ID PCP_DICDI Reviewed; 406 AA.
AC Q9GPM2; Q54C17;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 24-JAN-2024, entry version 84.
DE RecName: Full=Paracaspase;
DE EC=3.4.22.-;
GN Name=pcp; ORFNames=DDB_G0293196;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11090634; DOI=10.1016/s1097-2765(00)00094-0;
RA Uren A.G., O'Rourke K., Aravind L., Pisabarro M.T., Seshagiri S.,
RA Koonin E.V., Dixit V.M.;
RT "Identification of paracaspases and metacaspases. Two ancient families of
RT caspase-like proteins, one of which plays a key role in MALT lymphoma.";
RL Mol. Cell 6:961-967(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=14681218; DOI=10.1074/jbc.m312741200;
RA Roisin-Bouffay C., Luciani M.-F., Klein G., Levraud J.-P., Adam M.,
RA Golstein P.;
RT "Developmental cell death in dictyostelium does not require paracaspase.";
RL J. Biol. Chem. 279:11489-11494(2004).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=17889831; DOI=10.1016/j.bbrc.2007.09.011;
RA Lam D., Levraud J.-P., Luciani M.-F., Golstein P.;
RT "Autophagic or necrotic cell death in the absence of caspase and bcl-2
RT family members.";
RL Biochem. Biophys. Res. Commun. 363:536-541(2007).
CC -!- FUNCTION: Not required for DIF-induced autophagic cell death and
CC necrotic cell death. {ECO:0000269|PubMed:14681218,
CC ECO:0000269|PubMed:17889831}.
CC -!- DISRUPTION PHENOTYPE: No change in morphology and persistence of
CC induced-cell death. {ECO:0000269|PubMed:14681218,
CC ECO:0000269|PubMed:17889831}.
CC -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
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DR EMBL; AF316600; AAG38592.1; -; mRNA.
DR EMBL; AAFI02000200; EAL60797.1; -; Genomic_DNA.
DR RefSeq; XP_629249.1; XM_629247.1.
DR AlphaFoldDB; Q9GPM2; -.
DR SMR; Q9GPM2; -.
DR STRING; 44689.Q9GPM2; -.
DR MEROPS; C14.A07; -.
DR PaxDb; 44689-DDB0215375; -.
DR EnsemblProtists; EAL60797; EAL60797; DDB_G0293196.
DR GeneID; 8629131; -.
DR KEGG; ddi:DDB_G0293196; -.
DR dictyBase; DDB_G0293196; pcp.
DR HOGENOM; CLU_678684_0_0_1; -.
DR InParanoid; Q9GPM2; -.
DR PRO; PR:Q9GPM2; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0031164; C:contractile vacuolar membrane; IDA:dictyBase.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0033298; P:contractile vacuole organization; IMP:dictyBase.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0006970; P:response to osmotic stress; IMP:dictyBase.
DR Gene3D; 3.40.50.1460; -; 1.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011600; Pept_C14_caspase.
DR PANTHER; PTHR22576:SF37; MALT1 PARACASPASE HOMOLOG; 1.
DR PANTHER; PTHR22576; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Protease; Reference proteome.
FT CHAIN 1..406
FT /note="Paracaspase"
FT /id="PRO_0000384450"
FT REGION 193..374
FT /note="Caspase-like"
FT /evidence="ECO:0000250"
FT ACT_SITE 266
FT /evidence="ECO:0000250"
FT ACT_SITE 311
FT /evidence="ECO:0000250"
SQ SEQUENCE 406 AA; 46537 MW; E2AE4A25C5D86AD7 CRC64;
MSETFIHSVS ENQIIVNDLE NNNDYDNEDN VFIDSSVYNQ ECFMEILKKL EDGKPIHEVV
RFTSHSSYTH TIVKTIQGLF LYVVLKSVNI YGSYYDFQRY IGPSMMIGTY ACPLYRVQYR
INKNDSTGAI IKYSNNLDEC ETYFNHLCKV FNVLTKRLSL NSICCGVGLS DSFYLMNTKT
IKKSSRTRIS FIIGNSKYSQ HRKLDGVIND VNSFYCALLG CSFHSDNIVW LIDSDLRTFY
DKWYTFLQLV QSFQSYIEVV VYYAGHGRSD NGNLKLIMTD GNPVQLSIIA STLTESIKNS
DSLCLFIVDC CRDGENVLPF HYPIESFDDK KNIAVLFACK YGELSYESLE LNAGIFTRSF
VKTITERKNN NISTICNLTD IAIKRIYKNY SGCSLIGNFD CSLLEF
//
