ID PESC_ASPFC Reviewed; 675 AA.
AC B0Y612;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-MAY-2023, entry version 64.
DE RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
DE AltName: Full=Nucleolar protein 7 homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN Name=nop7; ORFNames=AFUB_065290;
OS Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10) (Neosartorya
OS fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=451804;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 144.89 / FGSC A1163 / CEA10;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of erb1, nop7 and
CC ytm1. The complex is held together by erb1, which interacts with nop7
CC via its N-terminal domain and with ytm1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03028}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC Rule:MF_03028}.
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DR EMBL; DS499598; EDP50197.1; -; Genomic_DNA.
DR AlphaFoldDB; B0Y612; -.
DR SMR; B0Y612; -.
DR EnsemblFungi; EDP50197; EDP50197; AFUB_065290.
DR VEuPathDB; FungiDB:AFUB_065290; -.
DR HOGENOM; CLU_019619_1_1_1; -.
DR PhylomeDB; B0Y612; -.
DR Proteomes; UP000001699; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR CDD; cd17709; BRCT_pescadillo_like; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR HAMAP; MF_03028; Pescadillo; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR010613; PES.
DR PANTHER; PTHR12221; PESCADILLO - RELATED; 1.
DR PANTHER; PTHR12221:SF6; PESCADILLO HOMOLOG; 1.
DR Pfam; PF06732; Pescadillo_N; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Ribosome biogenesis; rRNA processing.
FT CHAIN 1..675
FT /note="Pescadillo homolog"
FT /id="PRO_0000370479"
FT DOMAIN 352..471
FT /note="BRCT"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT REGION 309..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 551..675
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT COMPBIAS 501..516
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..577
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 675 AA; 75396 MW; CD8A83F699DA7E91 CRC64;
MGKIKKKGTS GQAKNYITRT QAVRKLQISL PDFRRLCIFK GIYPREPRNK KKASKTSTPN
TTFYYTKDIQ YLLHEPLLRK FREQKAVAKK IARSLGRGEV GDAARLEKNH APKLTLDHVI
KERYPTFIDA LRDLDDALSL LFLFANLPST AHVPPKTIAL CQRLCHEFQH YLITTNSLRK
SFLSIKGIYY QATIQGQDIL WLVPYRFVQR VNGDVDYRIM ATFVDFYTTL LGFVNFRLYS
SIGLRYPPKF DTRSDENGAE LAAFTLEGRG VGDAPKAIEA GNTQATTSTN NKEVSKEIQA
KVDNVIKSAG LDEAKEEPAA ETTEESSETI DKFEPAAPEA DTLPQPDLSG NEAGSLFAPF
TFYISREAPR APLEFILRAF GCKRIGWDAV LGDGAFTHDE TDTRITHQIV DRPQLPESSL
PAIPAASKDG SDAVQKVKPG TRIPGRTYVQ PQWVWDCINE GRLVRPDLYA PGATLPPHLS
PWVKPSRGGY DPKASLAEQE EEGEAELDED SDEEMEEATS DKKAEAKADV GSESEDEDES
VDGGMDVAGT DDDESESEDE EEDFDGFEEE AASESEDEEE AARTQHQKEL EAEAAGLPFS
SNGATSDGSK KKASQAKKIA AKKRKEEEEL ERQKMMMSRK KRKLLEKMIY SNKKQSEEAA
KLRSKRRKLE KGAAK
//
