ID Q06JX7_DROTE Unreviewed; 673 AA.
AC Q06JX7;
DT 31-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2006, sequence version 1.
DT 08-NOV-2023, entry version 61.
DE RecName: Full=Cell division control protein {ECO:0000256|PIRNR:PIRNR001767};
GN Name=cdc6 {ECO:0000313|EMBL:ABI31785.1};
OS Drosophila teissieri (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7243 {ECO:0000313|EMBL:ABI31785.1};
RN [1] {ECO:0000313|EMBL:ABI31785.1}
RP NUCLEOTIDE SEQUENCE.
RA Wiggins B.L., Malik H.S.;
RT "Positive selection of Drosophila cdc6, an essential DNA replication-
RT licensing gene, suggests an adaptive choice of replication origins.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the initiation of DNA replication. Also
CC participates in checkpoint controls that ensure DNA replication is
CC completed before mitosis is initiated. {ECO:0000256|PIRNR:PIRNR001767}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR001767}.
CC -!- SIMILARITY: Belongs to the CDC6/cdc18 family.
CC {ECO:0000256|ARBA:ARBA00006184, ECO:0000256|PIRNR:PIRNR001767}.
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DR EMBL; DQ839714; ABI31785.1; -; Genomic_DNA.
DR AlphaFoldDB; Q06JX7; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR CDD; cd00009; AAA; 1.
DR CDD; cd08768; Cdc6_C; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR016314; Cdc6/18.
DR InterPro; IPR015163; Cdc6_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10763:SF26; CELL DIVISION CONTROL PROTEIN 6 HOMOLOG; 1.
DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR Pfam; PF13401; AAA_22; 1.
DR Pfam; PF09079; Cdc6_C; 1.
DR PIRSF; PIRSF001767; Cdc6; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM01074; Cdc6_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Nucleus {ECO:0000256|PIRNR:PIRNR001767}.
FT DOMAIN 300..445
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 575..655
FT /note="Cdc6 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01074"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 67..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 673 AA; 76643 MW; C15ECAE60A6EFBC3 CRC64;
MAAVRRSTRL SSISKTAAAS PLPQSTQTPR RSEVWKRRQP KKVLADSDEE EEEEVEVVTA
IYDLASTVSE NNENRNVLNK MDKIPRRRNS QVQVAQVEPP KTPRSTKKTA GSSRAKRVQE
NREATARFLA SEQDPEEVDP LHGSPPKQRK LHPLPQHLIS PSRLLDRLSI DERQEEEEVE
VPIHKTDKAE QQQKHVAKEQ TKPRPKQQED PLAPKQQEKP PTKQLEKLAT KQQNKTQIKE
QNQSETNEET HQNSQPSPSR NKYQNARRVL NSAETQNLPG RESQLQELRE FFSSHLESQT
SGSLYVSGQP GTGKTACLSL LLRDPEFSKR LQRVYINCTS IASVGAVYKK LCTELQLKVS
GRTERDHLEA IQRHLKTAKR MLLLVLDEID QLCTSRQEVL YTIFEWPALP SSRILLVGIA
NSLDLTDRAL MRLNARCELK PRLMHFPPYS KQQIVEIFKS RLAEAEVLDV FPPVTLQLLA
AKVSAISGDV RRALDIGRRV VEIAEQQKRD GEKEFNMKAL QLEGKDAEEA KEKQDTLKPV
QVTQVAAVLN KVYGASQNLE EDIEASFPLQ QKLMLCTLVL MLRNERNKDI SMGRLHEVYR
RVCAKRNILA LDQTEFTGTV DLVETRGILR IMRKKEPRLH KVLLQWDEKE VHAALSDKQL
IASILSDTAC LSK
//
