ID Q04EK2_OENOB Unreviewed; 688 AA.
AC Q04EK2;
DT 14-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 14-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Cell elongation-specific peptidoglycan D,D-transpeptidase {ECO:0000313|EMBL:ABJ57120.1};
GN OrderedLocusNames=OEOE_1244 {ECO:0000313|EMBL:ABJ57120.1};
OS Oenococcus oeni (strain ATCC BAA-331 / PSU-1).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Oenococcus.
OX NCBI_TaxID=203123 {ECO:0000313|EMBL:ABJ57120.1, ECO:0000313|Proteomes:UP000000774};
RN [1] {ECO:0000313|EMBL:ABJ57120.1, ECO:0000313|Proteomes:UP000000774}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-331 / PSU-1 {ECO:0000313|Proteomes:UP000000774};
RX PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA Makarova K., Slesarev A., Wolf Y., Sorokin A., Mirkin B., Koonin E.,
RA Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA Baldwin K., Lee J.H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J., Hutkins R.,
RA O'Sullivan D., Steele J., Unlu G., Saier M., Klaenhammer T., Richardson P.,
RA Kozyavkin S., Weimer B., Mills D.;
RT "Comparative genomics of the lactic acid bacteria.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; CP000411; ABJ57120.1; -; Genomic_DNA.
DR AlphaFoldDB; Q04EK2; -.
DR STRING; 203123.OEOE_1244; -.
DR KEGG; ooe:OEOE_1244; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_7_0_9; -.
DR Proteomes; UP000000774; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000774};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 72..310
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 350..660
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 73759 MW; 0C08E88EE506389D CRC64;
MIKKPKLENF NKKDSHSDKN NNSPIPVRLN VLLGLSGFLL LLLIIKLGML TIISGKNYST
IVNQTEATVE TTEAPRGVIY DSTGKVLAGN KSIPSISFER LPSITSAEIY KSATRLSKYL
TIDTSALTET QEIDYYLTSS KHSKETIKKL GLSNSAVNKL TSSALYKLEV KYLKKNKLEL
SSSQKNAAAI YNKMAQTTIL STTTLKSTGV TTKEISEIGE RLSQFSGVRI NQGWTRYYPQ
GSSSKTLLGS LSGSSSGLPA SSLSTYLAEG YSRTDSVGIS GIEKEYEQTL RGISKKTQIT
TNSQNKIVSS KVTQSGTAGK NLQLTINSKF QSDVSAALKK YMGTDLTTGG YAAVMNPKTG
GVYAMAGWDR NVKTGKLTQN DLAAIQDPIV MGSAVKPAMV SMALQAGVIT PTSSTQDDQI
IKLAGTAEKH SDFNPTGVKI PLTAEQALED SSNTYMIQLA LKMNGTPYVS GMSLNVSSNI
WQKMRNGFGE FGLGSRTGID LPGETAGYKG SITGSLASSF IDEAFGQYDT YSVIQMARFV
STIANGGYLV QPKVVASVLK SGKNGVRSSV ASEVSPTIQG YVKMNNAQWN VIKTGMWDVA
NGSSQYNTGG TLIHELSPKV AAKTGTAESF VDGQQTQNDT LIMYSPYAPF AIAIAYVGDK
VDSFGAVEKA AAAIYNAFWK DVMPKPND
//
