ID PHOL_MYCBO Reviewed; 352 AA.
AC P0A5S1; A0A1R3Y110; O05830; X2BK92;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=PhoH-like protein;
GN OrderedLocusNames=BQ2027_MB2389C;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PhoH family. {ECO:0000305}.
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DR EMBL; LT708304; SIU01001.1; -; Genomic_DNA.
DR RefSeq; NP_856038.1; NC_002945.3.
DR RefSeq; WP_003412235.1; NC_002945.4.
DR AlphaFoldDB; P0A5S1; -.
DR SMR; P0A5S1; -.
DR GeneID; 45426355; -.
DR PATRIC; fig|233413.5.peg.2624; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003714; PhoH.
DR PANTHER; PTHR30473:SF1; PHOH-LIKE PROTEIN; 1.
DR PANTHER; PTHR30473; PROTEIN PHOH; 1.
DR Pfam; PF02562; PhoH; 1.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; Nucleotide-binding; Reference proteome.
FT CHAIN 1..352
FT /note="PhoH-like protein"
FT /id="PRO_0000201159"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 150..157
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 352 AA; 37799 MW; D34FF896A7678298 CRC64;
MTSRETRAAD AAGARQADAQ VRSSIDVPPD LVVGLLGSAD ENLRALERTL SADLHVRGNA
VTLCGEPADV ALAERVISEL IAIVASGQSL TPEVVRHSVA MLVGTGNESP AEVLTLDILS
RRGKTIRPKT LNQKRYVDAI DANTIVFGIG PAGTGKTYLA MAKAVHALQT KQVTRIILTR
PAVEAGERLG FLPGTLSEKI DPYLRPLYDA LYDMMDPELI PKLMSAGVIE VAPLAYMRGR
TLNDAFIVLD EAQNTTAEQM KMFLTRLGFG SKVVVTGDVT QIDLPGGARS GLRAAVDILE
DIDDIHIAEL TSVDVVRHRL VSEIVDAYAR YEEPGSGLNR AARRASGARG RR
//
