ID Q000X1_CEREL Unreviewed; 116 AA.
AC Q000X1;
DT 14-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 14-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Insulin-like growth factor I {ECO:0000256|ARBA:ARBA00018817};
DE AltName: Full=Somatomedin {ECO:0000256|ARBA:ARBA00030022};
DE Flags: Fragment;
OS Cervus elaphus (Red deer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Cervidae;
OC Cervinae; Cervus.
OX NCBI_TaxID=9860 {ECO:0000313|EMBL:ABJ16445.1};
RN [1] {ECO:0000313|EMBL:ABJ16445.1}
RP NUCLEOTIDE SEQUENCE.
RA Gupta N., Kumar D., Gupta S.C., Malik G., Pandey A., Ahlawat S.P.S.,
RA Sharma U.;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABJ16445.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18092234; DOI=10.1080/08977190701773187;
RA Gu L., Mo E., Yang Z., Zhu X., Fang Z., Sun B., Wang C., Bao J., Sung C.;
RT "Expression and localization of insulin-like growth factor-I in four parts
RT of the red deer antler.";
RL Growth Factors 25:264-279(2007).
CC -!- SUBUNIT: Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a
CC ternary complex with IGFR1 and ITGA6:ITGB4.
CC {ECO:0000256|ARBA:ARBA00011603}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR EMBL; DQ985698; ABJ16445.1; -; mRNA.
DR AlphaFoldDB; Q000X1; -.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd04368; IlGF; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR022341; IGF-I.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR022350; Insulin-like_growth_factor.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR46845; INSULIN-LIKE GROWTH FACTOR I; 1.
DR PANTHER; PTHR46845:SF1; INSULIN-LIKE GROWTH FACTOR I; 1.
DR Pfam; PF00049; Insulin; 2.
DR PRINTS; PR02002; INSLNLIKEGF.
DR PRINTS; PR02005; INSLNLIKEGF1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR622350-50};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..116
FT /note="Insulin-like growth factor I"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004161768"
FT DOMAIN 33..91
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT DISULFID 36..78
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 48..91
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 77..82
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABJ16445.1"
FT NON_TER 116
FT /evidence="ECO:0000313|EMBL:ABJ16445.1"
SQ SEQUENCE 116 AA; 12783 MW; 1D57B673B8449247 CRC64;
LKQVKMPVTS SSHLFYLALC LLAFTSSATA GPETLCGAEL VDALQFVCGD RGFYFNKPTG
YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPTKAA RSVRAQRHTD MPKNPK
//
