_TER         52
SQ   SEQUENCE   52 AA;  5949 MW;  68E8AE88CA3F79CB CRC64;
     GKSEEELAEF FRIFDKNADG YIDAEELAEI IRSSGEHVTD EEIEELMKDG DK
//