ID Q01WE8_SOLUE Unreviewed; 361 AA.
AC Q01WE8;
DT 14-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 14-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=mannonate dehydratase {ECO:0000256|ARBA:ARBA00012927};
DE EC=4.2.1.8 {ECO:0000256|ARBA:ARBA00012927};
GN OrderedLocusNames=Acid_5062 {ECO:0000313|EMBL:ABJ86017.1};
OS Solibacter usitatus (strain Ellin6076).
OC Bacteria; Acidobacteriota; Terriglobia; Bryobacterales; Solibacteraceae;
OC Solibacter.
OX NCBI_TaxID=234267 {ECO:0000313|EMBL:ABJ86017.1};
RN [1] {ECO:0000313|EMBL:ABJ86017.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Ellin6076 {ECO:0000313|EMBL:ABJ86017.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Gilna P.,
RA Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA Janssen P.H., Kuske C.R., Richardson P.;
RT "Complete sequence of Solibacter usitatus Ellin6076.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the dehydration of D-mannonate.
CC {ECO:0000256|ARBA:ARBA00002713}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O;
CC Xref=Rhea:RHEA:20097, ChEBI:CHEBI:15377, ChEBI:CHEBI:17767,
CC ChEBI:CHEBI:57990; EC=4.2.1.8;
CC Evidence={ECO:0000256|ARBA:ARBA00001794};
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC interconversion. {ECO:0000256|ARBA:ARBA00004892}.
CC -!- SIMILARITY: Belongs to the mannonate dehydratase family.
CC {ECO:0000256|ARBA:ARBA00007389}.
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DR EMBL; CP000473; ABJ86017.1; -; Genomic_DNA.
DR AlphaFoldDB; Q01WE8; -.
DR STRING; 234267.Acid_5062; -.
DR KEGG; sus:Acid_5062; -.
DR eggNOG; COG1312; Bacteria.
DR HOGENOM; CLU_058621_0_0_0; -.
DR InParanoid; Q01WE8; -.
DR OrthoDB; 9780250at2; -.
DR UniPathway; UPA00246; -.
DR GO; GO:0008927; F:mannonate dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.150; Divalent-metal-dependent TIM barrel enzymes; 1.
DR InterPro; IPR004628; Man_deHydtase.
DR InterPro; IPR036237; Xyl_isomerase-like_sf.
DR PANTHER; PTHR30387; MANNONATE DEHYDRATASE; 1.
DR PANTHER; PTHR30387:SF2; MANNONATE DEHYDRATASE; 1.
DR Pfam; PF03786; UxuA; 2.
DR PIRSF; PIRSF016049; Man_dehyd; 1.
DR SUPFAM; SSF51658; Xylose isomerase-like; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:ABJ86017.1};
KW Manganese {ECO:0000256|ARBA:ARBA00023211}.
SQ SEQUENCE 361 AA; 40122 MW; C6C24615AB1A950C CRC64;
MTRSAITRSE FGKTILGAIL AARQSRAAVH SNAPGIKLCA QSGATPTDEQ LLFLKQIGAE
YVSVGSTPEL RTAEGFLQIK KRYADAGITV WNIGNTSVHN MPEVTLNLPG RDQKVEEYKQ
YLRNLGKAGI YYTTYAHMGN GIWSSGRSEI RGASAREFDM NSPAKAGVWD GKTWKEPLSH
GRVFTKEEIW DNFTYFIKQV APVAEENSVR IGIHPDDPPV PVLAGVPRCI FSNFEGYKRA
LEIANSPNVG ICLCCGTWLE GGKALTGKDP EEMIRYFGAK KIWKIHFRNV TAPLPHFVET
FMDDGYYDMY KIMKALRDVN YDGIVILDHS PGMVGGNYAQ TAYGYGYMRA LLNRANAEAK
R
//
