ID PRP46_YARLI Reviewed; 441 AA.
AC Q6C709;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 24-JAN-2024, entry version 104.
DE RecName: Full=Pre-mRNA-splicing factor PRP46;
DE AltName: Full=Pre-mRNA-processing protein 46;
GN Name=PRP46; OrderedLocusNames=YALI0E04697g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in pre-mRNA splicing and required for cell cycle
CC progression at G2/M. {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat PRL1/PRL2 family. {ECO:0000305}.
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DR EMBL; CR382131; CAG79134.2; -; Genomic_DNA.
DR RefSeq; XP_503553.2; XM_503553.2.
DR AlphaFoldDB; Q6C709; -.
DR SMR; Q6C709; -.
DR STRING; 284591.Q6C709; -.
DR EnsemblFungi; CAG79134; CAG79134; YALI0_E04697g.
DR GeneID; 2912209; -.
DR KEGG; yli:YALI0E04697g; -.
DR VEuPathDB; FungiDB:YALI0_E04697g; -.
DR HOGENOM; CLU_000288_72_2_1; -.
DR InParanoid; Q6C709; -.
DR OMA; FAMCFDQ; -.
DR OrthoDB; 118158at2759; -.
DR Proteomes; UP000001300; Chromosome E.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:EnsemblFungi.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR045241; Prp46/PLRG1-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19923:SF0; PLEIOTROPIC REGULATOR 1; 1.
DR PANTHER; PTHR19923; WD40 REPEAT PROTEINPRL1/PRL2-RELATED; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Repeat; Spliceosome; WD repeat.
FT CHAIN 1..441
FT /note="Pre-mRNA-splicing factor PRP46"
FT /id="PRO_0000051168"
FT REPEAT 130..169
FT /note="WD 1"
FT REPEAT 172..211
FT /note="WD 2"
FT REPEAT 214..253
FT /note="WD 3"
FT REPEAT 256..295
FT /note="WD 4"
FT REPEAT 298..336
FT /note="WD 5"
FT REPEAT 339..379
FT /note="WD 6"
FT REPEAT 388..427
FT /note="WD 7"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 441 AA; 48629 MW; 93EAFF243A1AD778 CRC64;
MPVAKDLFPE YGTLATGENE PSRNIRRAQK LREFQNLELP PYLAKQVAAK MAEKGLAVEA
TGGVAVQRIA GGSQSGQKAL MGASSSALTK HTPSASQPTT HDSLTNLGAN LTQSKPAWHA
PWEIYRVITG HQGWVRSVCV EPENQWFATG SADKTIKIWD LATGKLRLTL TGHIMGVRAL
GVSPRHPYMF SGGEDKMVKC WDLETNKVVR HYHGHLSAVY SLDIHPTLDV LVSAGRDAVA
RVWDIRTRDP VVVLSGHKST INRVKFQASE PQVITASADE TVRLWNLQAG KTMTTLTHHK
KSVRGLTLHP EEFTFSTASA NSSKQWKCPE GDLVLNYDDQ NAIINTLSVN QDNVMFSGGD
NGSIGFYDWK TGHMFQSTQS IPIPGSIESE NGIFDSSFDK TGLRLITCEA DKSIKMWREK
PNATAESDPG LEWKPKIYQT Y
//
