ID PARA4_ECOLX Reviewed; 219 AA.
AC P22996;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1991, sequence version 1.
DT 28-JUN-2023, entry version 87.
DE RecName: Full=Resolvase;
GN Name=parA;
OS Escherichia coli.
OG Plasmid IncP-alpha RP4.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2172207; DOI=10.1128/jb.172.11.6194-6203.1990;
RA Gerlitz M., Hrabak O., Schwab H.;
RT "Partitioning of broad-host-range plasmid RP4 is a complex system involving
RT site-specific recombination.";
RL J. Bacteriol. 172:6194-6203(1990).
CC -!- FUNCTION: Involved in plasmid partition.
CC -!- SIMILARITY: Belongs to the site-specific recombinase resolvase family.
CC {ECO:0000305}.
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DR EMBL; M59825; AAA26414.1; -; Genomic_DNA.
DR PIR; D37141; D37141.
DR RefSeq; WP_011205802.1; NZ_VMTS01000064.1.
DR AlphaFoldDB; P22996; -.
DR SMR; P22996; -.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000150; F:DNA strand exchange activity; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0030541; P:plasmid partitioning; IEA:UniProtKB-KW.
DR CDD; cd03767; SR_Res_par; 1.
DR Gene3D; 3.40.50.1390; Resolvase, N-terminal catalytic domain; 1.
DR InterPro; IPR006118; Recombinase_CS.
DR InterPro; IPR006119; Resolv_N.
DR InterPro; IPR036162; Resolvase-like_N_sf.
DR InterPro; IPR006120; Resolvase_HTH_dom.
DR PANTHER; PTHR30461; DNA-INVERTASE FROM LAMBDOID PROPHAGE; 1.
DR PANTHER; PTHR30461:SF25; RESOLVASE-RELATED; 1.
DR Pfam; PF02796; HTH_7; 1.
DR Pfam; PF00239; Resolvase; 1.
DR SMART; SM00857; Resolvase; 1.
DR SUPFAM; SSF53041; Resolvase-like; 1.
DR PROSITE; PS00397; RECOMBINASES_1; 1.
DR PROSITE; PS00398; RECOMBINASES_2; 1.
DR PROSITE; PS51736; RECOMBINASES_3; 1.
PE 3: Inferred from homology;
KW DNA integration; DNA recombination; DNA-binding; Plasmid;
KW Plasmid partition.
FT CHAIN 1..219
FT /note="Resolvase"
FT /id="PRO_0000196384"
FT DOMAIN 15..159
FT /note="Resolvase/invertase-type recombinase catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01072"
FT ACT_SITE 23
FT /note="O-(5'-phospho-DNA)-serine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01072"
SQ SEQUENCE 219 AA; 24161 MW; E19BB0C5D4C1E58C CRC64;
MATREQQPEG RRLKVARIYL RASTDEQNLE RQESLVAATR AAGYYVAGIY REKASGARAD
RPELLRMIAD LQPGEVVVAE KIDRISRLPL AEAERLVASI RAKGAKLAVP GVVDLSELAA
EANGVAKIVL ESVQDMLLKL ALQMARDDYE DRRERQRQGV QLAKAAGRYT GRKRDAGMHD
RIITLRSGGS SIAKTAKLVG CSPSQVKRVW AAWNAQQQK
//
