ID PHOU_CLOAB Reviewed; 219 AA.
AC Q97ID9;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=Phosphate-specific transport system accessory protein PhoU homolog {ECO:0000250|UniProtKB:P0A9K7};
DE Short=Pst system accessory protein PhoU homolog {ECO:0000250|UniProtKB:P0A9K7};
DE AltName: Full=Phosphate uptake regulator {ECO:0000312|EMBL:AAK79675.1};
GN Name=phoU {ECO:0000312|EMBL:AAK79675.1}; OrderedLocusNames=CA_C1709;
OS Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS / VKM B-1787).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=272562;
RN [1] {ECO:0000312|EMBL:AAK79675.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX PubMed=11466286; DOI=10.1128/jb.183.16.4823-4838.2001;
RA Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA Smith D.R.;
RT "Genome sequence and comparative analysis of the solvent-producing
RT bacterium Clostridium acetobutylicum.";
RL J. Bacteriol. 183:4823-4838(2001).
RN [2] {ECO:0000305}
RP OPERON STRUCTURE, AND INDUCTION.
RC STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787
RC {ECO:0000269|PubMed:16855236};
RX PubMed=16855236; DOI=10.1128/jb.00491-06;
RA Fischer R.J., Oehmcke S., Meyer U., Mix M., Schwarz K., Fiedler T.,
RA Bahl H.;
RT "Transcription of the pst operon of Clostridium acetobutylicum is dependent
RT on phosphate concentration and pH.";
RL J. Bacteriol. 188:5469-5478(2006).
CC -!- FUNCTION: Plays a role in the regulation of phosphate uptake (By
CC similarity). Encoded together with proteins of the phosphate-specific
CC transport (Pst) system in the polycistronic pstSCAB-phoU operon.
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:O67053}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P0A9K7}.
CC -!- INDUCTION: By phosphate limitation. {ECO:0000269|PubMed:16855236}.
CC -!- SIMILARITY: Belongs to the PhoU family. {ECO:0000255}.
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DR EMBL; AE001437; AAK79675.1; -; Genomic_DNA.
DR PIR; H97110; H97110.
DR RefSeq; NP_348335.1; NC_003030.1.
DR RefSeq; WP_010965016.1; NC_003030.1.
DR AlphaFoldDB; Q97ID9; -.
DR SMR; Q97ID9; -.
DR STRING; 272562.CA_C1709; -.
DR GeneID; 44998204; -.
DR KEGG; cac:CA_C1709; -.
DR PATRIC; fig|272562.8.peg.1911; -.
DR eggNOG; COG0704; Bacteria.
DR HOGENOM; CLU_078518_3_0_9; -.
DR OrthoDB; 9814256at2; -.
DR Proteomes; UP000000814; Chromosome.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0030643; P:intracellular phosphate ion homeostasis; IEA:InterPro.
DR GO; GO:0045936; P:negative regulation of phosphate metabolic process; ISS:UniProtKB.
DR GO; GO:2000186; P:negative regulation of phosphate transmembrane transport; ISS:UniProtKB.
DR GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR GO; GO:0019220; P:regulation of phosphate metabolic process; IGC:UniProtKB.
DR InterPro; IPR028366; P_transport_PhoU.
DR InterPro; IPR038078; PhoU-like_sf.
DR InterPro; IPR026022; PhoU_dom.
DR NCBIfam; TIGR02135; phoU_full; 1.
DR PANTHER; PTHR42930; PHOSPHATE-SPECIFIC TRANSPORT SYSTEM ACCESSORY PROTEIN PHOU; 1.
DR PANTHER; PTHR42930:SF3; PHOSPHATE-SPECIFIC TRANSPORT SYSTEM ACCESSORY PROTEIN PHOU; 1.
DR Pfam; PF01895; PhoU; 2.
DR PIRSF; PIRSF003107; PhoU; 1.
DR SUPFAM; SSF109755; PhoU-like; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Phosphate transport; Reference proteome; Transport.
FT CHAIN 1..219
FT /note="Phosphate-specific transport system accessory
FT protein PhoU homolog"
FT /id="PRO_0000420871"
SQ SEQUENCE 219 AA; 25566 MW; 7CFA92B616758A3F CRC64;
MTRKIFESDL EELHSELLRM GSMAEKQIYD CMEALEKQDE NMAEVIIKKD DIIDDMQKEI
ENKVIRLIAM QQPIVAEDLR NIFTTVKIVT DLERLGDHAV DIAKAIKRLN GEKHHDIVKE
IWNMGNKVKS MIKDSLDAYV ERNLDKAYEV CKRDDDVDSL YKRIFNELLN IMSEDKSKVN
QLTQFLFVCK YLERIGDRTT NVCESTIYLI TGKQVDLND
//
