ID Q05AV9_XENLA Unreviewed; 450 AA.
AC Q05AV9;
DT 14-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 14-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=LOC733436 protein {ECO:0000313|EMBL:AAI23285.1};
DE Flags: Fragment;
GN Name=LOC733436 {ECO:0000313|EMBL:AAI23285.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAI23285.1};
RN [1] {ECO:0000313|EMBL:AAI23285.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary {ECO:0000313|EMBL:AAI23285.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the pseudouridine synthase TruB family.
CC {ECO:0000256|ARBA:ARBA00008999}.
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DR EMBL; BC123284; AAI23285.1; -; mRNA.
DR AlphaFoldDB; Q05AV9; -.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd02572; PseudoU_synth_hDyskerin; 1.
DR CDD; cd21148; PUA_Cbf5; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR Gene3D; 2.30.130.10; PUA domain; 1.
DR InterPro; IPR012960; Dyskerin-like.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR002501; PsdUridine_synth_N.
DR InterPro; IPR002478; PUA.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR036974; PUA_sf.
DR InterPro; IPR004802; tRNA_PsdUridine_synth_B_fam.
DR InterPro; IPR032819; TruB_C.
DR InterPro; IPR004521; Uncharacterised_CHP00451.
DR NCBIfam; TIGR00425; CBF5; 1.
DR NCBIfam; TIGR00451; unchar_dom_2; 1.
DR PANTHER; PTHR23127; CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5; 1.
DR PANTHER; PTHR23127:SF0; H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1; 1.
DR Pfam; PF08068; DKCLD; 1.
DR Pfam; PF01472; PUA; 1.
DR Pfam; PF16198; TruB_C_2; 1.
DR Pfam; PF01509; TruB_N; 1.
DR SMART; SM01136; DKCLD; 1.
DR SMART; SM00359; PUA; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR PROSITE; PS50890; PUA; 1.
PE 2: Evidence at transcript level;
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 45..103
FT /note="Dyskerin-like"
FT /evidence="ECO:0000259|SMART:SM01136"
FT DOMAIN 294..368
FT /note="PUA"
FT /evidence="ECO:0000259|SMART:SM00359"
FT REGION 423..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..450
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 450
FT /evidence="ECO:0000313|EMBL:AAI23285.1"
SQ SEQUENCE 450 AA; 50605 MW; 042C33D04E78DA31 CRC64;
MADVEGSKKK AKKRRSQILG AEDVAAIQHE EDFLIKPESK VAQLDTSQWP LLLKNFDKLN
IRTAHYTPIP SGSNPLKREI SEYIKTGFIN LDKPANPSSH EVVAWIRRIL RSEKTGHSGT
LDPKVTGCLI VCIDRATRLV KSQQSAGKEY VGIVRLHNAL ENELQLSRAL ETLTGALFQR
PPLIAAVKRQ LRVRTIYESK LIEYDPERRL GIFWVSCEAG TYIRTLCVHI GLLLGVGGQM
QELRRVRSGV LGEKDNLVTM HDVLDAQWQF DNNKDESYLR RVIFPLEKLL VSHKRLVMKD
SAVNAICYGA KIMLPGLLRY EDGIELNQEI VVITTKGEAI CIAIALMTTA VISTCDHGIV
AKIKRVIMER DIYPRKWGLG PKASQKKMMI QKGLLDKHGK TNENTPSDWK QGYVDYSATL
KSKQATDAVK RKHTSDTESD SADPSTKKKK
//
