ID P95146_MYCTU Unreviewed; 411 AA.
AC P95146; F2GHS5; I6XZ69; Q7D7V8;
DT 01-MAY-1997, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1997, sequence version 1.
DT 27-MAR-2024, entry version 165.
DE SubName: Full=Probable reductase {ECO:0000313|EMBL:CCP44635.1};
GN OrderedLocusNames=Rv1869c {ECO:0000313|EMBL:CCP44635.1};
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332 {ECO:0000313|EMBL:CCP44635.1, ECO:0000313|Proteomes:UP000001584};
RN [1] {ECO:0000313|EMBL:CCP44635.1, ECO:0000313|Proteomes:UP000001584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv {ECO:0000313|Proteomes:UP000001584};
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
RA Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2] {ECO:0007829|PubMed:21969609}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21969609; DOI=10.1074/mcp.M111.011445;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; AL123456; CCP44635.1; -; Genomic_DNA.
DR RefSeq; NP_216385.1; NC_000962.3.
DR RefSeq; WP_003899055.1; NZ_NVQJ01000013.1.
DR AlphaFoldDB; P95146; -.
DR SMR; P95146; -.
DR STRING; 83332.Rv1869c; -.
DR PaxDb; 83332-Rv1869c; -.
DR DNASU; 885796; -.
DR GeneID; 885796; -.
DR KEGG; mtu:Rv1869c; -.
DR PATRIC; fig|83332.111.peg.2078; -.
DR TubercuList; Rv1869c; -.
DR eggNOG; COG0446; Bacteria.
DR InParanoid; P95146; -.
DR OrthoDB; 4213189at2; -.
DR PhylomeDB; P95146; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IBA:GO_Central.
DR Gene3D; 3.30.390.30; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
DR InterPro; IPR028202; Reductase_C.
DR PANTHER; PTHR43557; APOPTOSIS-INDUCING FACTOR 1; 1.
DR PANTHER; PTHR43557:SF2; RIESKE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR Pfam; PF14759; Reductase_C; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00411; PNDRDTASEI.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
DR SUPFAM; SSF55424; FAD/NAD-linked reductases, dimerisation (C-terminal) domain; 1.
PE 1: Evidence at protein level;
KW Reference proteome {ECO:0000313|Proteomes:UP000001584}.
FT DOMAIN 7..304
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
FT DOMAIN 326..408
FT /note="Reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14759"
SQ SEQUENCE 411 AA; 43629 MW; 26643CA800C8D879 CRC64;
MASSTTFVIV GGGLAGAKAV EALRRSDFGG RIILFGDEEH LPYDRPPLSK EFLAGKKSLS
DFTIQTSDWY RDHDVDVRLG VRVSSLDRSA HTVELPDGAA VRYDKLLLAT GSAPRRPPIP
GSDAAGVHYL RSYNDAVALN SVLVQGSSLA VVGAGWIGLE VAASARQRGV DVTVVETAIQ
PLLAALGEAV GKVFADLHRD QGVDLRLQTQ LEEITAADGK ATGLKMRDGS TVAADAVLVA
VGAKPNVELA QQAGLAMGEG GVLVDASLRT SDPDIYAVGD IAAAEHPLLG TRVRTEHWAN
ALKQPAVAAA GMLGRPGEYA ELPYLFTDQY DLGMEYVGHA PSCDRVVFRG NVAGREFLSF
WLDGDSRVLA GMNVNVWDVV DDVKGLIRSG NPVDVDRLVD PQWPLADLTT N
//
